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Cosyntropin Side Effects

For the Consumer

Applies to cosyntropin: injectable powder for injection

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have redness, swelling, or hives where the medicine was injected.

Common side effects may include:

  • fast or slow heartbeats;

  • increased blood pressure; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to cosyntropin: injectable powder for injection, intravenous solution


Cardiovascular side effects have included bradycardia, tachycardia and hypertension.[Ref]


Dermatologic side effects have included rash and slight whealing with splotchy erythema at the injection site.[Ref]


General side effects have included peripheral edema.[Ref]


Hypersensitivity side effects have rarely included anaphylaxis.[Ref]

Patients with a preexisting allergic disease and/or a previous reaction to natural ACTH may experience a rare hypersensitivity reaction to cosyntropin.[Ref]


1. "Product Information. Cortrosyn (cosyntropin)" Organon, West Orange, NJ.

Not all side effects for cosyntropin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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