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Doripenem Dosage

Applies to the following strengths: 500 mg; 250 mg

Usual Adult Dose for Intraabdominal Infection

500 mg via IV infusion every 8 hours
Duration of therapy: 5 to 14 days

Comments:


Use: As a single agent for the treatment of complicated intraabdominal infections due to Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides caccae, B fragilis, B thetaiotaomicron, B uniformis, B vulgatus, Streptococcus intermedius, S constellatus, and Peptostreptococcus micros

Usual Adult Dose for Pyelonephritis

500 mg via IV infusion every 8 hours
Duration of therapy: 10 days

Comments:


Uses: As a single agent for the treatment of complicated urinary tract infections, including pyelonephritis due to E coli including cases with concurrent bacteremia, K pneumoniae, Proteus mirabilis, P aeruginosa, and Acinetobacter baumannii

Usual Adult Dose for Urinary Tract Infection

500 mg via IV infusion every 8 hours
Duration of therapy: 10 days

Comments:


Uses: As a single agent for the treatment of complicated urinary tract infections, including pyelonephritis due to E coli including cases with concurrent bacteremia, K pneumoniae, Proteus mirabilis, P aeruginosa, and Acinetobacter baumannii

Renal Dose Adjustments

CrCl greater than 50 mL/min: No adjustment recommended.
CrCl 30 to 50 mL/min: 250 mg via IV infusion every 8 hours
CrCl greater than 10 to less than 30 mL/min: 250 mg via IV infusion every 12 hours

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

This drug is hemodialyzable; however, no dose adjustment guidelines have been reported.

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

IV compatibility:

Monitoring:

General:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.