Cilostazol Side Effects
Medically reviewed by Drugs.com. Last updated on Feb 7, 2022.
Summary
Commonly reported side effects of cilostazol include: infection, change in stool, diarrhea, dizziness, headache, palpitations, and pharyngitis. Other side effects include: abdominal pain, peripheral edema, rhinitis, and tachycardia. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to cilostazol: oral tablets
Warning
Side effects include:
Headache, diarrhea, abnormal (e.g., loose) stools, dizziness, infection, palpitation, pharyngitis, back pain, nausea, peripheral edema, rhinitis, dyspepsia, increased cough, tachycardia.
For Healthcare Professionals
Applies to cilostazol: oral tablet
General
The most frequent adverse reactions resulting in discontinuation of therapy were headache, palpitation, and diarrhea.[Ref]
Nervous system
Very common (10% or more): Headache (up to 34%), dizziness (up to 10%)
Frequency not reported: Tinnitus
Postmarketing reports: Intracranial hemorrhage, cerebral hemorrhage, cerebrovascular accident, extradural hematoma, subdural hematoma
Gastrointestinal
Very common (10% or more): Diarrhea (up to 19%), abnormal stools (up to 15%)
Common (1% to 10%): Dyspepsia, abdominal pain
Frequency not reported: Melena
Postmarketing reports: Gastrointestinal hemorrhage, vomiting, flatulence, nausea[Ref]
Immunologic
Very common (10% or more): Infection (up to 14%)
Postmarketing reports: Anaphylaxis, angioedema, hypersensitivity[Ref]
Respiratory
Very common (10% or more): Rhinitis (up to 12%), pharyngitis (up to 10%)
Frequency not reported: Epistaxis
Postmarketing reports: Pulmonary hemorrhage, interstitial pneumonia[Ref]
Cardiovascular
Very common (10% or more): Palpitation (up to 10%)
Common (1% to 10%): Tachycardia
Frequency not reported: Atrial fibrillation, heart failure, myocardial infarction, nodal arrhythmia, supraventricular tachycardia, ventricular extrasystoles, ventricular tachycardia, left ventricular outflow obstruction
Postmarketing reports: Torsade de pointes, QTc prolongation, angina pectoris, hot flushes, blood pressure increased, subacute stent thrombosis, hypertension[Ref]
Other
Common (1% to 10%): Peripheral edema
Frequency not reported: Fever, generalized edema, malaise
Postmarketing reports: Pain, chest pain[Ref]
Metabolic
Frequency not reported: Anorexia, hyperuricemia
Postmarketing reports: Blood glucose increased, blood uric acid increased[Ref]
Ocular
Frequency not reported: Conjunctivitis, retinal hemorrhage[Ref]
Dermatologic
Frequency not reported: Urticaria
Postmarketing reports: Subcutaneous hemorrhage, pruritus, skin eruptions, Stevens-Johnson syndrome, skin drug eruption, rash[Ref]
Hematologic
Frequency not reported: Anemia
Postmarketing reports: Aplastic anemia, granulocytopenia, pancytopenia, bleeding tendency[Ref]
Genitourinary
Frequency not reported: Urinary frequency
Postmarketing reports: Hematuria[Ref]
Renal
Frequency not reported: Creatinine increased
Postmarketing reports: BUN increased[Ref]
Psychiatric
Frequency not reported: Insomnia[Ref]
Hepatic
Postmarketing reports: Hepatic dysfunction, abnormal liver function tests, jaundice[Ref]
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- Drug class: miscellaneous cardiovascular agents
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References
1. "Product Information. Pletal (cilostazol)." Otsuka American Pharmaceuticals Inc (2001):
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.