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Generic Name: cilostazol (sye LOE sta zol)
Brand Name: Pletal

Medically reviewed by on Jul 29, 2019 – Written by Cerner Multum

What is Pletal?

Pletal is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This medicine dilates arteries that supply blood to your legs. This medicine also improves circulation by keeping platelets in the blood from sticking together and clotting.

Pletal is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. This medicine improves your ability to walk longer distances without pain.

Pletal may also be used for purposes not listed in this medication guide.

Important Information

Do not take Pletal if you have congestive heart failure.

Before taking this medicine

Do not take Pletal if you have congestive heart failure. This medicine can make this condition worse.

To make sure Pletal is safe for you, tell your doctor if you have:

  • liver or kidney disease;

  • heart disease; or

  • if you smoke.

It is not known whether Pletal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether cilostazol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take Pletal?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Pletal is usually taken twice a day on an empty stomach, at least 30 minutes before or 2 hours after breakfast or dinner.

Take the medicine at the same time each day.

It may take up to 12 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Pletal?

Grapefruit and grapefruit juice may interact with Pletal and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Pletal side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest pain, pounding heartbeats or fluttering in your chest;

  • a light-headed feeling, like you might pass out;

  • fever, chills, body aches, flu symptoms;

  • bloody urine, painful urination;

  • shortness of breath, even with mild exertion; or

  • swelling of your ankles or feet.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Pletal?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can interact with Pletal. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.