Combunox Side Effects

Generic name: ibuprofen / oxycodone

Medically reviewed by Drugs.com. Last updated on Nov 23, 2024.

Note: This document provides detailed information about Combunox Side Effects associated with ibuprofen / oxycodone. Some dosage forms listed on this page may not apply specifically to the brand name Combunox.

Applies to ibuprofen / oxycodone: oral tablet.

Precautions

It is very important that your doctor check your progress while you are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Your doctor will want to check your blood pressure at the beginning of treatment and monitor it throughout treatment with this medicine. If high blood pressure occurs or worsens while taking this medicine, it may lead to serious heart problems.

Do not use more of this medicine or take it more often than your doctor tells you to. This can be life-threatening. Symptoms of an overdose include extreme dizziness or weakness, slow heartbeat or breathing, seizures, trouble breathing, and cold, clammy skin. Call your doctor right away if you notice these symptoms.

Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn babies. Tell your doctor right away if your baby has an abnormal sleep pattern, diarrhea, a high-pitched cry, irritability, shakiness or tremors, weight loss, vomiting, or fails to gain weight.

This medicine may increase your risk of having a heart attack or stroke. This is more likely to occur in people who already have heart disease. People who use this medicine for a long time might also have a higher risk. Some signs of serious heart problems are chest pain, tightness in the chest, fast or irregular heartbeat, or unusual flushing or warmth of the skin. Check with your doctor right away if you notice any of these warning signs.

Ibuprofen and oxycodone combination will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for hay fever, allergies, or colds, sedatives, tranquilizers, sleeping medicine, or other prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Do not drink alcoholic beverages, and check with your medical doctor or dentist before taking any of the medicines listed above, while you are using this medicine.

This medicine may cause bleeding in your stomach or intestines. This is more likely to occur if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, are over 60 years of age, are in poor health, or are using certain other medicines (such as steroids or a blood thinner). These problems can occur at any time with or without warning, and can be fatal. You should contact your doctor immediately if any of the following symptoms occur including black, tarry stools, bloody stools, vomiting of blood or material that looks like coffee grounds, severe or continuing stomach pain, cramping, or burning, trouble breathing, severe or continuing nausea, heartburn and/or indigestion.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause serious allergic reactions, including anaphylaxis, angioedema, or certain skin conditions (Stevens-Johnson syndrome). These reactions can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, blistering, peeling, or loosening of the skin, fever or chills, trouble breathing or swallowing, or any swelling of your hands, face, mouth, or throat while you are using this medicine.

This medicine may cause some people to become drowsy, dizzy, lightheaded, or to feel a false sense of well-being. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert and clearheaded. If these reactions are especially bothersome, check with your doctor.

Dizziness, lightheadedness, or fainting may occur, especially when getting up suddenly from a lying or sitting position. Getting up slowly may lessen this problem.

Before having any kind of surgery (including dental surgery) or emergency treatment, tell the medical doctor or dentist in charge that you are taking this medicine.

Ibuprofen and oxycodone combination may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if dry mouth continues for more than 2 weeks, check with your dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Call your doctor right away if you have confusion, drowsiness, fever, a general feeling of illness, a headache, loss of appetite, nausea, a stiff neck or back, or vomiting. These could be symptoms of a serious condition called aseptic meningitis.

If you have heart disease or congestive heart failure (CHF), tell your doctor if you have unexplained weight gain or edema (fluid retention or body swelling) with this medicine.

Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body.

Using too much of this medicine may cause infertility (unable to have children). Talk with your doctor before using this medicine if you plan to have children.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects of Combunox

Along with its needed effects, ibuprofen / oxycodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ibuprofen / oxycodone:

Get emergency help immediately if any of the following symptoms of overdose occur while taking ibuprofen / oxycodone:

Symptoms of overdose

• change in consciousness
• chest pain or discomfort
• cold and clammy skin
• constricted pupils
• continuing ringing or buzzing or other unexplained noise in the ears
• decreased awareness or responsiveness
• difficult or troubled breathing
• difficulty with sleeping
• disorientation
• drowsiness to profound coma
• fainting
• hearing loss
• irregular, fast or slow, or shallow breathing
• lethargy
• loss of bladder control
• loss of consciousness
• muscle spasm or jerking of all extremities
• pale or blue lips, fingernails, or skin
• seeing, hearing, or feeling things that are not there
• severe sleepiness
• skeletal muscle flaccidity
• sleepiness or unusual drowsiness
• sudden fainting
• sudden loss of consciousness

Other side effects of Combunox

Some side effects of ibuprofen / oxycodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to ibuprofen / oxycodone: oral tablet.

General adverse events

The most commonly reported adverse events have included nausea, vomiting, flatulence, somnolence, and dizziness.^[Ref]

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting, flatulence, constipation, diarrhea, dyspepsia
• Frequency not reported: Abdominal pain, enlarged abdomen, dry mouth, eructation, ileus
• Postmarketing reports:^[Ref]

Abdominal pain, enlarged abdomen, dry mouth, dyspepsia, eructation, and ileus, have been reported in less than 1% of patients.^[Ref]

Cardiovascular

• Common (1% to 10%): Vasodilation, thrombophlebitis
• Frequency not reported: Hypotension, syncope, tachycardia, vasodilation, edema, chest pain^[Ref]

Hypotension, syncope, tachycardia, edema, and chest pain have been reported in less than 1% of patients.^[Ref]

Nervous system

• Very common (10% or more): Dizziness (19.2%), somnolence (17.4%), headache (10.2%)
• Common (1% to 10%): Hyperkinesia, hypertonia
• Frequency not reported: Taste perversion
• Postmarketing reports: Serotonin syndrome^[Ref]

Respiratory

• Frequency not reported: Respiratory depression^[Ref]

Dermatologic

• Common (1% to 10%): Sweat, rash^[Ref]

Metabolic

• Frequency not reported: Hypokalemia^[Ref]

Hypersensitivity

• Postmarketing reports: Anaphylaxis^[Ref]

Hematologic

• Common (1% to 10%): Ecchymosis
• Frequency not reported: Anemia^[Ref]

Psychiatric

• Frequency not reported: Insomnia, euphoria, nervousness, abnormal thinking, anxiety^[Ref]

Insomnia, euphoria, nervousness, abnormal thinking, and anxiety have been reported in less than 1% of patients.^[Ref]

Endocrine

• Postmarketing reports: Adrenal insufficiency, androgen deficiency

Adrenal insufficiency and androgen deficiency have been reported with opioid use, most often with chronic use.

Musculoskeletal

• Frequency not reported: Arthritis, back pain^[Ref]

Genitourinary

• Frequency not reported: Urinary frequency^[Ref]

Other

• Common (1% to 10%): Fever, asthenia
• Frequency not reported: Chills^[Ref]

Ocular

• Frequency not reported: Amblyopia^[Ref]

See also:

Further information

Combunox side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer