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Dopram Side Effects

Generic Name: doxapram

Note: This page contains information about the side effects of doxapram. Some of the dosage forms included on this document may not apply to the brand name Dopram.

For the Consumer

Applies to doxapram: parenteral injection

Side effects include:

Cough, dyspnea, tachypnea, headache, dizziness, apprehension, hypertension, flushing, sweating, nausea, vomiting, diarrhea, urinary retention, muscle spasticity.

For Healthcare Professionals

Applies to doxapram: intravenous solution

General

-In preterm neonates and infants, this drug has caused significant QT interval prolongation (associated with atrioventricular block in some cases), bloody stools, abdominal distension, necrotizing enterocolitis, multiple gastric perforations/increased gastric residuals, neurodevelopmental delay, vomiting, premature teeth eruption, hypertension, irritability, jitteriness, hyperglycemia, glucosuria, erratic limb movements, excessive crying, and disturbed sleep.
-Seizures have occurred in premature neonates with risk factors such as a previous seizure, perinatal asphyxia, or intracerebral hemorrhage. In many cases, this drug was given following administration of xanthine derivatives (e.g., caffeine, aminophylline, or theophylline).[Ref]

Cardiovascular

Frequency not reported: Phlebitis, heart rate variations, lowered T-waves, arrhythmia, ventricular tachycardia, sinus tachycardia, ventricular fibrillation, bradycardia, extrasystole, chest pain, chest tightness, increased blood pressure, flushing[Ref]

Dermatologic

Frequency not reported: Pruritus, sweating[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, diarrhea, defecation desire, salivation[Ref]

Genitourinary

Frequency not reported: Urinary retention, urinary bladder stimulation with spontaneous voiding, elevated BUN, albuminuria[Ref]

Hematologic

Frequency not reported: Hemolysis, decreased hemoglobin, decreased hematocrit, decreased red blood cell count, decreased white blood cell count (in presence of pre-existing leukopenia)[Ref]

Musculoskeletal

Frequency not reported: Muscle spasticity, muscle fasciculation, increased deep tendon reflexes, clonus, bilateral Babinski[Ref]

Nervous system

Frequency not reported: Paresthesia, headache, dizziness, hyperactivity, involuntary movement, convulsion, decreased cerebral blood flow velocity[Ref]

Ocular

Frequency not reported: Pupillary dilation[Ref]

Other

Frequency not reported: Pyrexia, perineal warmth[Ref]

Psychiatric

Frequency not reported: Apprehension, disorientation, hallucination, confusion[Ref]

Respiratory

Frequency not reported: Dyspnea, cough, hyperventilation, tachypnea, laryngospasm, bronchospasm, hiccough, rebound hyperventilation[Ref]

References

1. "Product Information. Dopram (doxapram)." West-Ward Pharmaceutical Corporation, Eatontown, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Dopram may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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