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Clexane Forte Side Effects

Generic name: enoxaparin

Medically reviewed by Last updated on Jun 10, 2024.

Note: This document contains side effect information about enoxaparin. Some dosage forms listed on this page may not apply to the brand name Clexane Forte.

Applies to enoxaparin: solution.


Injection route (Solution)

Epidural or spinal hematomas, which may result in long-term or permanent paralysis, may occur in patients who are anticoagulated with low molecular weight heparins or heparinoids and are receiving neuraxial anesthesia or undergoing spinal puncture. Factors that can increase the risk of developing these hematomas include: use of indwelling epidural catheters, concomitant use of drugs affecting hemostasis such as NSAIDs, platelet inhibitors, or other anticoagulants, or history of traumatic or repeated epidural or spinal puncture, spinal deformity, or spinal surgery. Optimal timing between the administration of enoxaparin sodium and neuraxial procedures is not known. Monitor patients frequently for neurological impairment. If neurological compromise is noted, urgent treatment is necessary. Consider risks/benefits before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis.

Serious side effects of Clexane Forte

Along with its needed effects, enoxaparin (the active ingredient contained in Clexane Forte) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking enoxaparin:

More common

Less common


Incidence not known

Other side effects of Clexane Forte

Some side effects of enoxaparin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

For Healthcare Professionals

Applies to enoxaparin: injectable solution.


The most common adverse reactions were bleeding, anemia, thrombocytopenia, elevation of serum aminotransferase, diarrhea, and nausea.[Ref]


Common (1% to 10%): Major hemorrhage

Uncommon (0.1% to 1%): Atrial fibrillation, heart failure

Frequency not reported: Hemorrhage

Postmarketing reports: Shock, valve thrombosis in patients with prosthetic heart valves[Ref]


Common (1% to 10%): Thrombocytopenia, anemia, platelet counts between 100,000 and 50,000/mm3

Uncommon (0.1% to 1%): Platelet counts less than 50,000/mm3

Frequency not reported: Thrombocytosis

Postmarketing reports: Hemorrhagic anemia, platelet count increased, eosinophilia[Ref]


Common (1% to 10%): ALT increased asymptomatically, AST increased asymptomatically

Frequency not reported: Hepatic enzymes increased

Postmarketing reports: Hepatocellular liver injury, cholestatic liver injury[Ref]


Common (1% to 10%): Nausea, diarrhea

Uncommon (0.1% to 1%): Retroperitoneal hemorrhage[Ref]


Common (1% to 10%): Injection site hematoma, injection site pain, other injection site reaction

Uncommon (0.1% to 1%): Local irritation, injection site skin necrosis

Postmarketing reports: Injection site nodules[Ref]


Common (1% to 10%): Urticaria, pruritus, erythema

Uncommon (0.1% to 1%): Bullous dermatitis

Postmarketing reports: Cutaneous vasculitis, skin necrosis, alopecia[Ref]


Common (1% to 10%): Peripheral edema, edema

Rare (less than 0.1%): Hyperkalemia

Postmarketing reports: Hyperlipidemia, hypertriglyceridemia[Ref]


Common (1% to 10%): Allergic reaction

Rare (0.01% to 0.1%): Anaphylactic/anaphylactoid reaction

Very rare (less than 0.01%): Immuno-allergic thrombocytopenia

Postmarketing reports: Immuno-allergic thrombocytopenia with thrombosis[Ref]


Common (1% to 10%): Dyspnea

Uncommon (0.1% to 1%): Lung edema, pneumonia[Ref]


Uncommon (0.1% to 1%): Hematuria[Ref]


Common (1% to 10%): Confusion[Ref]


Common (1% to 10%): Fever[Ref]

Nervous system

Uncommon (0.1% to 1%): Intracranial hemorrhage

Postmarketing reports: Headache, spinal hematoma[Ref]


Postmarketing reports: Osteoporosis following treatment longer than 3 months[Ref]


1. (2002) "Product Information. Lovenox (enoxaparin)." Rhone Poulenc Rorer

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.