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Cilostazol Dosage

Medically reviewed by Drugs.com. Last updated on Jul 28, 2017.

Applies to the following strengths: 50 mg; 100 mg

Usual Adult Dose for Intermittent Claudication

100 mg orally twice a day at least 30 minutes before or 2 hours after breakfast and dinner

Comments:
-Patients may respond as early as 2 to 4 weeks after initiation of therapy, but treatment for up to 12 weeks may be required before a beneficial effect is experienced.
-If symptoms remain unimproved after 3 months, discontinue this drug.

Use: Reduction of symptoms of intermittent claudication, as demonstrated by an increased walking distance.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild liver dysfunction: No adjustment recommended.
Moderate to severe liver dysfunction: Dosage adjustment(s) may be required; however, no specific guidelines have been suggested.

Dose Adjustments

Coadministration with strong or moderate inhibitors of CYP450 3A4 (e.g., diltiazem, erythromycin, itraconazole, ketoconazole) or inhibitors of CYP450 2C19 (e.g., fluconazole, omeprazole, ticlopidine): Reduce cilostazol dose to 50 mg orally twice a day

Precautions

US BOXED WARNING:
-CONTRAINDICATED IN HEART FAILURE PATIENTS: This drug is contraindicated in patients with heart failure of any severity. This drug and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III to IV heart failure.

CONTRAINDICATIONS:
-Hypersensitivity (e.g., anaphylaxis, angioedema) to the active component or any of the ingredients
-Heart failure of any severity

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Monitoring:
-Cardiovascular: Monitor for the development of a new systolic murmur or cardiac symptoms.
-Hematologic: Platelets and white blood cell counts periodically.

Patient advice:
-Advise patients to promptly report any episode of bleeding or easy bruising or any other signs which might suggest early development of blood dyscrasia (e.g., pyrexia, sore throat).
-This drug may cause drowsiness; exercise caution before driving or operating machinery.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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