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Deutetrabenazine Side Effects

In Summary

Commonly reported side effects of deutetrabenazine include: drowsiness. Other side effects include: depression, agitation, akathisia, fatigue, and restlessness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to deutetrabenazine: oral tablet

Along with its needed effects, deutetrabenazine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking deutetrabenazine:

More common
  • Body aches or pain
  • chills
  • diarrhea
  • difficulty with breathing
  • difficulty with swallowing
  • discouragement
  • drowsiness
  • dry mouth
  • fear
  • feeling sad or empty
  • fever
  • headache
  • inability to sit still
  • irritability
  • lack of appetite
  • loss of balance control
  • loss of interest or pleasure
  • mask-like face
  • need to keep moving
  • nervousness
  • relaxed and calm feeling
  • restlessness
  • shuffling walk
  • sleepiness or unusual drowsiness
  • slow movement or reflexes
  • slurred speech
  • stiffness of the arms and legs
  • tic-like (jerky) movements of the head, face, mouth, and neck
  • tiredness
  • trembling and shaking of the fingers and hands
  • trouble concentrating
  • trouble sleeping
  • trouble with balance
  • unusual tiredness or weakness
Less common
  • Agitation
  • dizziness
  • problems passing stools

Get emergency help immediately if any of the following symptoms of overdose occur while taking deutetrabenazine:

Symptoms of overdose
  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fixed position of the eye
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • mood or mental changes
  • nausea
  • seeing, hearing, or feeling things that are not there
  • shakiness in the legs, arms, hands, or feet
  • sticking out of the tongue
  • sweating
  • trembling or shaking of the hands or feet
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions
  • vomiting

Some side effects of deutetrabenazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bruising
  • large, flat, blue patches on the skin
Less common

For Healthcare Professionals

Applies to deutetrabenazine: oral tablet


The most common adverse reactions occurring in greater than 8% were somnolence, diarrhea, dry mouth, and fatigue.[Ref]

Nervous system

Very common (10% or more): Sedation/somnolence (11%)
Common (1% to 10%): Dizziness[Ref]


Common (1% to 10%): Contusion[Ref]


Common (1% to 10%): Diarrhea, dry mouth, constipation[Ref]


Common (1% to 10%): Urinary tract infection[Ref]


Common (1% to 10%): Fatigue[Ref]


Common (1% to 10%): Insomnia, anxiety, depression, suicidal ideation, akathisia/agitation/restlessness[Ref]


1. "Product Information. Austedo (deutetrabenazine)." Teva Pharmaceuticals USA, North Wales, PA.

Some side effects of deutetrabenazine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.