Pletal Side Effects

Generic name: cilostazol

Medically reviewed by Drugs.com. Last updated on Feb 5, 2025.

Note: This document provides detailed information about Pletal Side Effects associated with cilostazol. Some dosage forms listed on this page may not apply specifically to the brand name Pletal.

Applies to cilostazol: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Cilostazol is contraindicated in congestive heart failure of any severity.

Cilostazol and many of its metabolites inhibit phosphodiesterase III.

Several drugs with this pharmacologic effect have resulted in decreased survival compared with placebo in patients with class III to IV congestive heart failure.

Serious side effects of Pletal

Along with its needed effects, cilostazol (the active ingredient contained in Pletal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cilostazol:

More common side effects

• fast or irregular heartbeat
• fever

Less common side effects

• abnormal bleeding
• bloody or black tarry stools
• bruises or red spots on the skin
• fainting
• nausea, heartburn, or indigestion (severe or continuing)
• nosebleeds
• stiff neck
• stomach pain, cramping, or burning (severe)
• swelling of the tongue
• vomiting of blood or material that looks like coffee grounds

Incidence not known

• bleeding gums
• bleeding tendency
• blistering, peeling, loosening of the skin
• blood in the urine or stools
• blurred vision
• chest pain
• chills
• clay-colored stools
• confusion
• cough or hoarseness
• coughing up blood
• dark urine
• diarrhea
• difficulty with breathing
• drowsiness
• fever with or without chills
• general feeling of tiredness or weakness
• headache, sudden and severe
• inability to speak
• itching of the eyes
• itching of the skin
• joint or muscle pain
• light-colored stools
• loss of appetite
• loss of consciousness
• lower back or side pain
• nausea and vomiting
• painful or difficult urination
• pinpoint red spots on the skin
• red skin lesions, often with a purple center
• red, irritated eyes
• seizures
• skin rash
• slurred speech
• sores, ulcers, or white spots on the lips or in the mouth
• stomach pain
• swollen glands
• temporary blindness
• unpleasant breath odor
• unusual bleeding or bruising
• unusual tiredness or weakness
• weakness in the arm or leg on one side of the body, sudden and severe
• weakness of part of the body
• yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking cilostazol:

Symptoms of overdose

• dizziness or lightheadedness when getting up suddenly from a lying or sitting position

Other side effects of Pletal

Some side effects of cilostazol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common side effects

• back pain
• dizziness
• gas
• headache
• increased cough
• pain or stiffness in the muscles
• pounding heartbeat
• runny or stuffy nose
• sore throat
• swelling of the arms or legs

Less common

• bone pain
• burning feeling in the throat or chest
• difficulty with swallowing
• hives
• pain or stiffness in the joints
• ringing or buzzing in the ears
• swelling of the face, fingers, or lower legs

Incidence not known

• bruising
• feeling of warmth
• pain
• redness of the face, neck, arms and occasionally, upper chest

For healthcare professionals

Applies to cilostazol: oral tablet.

General adverse events

The most frequent adverse reactions resulting in discontinuation of therapy were headache, palpitation, and diarrhea.^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 34%), dizziness (up to 10%)
• Frequency not reported: Tinnitus
• Postmarketing reports: Intracranial hemorrhage, cerebral hemorrhage, cerebrovascular accident, extradural hematoma, subdural hematoma

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 19%), abnormal stools (up to 15%)
• Common (1% to 10%): Dyspepsia, abdominal pain
• Frequency not reported: Melena
• Postmarketing reports: Gastrointestinal hemorrhage, vomiting, flatulence, nausea^[Ref]

Immunologic

• Very common (10% or more): Infection (up to 14%)
• Postmarketing reports: Anaphylaxis, angioedema, hypersensitivity^[Ref]

Respiratory

• Very common (10% or more): Rhinitis (up to 12%), pharyngitis (up to 10%)
• Frequency not reported: Epistaxis
• Postmarketing reports: Pulmonary hemorrhage, interstitial pneumonia^[Ref]

Cardiovascular

• Very common (10% or more): Palpitation (up to 10%)
• Common (1% to 10%): Tachycardia
• Frequency not reported: Atrial fibrillation, heart failure, myocardial infarction, nodal arrhythmia, supraventricular tachycardia, ventricular extrasystoles, ventricular tachycardia, left ventricular outflow obstruction
• Postmarketing reports: Torsade de pointes, QTc prolongation, angina pectoris, hot flushes, blood pressure increased, subacute stent thrombosis, hypertension^[Ref]

Other

• Common (1% to 10%): Peripheral edema
• Frequency not reported: Fever, generalized edema, malaise
• Postmarketing reports: Pain, chest pain^[Ref]

Metabolic

• Frequency not reported: Anorexia, hyperuricemia
• Postmarketing reports: Blood glucose increased, blood uric acid increased^[Ref]

Ocular

• Frequency not reported: Conjunctivitis, retinal hemorrhage^[Ref]

Dermatologic

• Frequency not reported: Urticaria
• Postmarketing reports: Subcutaneous hemorrhage, pruritus, skin eruptions, Stevens-Johnson syndrome, skin drug eruption, rash^[Ref]

Hematologic

• Frequency not reported: Anemia
• Postmarketing reports: Aplastic anemia, granulocytopenia, pancytopenia, bleeding tendency^[Ref]

Genitourinary

• Frequency not reported: Urinary frequency
• Postmarketing reports: Hematuria^[Ref]

Renal

• Frequency not reported: Creatinine increased
• Postmarketing reports: BUN increased^[Ref]

Psychiatric

• Frequency not reported: Insomnia^[Ref]

Hepatic

• Postmarketing reports: Hepatic dysfunction, abnormal liver function tests, jaundice^[Ref]

Further information

Pletal side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer