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Desirudin Dosage

Applies to the following strength(s): 15 mg

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Deep Vein Thrombosis - Prophylaxis

15 mg subcutaneously every 12 hours with the initial dose given up to 5 to 15 minutes prior to surgery, but after induction of regional block anesthesia (if used).

Up to 12 days administration (9 to 12 days on average) of desirudin has been well tolerated in controlled clinical trials.

Renal Dose Adjustments

Clcr greater than or equal to 31 to 60 mL/min: 5 mg subcutaneously every 12 hours with the initial dose given up to 5 to 15 minutes prior to surgery, but after induction of regional block anesthesia if used. Serum creatinine and aPTT must be monitored at least daily. If aPTT exceeds 2 times control, therapy must be interrupted until the value returns to less than 2 times control, and then therapy should be resumed at a reduced dosage guided by the initial degree of aPTT abnormality.

Clcr less than 31 mL/min: 1.7 mg subcutaneously every 12 hours with the initial dose given up to 5 to 15 minutes prior to surgery, but after induction of regional block anesthesia if used. Serum creatinine and aPTT must be monitored at least daily. If aPTT exceeds 2 times control, therapy must be interrupted until the value returns to less than 2 times control, and then further dose reductions should be guided by the initial degree of aPTT abnormality.

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

Daily aPTT levels have been recommended. Peak aPTT should not rise to greater than two times control. If aPTT exceeds two times control, dose reductions may be necessary or the dose should be held until the aPTT returns to less than two times control.

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