Diprolene Side Effects
Generic name: betamethasone topical
Medically reviewed by Drugs.com. Last updated on Jun 5, 2022.
Note: This document contains side effect information about betamethasone topical. Some of the dosage forms listed on this page may not apply to the brand name Diprolene.
For the Consumer
Applies to betamethasone topical: topical application cream, topical application lotion, topical application ointment, topical application spray
Other dosage forms:
- topical application cream, topical application foam, topical application lotion, topical application ointment
Side effects requiring immediate medical attention
Along with its needed effects, betamethasone topical (the active ingredient contained in Diprolene) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking betamethasone topical:
- Burning or stinging
- itching at the application site
- Blistering, burning, crusting, dryness, or flaking of the skin
- cracking or tightening of the skin
- dry skin
- flushing or redness of the skin
- itching, scaling, severe redness, soreness, or swelling of the skin
- thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (eg, between the fingers)
- unusually warm skin
- Blistering, peeling, or loosening of the skin
Incidence not known
- blurred vision
- change in vision
- decreased vision
- eye pain
- loss of vision
- redness and scaling around the mouth
Side effects not requiring immediate medical attention
Some side effects of betamethasone topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Raised, dark red, or wart-like spots on the skin, especially when used on the face
- Burning, itching, and pain in hairy areas, or pus at the root of the hair
Incidence not known
- Acne or pimples
- burning and itching of the skin with pinhead-sized red blisters
- increased hair growth on the forehead, back, arms, and legs
- lightening of normal skin color
- lightening of treated areas of dark skin
- reddish purple lines on the arms, face, legs, trunk, or groin
- softening of the skin
For Healthcare Professionals
Applies to betamethasone topical: topical cream, topical foam, topical gel, topical lotion, topical ointment, topical spray
The most commonly reported side effects were pruritus, burning, itching, irritation.
Rare (less than 0.1%): Hypersensitivity
Common (1% to 10%): Pruritus
Uncommon (0.1% to 1%): Folliculitis, skin infections (including bacterial, fungal and viral skin infections)
Frequency not reported: Dryness, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infections, skin atrophy, striae, miliaria[Ref]
Uncommon (0.1% to 1%): Application site pain
Frequency not reported: Burning, itching, irritation[Ref]
Rare (less than 0.1%): Eye disorder
Frequency not reported: Hyperglycemia
Frequency not reported: Glucosuria
Rare (less than 0.1%): Rebound effect
Frequently asked questions
- Can this cream be used for poison ivy?
- Diprolene: AF vs Augmented vs Regular - What does this mean?
- Is Diprolene available over-the-counter (OTC)?
- How should I apply Diprolene cream?
More about Diprolene (betamethasone topical)
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Reviews (2)
- Patient tips
- Pricing & coupons
- Generic availability
- En español
- Drug class: topical steroids
Related treatment guides
1. Stoppoloni G, Prisco F, Santinelli R, Sicuranza G, Giordano C "Potential hazards of topical steroid therapy." Am J Dis Child 137 (1983): 1130-1
2. Ruiz-Maldonado R, Zapata G, Lourdes T, Robles C "Cushing's syndrome after topical application of corticosteroids." Am J Dis Child 136 (1982): 274-5
3. Reymann F, Kehlet H "Hypothalamic-pituitary-adrenocortical function. Association with topical application of betamethasone dipropionate." Arch Dermatol 115 (1979): 362-3
4. Cunliffe WJ, Burton JL, Holti G, Wright V "Hazards of steroid therapy in hepatic failure." Br J Dermatol 93 (1975): 183-5
5. Walsh P, Aeling JL, Huff L, Weston WL "Hypothalamus-pituitary-adrenal axis suppression by superpotent topical steroids." J Am Acad Dermatol 29 (1993): 501-3
6. Stevens DJ "Cushing's syndrome due to the abuse of betamethasone nasal drops." J Laryngol Otol 102 (1988): 219-21
7. Flynn MD, Beasley P, Tooke JE "Adrenal suppression with intranasal betamethasone drops." J Laryngol Otol 106 (1992): 827-8
8. Salde L, Lassus A "Systemic side-effects of three topical steroids in diseased skin." Curr Med Res Opin 8 (1983): 475-80
9. "Product Information. Diprolene (betamethasone topical)." Schering Corporation (2001):
10. Sneddon I "Perioral dermatitis." Br J Dermatol 87 (1972): 430-4
11. Smith EB, Breneman DL, Griffith RF, Hebert AA, Hickman JG, Maloney JM, Millikan LE, Sulica VI, Dromgoole SH, Sefton J, et al. "Double-blind comparison of naftifine cream and clotrimazole/betamethasone dipropionate cream in the treatment of tinea pedis." J Am Acad Dermatol 26 (1992): 125-7
12. Barkey WF "Striae and persistent tinea corporis related to prolonged use of betamethasone dipropionate 0.05% cream/clotrimazole 1% cream (Lotrisone cream)." J Am Acad Dermatol 17 (1987): 518-9
13. Grice K "Tinea of the hand and forearm. Betamethasone valerate atrophy." Proc R Soc Med 59 (1966): 254-5
14. Hellgren L "Induction of generalized pustular psoriasis by topical use of betamethasone-dipropionate ointment in psoriasis." Ann Clin Res 8 (1976): 317-9
15. Macdonald A "Topical corticosteroid preparations. Hazards and side-effects." Br J Clin Pract 25 (1971): 421-5
16. Ellis CN, Katz HI, Rex IH Jr, Shavin JS, Van Scott EJ, VanderPloeg D "A controlled clinical trial of a new formulation of betamethasone dipropionate cream in once-daily treatment of psoriasis." Clin Ther 11 (1989): 768-74
17. Kitazawa Y "Increased intraocular pressure induced by corticosteroids." Am J Ophthalmol 82 (1976): 492-5
18. Butcher JM, Austin M, McGalliard J, Bourke RD "Bilateral cataracts and glaucoma induced by long term use of steroid eye drops." BMJ 309 (1994): 43
19. Eisenlohr JE "Glaucoma following the prolonged use of topical steroid medication to the eyelids." J Am Acad Dermatol 8 (1983): 878-81
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.