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Ibuprofen / oxycodone Pregnancy and Breastfeeding Warnings

Ibuprofen / oxycodone is also known as: Combunox

Ibuprofen / oxycodone Pregnancy Warnings

Ibuprofen-oxycodone is considered contraindicated in the third trimester of pregnancy due to the potential for ibuprofen to cause premature closure of the ductus arteriosus and pulmonary hypertension in the fetus and/or neonate. Ibuprofen-oxycodone is considered contraindicated prior to and during labor and delivery since ibuprofen may inhibit prostaglandin synthetase and thereby possibly prolong labor and inhibit delivery, the oxycodone may possibly cause respiratory depression in the newborn. There have been reports of withdrawal symptoms and/or respiratory depression in neonates whose mothers were taking narcotic analgesics during pregnancy.

Ibuprofen-oxycodone has been assigned to pregnancy category C prior to 30 weeks gestation and category D starting at 30 weeks gestation by the FDA. Animal studies failed to reveal evidence of teratogenicity or developmental toxicity. There are no controlled data in human pregnancy. Ibuprofen-oxycodone is only recommended for use during pregnancy when benefit outweighs risk. Ibuprofen-oxycodone is considered contraindicated during the third trimester of pregnancy (starting at 30 weeks gestation) and immediately prior to or during labor and delivery as premature closure of the ductus arteriosus may occur.

See references

Ibuprofen / oxycodone Breastfeeding Warnings

Ibuprofen has not been detected in human milk. Ibuprofen is considered compatible with breast-feeding by the American Academy of Pediatrics. Oxycodone is excreted into human milk. Adverse effects in the nursing infant from oxycodone therapy have not been reported. However, there is potential for withdrawal symptoms to occur in breast-fed infants when maternal administration of an opioid analgesic, like oxycodone, is discontinued. The manufacturer recommends that due to the potential for serious adverse effects in nursing infants from oxycodone, a decision should be made to discontinue nursing or discontinue ibuprofen-oxycodone, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Combunox (ibuprofen-oxycodone)." Forest Pharmaceuticals, St. Louis, MO.

References for breastfeeding information

  1. "Product Information. Combunox (ibuprofen-oxycodone)." Forest Pharmaceuticals, St. Louis, MO.

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