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Acetaminophen / Caffeine / Dihydrocodeine Dosage

Medically reviewed by Last updated on Aug 4, 2023.

Applies to the following strengths: 356.4 mg-30 mg-16 mg; 712.8 mg-60 mg-32 mg; 320.5 mg-30 mg-16 mg; 325 mg-30 mg-16 mg

Usual Adult Dose for Pain

Initial dose: 2 capsules orally every 4 hours as needed
Maximum dose: 5 doses or 10 capsules in 24 hours; no more than 2 capsules should be taken within any 4-hour period.


Use: For the management of moderate to moderately severe pain that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Renal Dose Adjustments

Dose adjustment may be required; however, no specific guidelines have been suggested; consider a lower dose in patients with renal impairment

Liver Dose Adjustments

Use with caution; both acetaminophen and dihydrocodeine are metabolized by the liver; acetaminophen, especially at higher doses, may cause hepatotoxicity

Dose Adjustments

Use with caution in elderly patients.

Use with caution in patients with biliary tract disease including pancreatitis.


The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for all opioids intended for outpatient use. The new FDA Opioid Analgesic REMS is a designed to assist in communicating the serious risks of opioid pain medications to patients and health care professionals. It includes a medication guide and elements to assure safe use. For additional information:


Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP450 2D6 polymorphism.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule III


Data not available

Other Comments

Administration advice:

Storage requirements:



Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.