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Dopram Side Effects

Generic Name: doxapram

Note: This document contains side effect information about doxapram. Some of the dosage forms listed on this page may not apply to the brand name Dopram.

For the Consumer

Applies to doxapram: parenteral injection

Side effects include:

Cough, dyspnea, tachypnea, headache, dizziness, apprehension, hypertension, flushing, sweating, nausea, vomiting, diarrhea, urinary retention, muscle spasticity.

For Healthcare Professionals

Applies to doxapram: intravenous solution

General

-In preterm neonates and infants, this drug has caused significant QT interval prolongation (associated with atrioventricular block in some cases), bloody stools, abdominal distension, necrotizing enterocolitis, multiple gastric perforations/increased gastric residuals, neurodevelopmental delay, vomiting, premature teeth eruption, hypertension, irritability, jitteriness, hyperglycemia, glucosuria, erratic limb movements, excessive crying, and disturbed sleep.

-Seizures have occurred in premature neonates with risk factors such as a previous seizure, perinatal asphyxia, or intracerebral hemorrhage. In many cases, this drug was given following administration of xanthine derivatives (e.g., caffeine, aminophylline, or theophylline).[Ref]

Cardiovascular

Frequency not reported: Phlebitis, heart rate variations, lowered T-waves, arrhythmia, ventricular tachycardia, sinus tachycardia, ventricular fibrillation, bradycardia, extrasystole, chest pain, chest tightness, increased blood pressure, flushing[Ref]

Dermatologic

Frequency not reported: Pruritus, sweating[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, diarrhea, defecation desire, salivation[Ref]

Genitourinary

Frequency not reported: Urinary retention, urinary bladder stimulation with spontaneous voiding, elevated BUN, albuminuria[Ref]

Hematologic

Frequency not reported: Hemolysis, decreased hemoglobin, decreased hematocrit, decreased red blood cell count, decreased white blood cell count (in presence of pre-existing leukopenia)[Ref]

Musculoskeletal

Frequency not reported: Muscle spasticity, muscle fasciculation, increased deep tendon reflexes, clonus, bilateral Babinski[Ref]

Nervous system

Frequency not reported: Paresthesia, headache, dizziness, hyperactivity, involuntary movement, convulsion, decreased cerebral blood flow velocity[Ref]

Ocular

Frequency not reported: Pupillary dilation[Ref]

Other

Frequency not reported: Pyrexia, perineal warmth[Ref]

Psychiatric

Frequency not reported: Apprehension, disorientation, hallucination, confusion[Ref]

Respiratory

Frequency not reported: Dyspnea, cough, hyperventilation, tachypnea, laryngospasm, bronchospasm, hiccough, rebound hyperventilation[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Dopram (doxapram)." West-Ward Pharmaceutical Corporation, Eatontown, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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