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Combunox Side Effects

Generic Name: ibuprofen / oxycodone

Note: This document contains side effect information about ibuprofen / oxycodone. Some of the dosage forms listed on this page may not apply to the brand name Combunox.

For the Consumer

Applies to ibuprofen / oxycodone: oral tablet

Along with its needed effects, ibuprofen / oxycodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ibuprofen / oxycodone:

Less common
  • Feeling faint, dizzy, or lightheaded
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • headache
  • sweating
Rare
  • Abdominal or stomach pain
  • blurred vision
  • changes in skin color
  • chest pain
  • confusion
  • convulsions
  • decrease in frequency of urination
  • decreased urine
  • difficulty in passing urine (dribbling)
  • difficulty with breathing
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up from a lying position
  • dry mouth
  • excessive muscle tone
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • increased need to urinate
  • increased thirst
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • muscle stiffness
  • muscle tension or tightness
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • pain, tenderness, or swelling of the foot or leg
  • painful urination
  • pale skin
  • passing urine more often
  • severe constipation
  • severe vomiting
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking ibuprofen / oxycodone:

Symptoms of overdose
  • Change in consciousness
  • chest pain or discomfort
  • cold and clammy skin
  • constricted pupils
  • continuing ringing or buzzing or other unexplained noise in the ears
  • decreased awareness or responsiveness
  • difficult or troubled breathing
  • difficulty with sleeping
  • disorientation
  • drowsiness to profound coma
  • fainting
  • hearing loss
  • irregular, fast or slow, or shallow breathing
  • lethargy
  • loss of bladder control
  • loss of consciousness
  • muscle spasm or jerking of all extremities
  • pale or blue lips, fingernails, or skin
  • seeing, hearing, or feeling things that are not there
  • severe sleepiness
  • skeletal muscle flaccidity
  • sleepiness or unusual drowsiness
  • sudden fainting
  • sudden loss of consciousness

Some side effects of ibuprofen / oxycodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Acid or sour stomach
  • belching
  • bloated or full feeling
  • diarrhea
  • difficulty having a bowel movement (stool)
  • excess air or gas in the stomach or intestines
  • fever
  • heartburn
  • indigestion
  • lack or loss of strength
  • passing gas
  • stomach discomfort, upset, or pain
Rare
  • Back pain
  • body aches or pain
  • bruising, large, flat, blue or purplish patches in the skin
  • changes in vision
  • chills
  • congestion
  • cough or hoarseness
  • delusions
  • dementia
  • difficult urination
  • difficulty with moving
  • dryness or soreness of the throat
  • enlarged abdomen or stomach
  • false or unusual sense of well-being
  • fear
  • hoarseness
  • impaired vision
  • increase in body movements
  • lower back or side pain
  • nervousness
  • pain, swelling, or redness in the joints
  • rash
  • runny nose
  • swelling
  • taste perversion
  • tender, swollen glands in the neck
  • trouble with sleeping
  • trouble with swallowing
  • voice changes

For Healthcare Professionals

Applies to ibuprofen / oxycodone: oral tablet

General

The most commonly reported adverse events have included nausea, vomiting, flatulence, somnolence, and dizziness.[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, flatulence, constipation, diarrhea, dyspepsia
Frequency not reported: Abdominal pain, enlarged abdomen, dry mouth, eructation, ileus
Postmarketing reports:[Ref]

Abdominal pain, enlarged abdomen, dry mouth, dyspepsia, eructation, and ileus, have been reported in less than 1% of patients.[Ref]

Cardiovascular

Common (1% to 10%): Vasodilation, thrombophlebitis
Frequency not reported: Hypotension, syncope, tachycardia, vasodilation, edema, chest pain[Ref]

Hypotension, syncope, tachycardia, edema, and chest pain have been reported in less than 1% of patients.[Ref]

Nervous system

Very common (10% or more): Dizziness (19.2%), somnolence (17.4%), headache (10.2%)
Common (1% to 10%): Hyperkinesia, hypertonia
Frequency not reported: Taste perversion
Postmarketing reports: Serotonin syndrome[Ref]

Respiratory

Frequency not reported: Respiratory depression[Ref]

Dermatologic

Common (1% to 10%): Sweat, rash[Ref]

Metabolic

Frequency not reported: Hypokalemia[Ref]

Hypersensitivity

Postmarketing reports: Anaphylaxis[Ref]

Hematologic

Common (1% to 10%): Ecchymosis
Frequency not reported: Anemia[Ref]

Psychiatric

Frequency not reported: Insomnia, euphoria, nervousness, abnormal thinking, anxiety[Ref]

Insomnia, euphoria, nervousness, abnormal thinking, and anxiety have been reported in less than 1% of patients.[Ref]

Endocrine

Adrenal insufficiency and androgen deficiency have been reported with opioid use, most often with chronic use.

Postmarketing reports: Adrenal insufficiency, androgen deficiency

Musculoskeletal

Frequency not reported: Arthritis, back pain[Ref]

Genitourinary

Frequency not reported: Urinary frequency[Ref]

Other

Common (1% to 10%): Fever, asthenia
Frequency not reported: Chills[Ref]

Ocular

Frequency not reported: Amblyopia[Ref]

References

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Some side effects of Combunox may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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