Combunox Side Effects
Generic name: ibuprofen / oxycodone
Medically reviewed by Drugs.com. Last updated on Nov 3, 2024.
Note: This document provides detailed information about Combunox Side Effects associated with ibuprofen / oxycodone. Some dosage forms listed on this page may not apply specifically to the brand name Combunox.
Applies to ibuprofen / oxycodone: oral tablet.
Important warnings
This medicine can cause some serious health issues
Serious side effects of Combunox
Along with its needed effects, ibuprofen / oxycodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ibuprofen / oxycodone:
Less common side effects
- feeling faint, dizzy, or lightheaded
- feeling of warmth or heat
- flushing or redness of the skin, especially on the face and neck
- headache
- sweating
Rare side effects
- abdominal or stomach pain
- blurred vision
- changes in skin color
- chest pain
- confusion
- convulsions
- decrease in frequency of urination
- decreased urine
- difficulty in passing urine (dribbling)
- difficulty with breathing
- dizziness
- dizziness, faintness, or lightheadedness when getting up from a lying position
- dry mouth
- excessive muscle tone
- fainting
- fast, pounding, or irregular heartbeat or pulse
- increased need to urinate
- increased thirst
- loss of appetite
- mood changes
- muscle pain or cramps
- muscle stiffness
- muscle tension or tightness
- nausea or vomiting
- numbness or tingling in the hands, feet, or lips
- pain, tenderness, or swelling of the foot or leg
- painful urination
- pale skin
- passing urine more often
- severe constipation
- severe vomiting
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
Get emergency help immediately if any of the following symptoms of overdose occur while taking ibuprofen / oxycodone:
Symptoms of overdose
- change in consciousness
- chest pain or discomfort
- cold and clammy skin
- constricted pupils
- continuing ringing or buzzing or other unexplained noise in the ears
- decreased awareness or responsiveness
- difficult or troubled breathing
- difficulty with sleeping
- disorientation
- drowsiness to profound coma
- fainting
- hearing loss
- irregular, fast or slow, or shallow breathing
- lethargy
- loss of bladder control
- loss of consciousness
- muscle spasm or jerking of all extremities
- pale or blue lips, fingernails, or skin
- seeing, hearing, or feeling things that are not there
- severe sleepiness
- skeletal muscle flaccidity
- sleepiness or unusual drowsiness
- sudden fainting
- sudden loss of consciousness
Other side effects of Combunox
Some side effects of ibuprofen / oxycodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- acid or sour stomach
- belching
- bloated or full feeling
- diarrhea
- difficulty having a bowel movement (stool)
- excess air or gas in the stomach or intestines
- fever
- heartburn
- indigestion
- lack or loss of strength
- passing gas
- stomach discomfort, upset, or pain
Rare side effects
- back pain
- body aches or pain
- bruising, large, flat, blue or purplish patches in the skin
- changes in vision
- chills
- congestion
- cough or hoarseness
- delusions
- dementia
- difficult urination
- difficulty with moving
- dryness or soreness of the throat
- enlarged abdomen or stomach
- false or unusual sense of well-being
- fear
- hoarseness
- impaired vision
- increase in body movements
- lower back or side pain
- nervousness
- pain, swelling, or redness in the joints
- rash
- runny nose
- swelling
- taste perversion
- tender, swollen glands in the neck
- trouble with sleeping
- trouble with swallowing
- voice changes
For healthcare professionals
Applies to ibuprofen / oxycodone: oral tablet.
General adverse events
The most commonly reported adverse events have included nausea, vomiting, flatulence, somnolence, and dizziness.[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea, vomiting, flatulence, constipation, diarrhea, dyspepsia
- Frequency not reported: Abdominal pain, enlarged abdomen, dry mouth, eructation, ileus
- Postmarketing reports:[Ref]
Abdominal pain, enlarged abdomen, dry mouth, dyspepsia, eructation, and ileus, have been reported in less than 1% of patients.[Ref]
Cardiovascular
- Common (1% to 10%): Vasodilation, thrombophlebitis
- Frequency not reported: Hypotension, syncope, tachycardia, vasodilation, edema, chest pain[Ref]
Hypotension, syncope, tachycardia, edema, and chest pain have been reported in less than 1% of patients.[Ref]
Nervous system
- Very common (10% or more): Dizziness (19.2%), somnolence (17.4%), headache (10.2%)
- Common (1% to 10%): Hyperkinesia, hypertonia
- Frequency not reported: Taste perversion
- Postmarketing reports: Serotonin syndrome[Ref]
Respiratory
- Frequency not reported: Respiratory depression[Ref]
Dermatologic
- Common (1% to 10%): Sweat, rash[Ref]
Metabolic
- Frequency not reported: Hypokalemia[Ref]
Hypersensitivity
- Postmarketing reports: Anaphylaxis[Ref]
Hematologic
- Common (1% to 10%): Ecchymosis
- Frequency not reported: Anemia[Ref]
Psychiatric
- Frequency not reported: Insomnia, euphoria, nervousness, abnormal thinking, anxiety[Ref]
Insomnia, euphoria, nervousness, abnormal thinking, and anxiety have been reported in less than 1% of patients.[Ref]
Endocrine
- Postmarketing reports: Adrenal insufficiency, androgen deficiency
Adrenal insufficiency and androgen deficiency have been reported with opioid use, most often with chronic use.
Musculoskeletal
Genitourinary
- Frequency not reported: Urinary frequency[Ref]
Other
- Common (1% to 10%): Fever, asthenia
- Frequency not reported: Chills[Ref]
Ocular
- Frequency not reported: Amblyopia[Ref]
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More about Combunox (ibuprofen / oxycodone)
- Check interactions
- Compare alternatives
- Imprints, shape & color data
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: narcotic analgesic combinations
Patient resources
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Further information
Combunox side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.