Skip to main content

DHC Plus Side Effects

Generic name: acetaminophen / caffeine / dihydrocodeine

Medically reviewed by Last updated on Jul 22, 2023.

Note: This document contains side effect information about acetaminophen / caffeine / dihydrocodeine. Some dosage forms listed on this page may not apply to the brand name DHC Plus.

Applies to acetaminophen / caffeine / dihydrocodeine: oral capsule, oral tablet.


Oral route (Capsule)

Addiction, Abuse, and Misuse

Acetaminophen/caffeine/dihydrocodeine bitartrate expose patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing acetaminophen/caffeine/dihydrocodeine bitartrate, and monitor all patients regularly for the development of these behaviors or conditions.

Life-Threatening Respiratory Depression

Serious, life-threatening, or fatal respiratory depression may occur with use of acetaminophen / caffeine / dihydrocodeine bitartrate. Monitor for respiratory depression, especially during initiation of acetaminophen / caffeine / dihydrocodeine bitartrate or following a dose increase.

Accidental Ingestion

Accidental ingestion of even one dose of acetaminophen / caffeine / dihydrocodeine bitartrate, especially by children, can result in a fatal overdose of acetaminophen / caffeine / dihydrocodeine bitartrate.

Ultra-Rapid Metabolism of Codeine and Other Risk Factors for Life-Threatening Respiratory Depression in Children

Life-threatening respiratory depression and death have occurred in children who received codeine. Most of the reported cases occurred following tonsillectomy and/or adenoidectomy, and many of the children had evidence of being an ultra-rapid metabolizer of codeine due to a CYP2D6 polymorphism. Acetaminophen / caffeine / dihydrocodeine bitartrate is contraindicated in children younger than 12 years of age and in children younger than 18 years of age following tonsillectomy and/or adenoidectomy. Avoid the use of acetaminophen / caffeine / dihydrocodeine bitartrate in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine.

Neonatal Opioid Withdrawal Syndrome

Prolonged use of acetaminophen / caffeine / dihydrocodeine bitartrate during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid withdrawal syndrome and ensure that appropriate treatment will be available.

Interactions with Drug Affecting Cytochrome P450 Isoenzymes

The effects of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex. Use of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with acetaminophen / caffeine / dihydrocodeine bitartrate requires careful consideration of the effects on the parent drug, codeine, and the active metabolite, morphine.Hepatotoxicity: Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4,000 milligrams per day, and often involve more than one acetaminophen-containing product.

Risks from Concomitant Use with Benzodiazepines or Other CNS Depressants

Concomitant use of opioids with benzodiazepines or other CNS depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of acetaminophen / caffeine / dihydrocodeine bitartrate and benzodiazepines or other CNS depressants for use in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation.

Serious side effects of DHC Plus

Along with its needed effects, acetaminophen / caffeine / dihydrocodeine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / caffeine / dihydrocodeine:

More common


Incidence not known

Other side effects of DHC Plus

Some side effects of acetaminophen / caffeine / dihydrocodeine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to acetaminophen / caffeine / dihydrocodeine: oral capsule, oral tablet.


The most frequently expected adverse reactions based on the individual components may include lightheadedness, dizziness, drowsiness, sedation, nausea, vomiting, constipation, pruritus and skin reactions.[Ref]



Frequency not reported: Hepatotoxicity[Ref]



Frequency not reported: Respiratory depression, cough suppression[Ref]



Frequency not reported: Confusion, physical and psychological dependence, hallucinations vivid dreams


Frequency not reported: Anxiety, anxiety neurosis, excitement, insomnia, irritability, restlessness, tenseness[Ref]



Frequency not reported: Sweating, pruritus, skin reactions


Rare (less than 0.1%): Serious skin reactions such as acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN)


Frequency not reported: Urticaria[Ref]



Frequency not reported: Anaphylactoid reactions, hypersensitivity reactions


Rare (less than 0.1%): Anaphylactoid reactions

Frequency not reported: Hypersensitivity reactions including urticarial or erythematous skin reactions, laryngeal edema, angioedema[Ref]

Nervous system

Postmarketing reports: Serotonin syndrome


Rare (less than 0.1%): Narcosis

Frequency not reported: Lightheadedness, dizziness, drowsiness, sedation, headache


Frequency not reported: Headaches, lightheadedness, tremor[Ref]



Rare (less than 0.1%): Acute renal failure

Frequency not reported: Granulomatous interstitial nephritis


Frequency not reported: Diuresis[Ref]



Frequency not reported: Orthostatic hypotension


Frequency not reported: Extrasystoles, palpitations, tachycardia[Ref]


Postmarketing reports: Adrenal insufficiency


Frequency not reported: Androgen deficiency[Ref]

Chronic opioid use may influence the hypothalamic-pituitary-gonadal axis and lead to androgen deficiency; however, the causal role of opioids is unknown due to the lack of studies into the many medical, physical, lifestyle, and psychological stressors that influence gonadal hormone levels.[Ref]



Frequency not reported: Nausea, vomiting, constipation, abdominal pain, diarrhea, dry mouth, indigestion, spasm of biliary tract


Frequency not reported: Diarrhea, nausea, stomach pain, vomiting[Ref]



Frequency not reported: Urinary retention[Ref]



Frequency not reported: Thrombocytopenia, leukopenia, pancytopenia, neutropenia, thrombocytopenic purpura, agranulocytosis[Ref]



Frequency not reported: Anorexia[Ref]



Frequency not reported: Miosis


Frequency not reported: Scintillating scotoma[Ref]



Frequency not reported: Fatigue


Frequency not reported: Tinnitus[Ref]

More about DHC Plus (acetaminophen / caffeine / dihydrocodeine)

Patient resources

Other brands

Trezix, Dvorah, Panlor, Panlor DC, ... +2 more

Professional resources

Other brands

Trezix, Dvorah

Related treatment guides


1. Product Information. Trezix (acetaminophen / caffeine / dihydrocodeine). WraSer Pharmaceuticals. 2016.

2. Product Information. Acetaminophen/Caffeine/Dihydrocodeine Bitartrate (acetaminophen / caffeine / dihydrocodeine). Xspire Pharma. PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.