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Cosyntropin Side Effects

Medically reviewed by Last updated on May 18, 2020.

For the Consumer

Applies to cosyntropin: injection solution reconstituted

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Fast or slow heartbeat.
  • Swelling in the arms or legs.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to cosyntropin: injectable powder for injection, intravenous solution


The following adverse reactions have been reported: anaphylaxis, bradycardia, tachycardia, hypertension, peripheral edema, and rash. With long-term use, side effects related to glucocorticoid and mineralocorticoid effects may occur.[Ref]


Postmarketing reports: Anaphylaxis, hypersensitivity reactions[Ref]

Severe anaphylactic reactions have been reported, including fatalities. Most severe reactions have occurred in patients with a history of asthma or other forms of allergy, although in rare instances, has occurred in patients without a history of allergy. Reactions generally manifest within 30 minutes of administration.[Ref]


Postmarketing reports: Bradycardia, tachycardia, hypertension, peripheral edema[Ref]


Postmarketing reports: Rash[Ref]


Isolated cases of adrenal hemorrhage have been reported.[Ref]

Frequency not reported: Adrenal hemorrhage[Ref]


1. "Product Information. Cosyntropin (cosyntropin)." Sandoz Inc, Broomfield, CO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.