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Desirudin Side Effects

For the Consumer

Applies to desirudin: parenteral powder for injection

Side effects include:

Hemorrhage, including hematoma, was most common adverse effect in clinical studies in patients undergoing elective total hip-replacement surgery.

For Healthcare Professionals

Applies to desirudin: subcutaneous powder for injection

General

The most common adverse reaction was hemorrhage.[Ref]

Cardiovascular

Very common (10% or more): Any hemorrhage (30%)

Common (1% to 10%): Serious hemorrhage, deep vein thrombosis

Uncommon (0.1% to 1%): Major hemorrhage

Frequency not reported: Thrombosis, hypotension

Postmarketing reports: Fatal hemorrhage[Ref]

Other

Common (1% to 10%): Wound secretion

Frequency not reported: Leg edema, fever, healing impaired[Ref]

Gastrointestinal

Common (1% to 10%): Nausea

Frequency not reported: Vomiting, hematemesis[Ref]

Hematologic

Common (1% to 10%): Anemia

Frequency not reported: Hemoglobin decreased[Ref]

Dermatologic

Common (1% to 10%): Irritative skin reactions[Ref]

Local

Common (1% to 10%): Injection site mass[Ref]

Immunologic

Frequency not reported: Allergic reaction, anti-hirudin antibodies

Postmarketing reports: Anaphylactic/anaphylactoid reaction[Ref]

Nervous system

Frequency not reported: Dizziness, cerebrovascular disorder[Ref]

Genitourinary

Frequency not reported: Hematuria[Ref]

Musculoskeletal

Frequency not reported: Leg pain[Ref]

Respiratory

Frequency not reported: Epistaxis[Ref]

References

1. "Product Information. Ipravask (desirudin)." Aventis Pharmaceuticals, Swiftwater, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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