Skip to Content

Cosyntropin Dosage

Applies to the following strength(s): 0.25 mg ; 0.25 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Adrenocortical Insufficiency

Diagnostic test to differentiate primary adrenal from secondary (pituitary) adrenocortical insufficiency:

0.25 to 0.75 mg IM or IV over 2 minutes. If greater cortisol stimulation is needed, 0.25 mg may be administered by IV infusion at 0.04 mg/hour over 6 hours.

Usual Pediatric Dose for Adrenocortical Insufficiency

Diagnostic test to differentiate primary adrenal from secondary (pituitary) adrenocortical insufficiency:

<1 month: 0.015 mg/kg/dose IM or IV
1 month to 2 years: 0.125 mg IM or IV over 2 minutes
>2 years: 0.25 to 0.75 mg IM or IV over 2 minutes. If greater cortisol stimulation is needed, 0.25 mg may be administered by IV infusion at 0.04 mg/hour over 6 hours.

Congenital adrenal hyperplasia evaluation: 1 mg/m2/dose up to a maximum of 1 mg.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Data not available

Precautions

Hypersensitivity reactions including rare anaphylaxis are possible. Therefore, prior to injection, appropriate measures should be in place to treat any possible acute hypersensitivity reaction.

Dialysis

Data not available

Other Comments

Plasma cortisol levels usually peak about 45 to 60 minutes after an injection of cosyntropin. If the 60-minute test period is used, the criterion for a normal response is an approximate doubling of the basal plasma cortisol value.

Hide