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Cilostazol Side Effects

Medically reviewed by Last updated on Feb 7, 2022.


Commonly reported side effects of cilostazol include: infection, change in stool, diarrhea, dizziness, headache, palpitations, and pharyngitis. Other side effects include: abdominal pain, peripheral edema, rhinitis, and tachycardia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cilostazol: oral tablets


  • Contraindicated in patients with CHF of any severity.1 2 Decreased survival observed in patients with NYHA class III or IV CHF who received other drugs that inhibit phosphodiesterase (PDE) type 3.1 2

Side effects include:

Headache, diarrhea, abnormal (e.g., loose) stools, dizziness, infection, palpitation, pharyngitis, back pain, nausea, peripheral edema, rhinitis, dyspepsia, increased cough, tachycardia.

For Healthcare Professionals

Applies to cilostazol: oral tablet


The most frequent adverse reactions resulting in discontinuation of therapy were headache, palpitation, and diarrhea.[Ref]

Nervous system

Very common (10% or more): Headache (up to 34%), dizziness (up to 10%)

Frequency not reported: Tinnitus

Postmarketing reports: Intracranial hemorrhage, cerebral hemorrhage, cerebrovascular accident, extradural hematoma, subdural hematoma


Very common (10% or more): Diarrhea (up to 19%), abnormal stools (up to 15%)

Common (1% to 10%): Dyspepsia, abdominal pain

Frequency not reported: Melena

Postmarketing reports: Gastrointestinal hemorrhage, vomiting, flatulence, nausea[Ref]


Very common (10% or more): Infection (up to 14%)

Postmarketing reports: Anaphylaxis, angioedema, hypersensitivity[Ref]


Very common (10% or more): Rhinitis (up to 12%), pharyngitis (up to 10%)

Frequency not reported: Epistaxis

Postmarketing reports: Pulmonary hemorrhage, interstitial pneumonia[Ref]


Very common (10% or more): Palpitation (up to 10%)

Common (1% to 10%): Tachycardia

Frequency not reported: Atrial fibrillation, heart failure, myocardial infarction, nodal arrhythmia, supraventricular tachycardia, ventricular extrasystoles, ventricular tachycardia, left ventricular outflow obstruction

Postmarketing reports: Torsade de pointes, QTc prolongation, angina pectoris, hot flushes, blood pressure increased, subacute stent thrombosis, hypertension[Ref]


Common (1% to 10%): Peripheral edema

Frequency not reported: Fever, generalized edema, malaise

Postmarketing reports: Pain, chest pain[Ref]


Frequency not reported: Anorexia, hyperuricemia

Postmarketing reports: Blood glucose increased, blood uric acid increased[Ref]


Frequency not reported: Conjunctivitis, retinal hemorrhage[Ref]


Frequency not reported: Urticaria

Postmarketing reports: Subcutaneous hemorrhage, pruritus, skin eruptions, Stevens-Johnson syndrome, skin drug eruption, rash[Ref]


Frequency not reported: Anemia

Postmarketing reports: Aplastic anemia, granulocytopenia, pancytopenia, bleeding tendency[Ref]


Frequency not reported: Urinary frequency

Postmarketing reports: Hematuria[Ref]


Frequency not reported: Creatinine increased

Postmarketing reports: BUN increased[Ref]


Frequency not reported: Insomnia[Ref]


Postmarketing reports: Hepatic dysfunction, abnormal liver function tests, jaundice[Ref]


1. "Product Information. Pletal (cilostazol)." Otsuka American Pharmaceuticals Inc (2001):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.