Bynfezia Pen Side Effects

Generic name: octreotide

Medically reviewed by Drugs.com. Last updated on Aug 21, 2024.

Note: This document provides detailed information about Bynfezia Pen Side Effects associated with octreotide. Some dosage forms listed on this page may not apply specifically to the brand name Bynfezia Pen.

Applies to octreotide: powder for suspension, solution.

Other dosage forms:

• oral capsule delayed release

Serious side effects of Bynfezia Pen

Along with its needed effects, octreotide (the active ingredient contained in Bynfezia Pen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking octreotide:

More common

• constipation
• depressed mood
• diarrhea
• dizziness
• dry skin and hair
• fainting
• fast, slow, or irregular heartbeat
• feeling cold
• hair loss
• hoarseness or husky voice
• loss of appetite
• muscle cramps and stiffness
• nausea
• severe stomach pain with nausea and vomiting
• stomach pain
• unusual tiredness or weakness
• vomiting
• weight gain

Less common

• anxiety
• bladder pain
• bloody or cloudy urine
• blurred vision
• chills
• cold sweats
• collection of blood under the skin
• confusion
• cool, pale skin
• deep, dark purple bruise
• difficult, burning, or painful urination
• dry mouth
• flushed, dry skin
• frequent urge to urinate
• fruit-like breath odor
• headache
• increased hunger
• increased thirst
• increased urination
• itching, pain, redness, or swelling
• loss of consciousness
• lower back or side pain
• nervousness
• nightmares
• seizures
• shakiness
• slurred speech
• sweating
• swelling
• trouble breathing
• unexplained weight loss

Rare

• black, tarry stools
• bleeding gums
• blood in vomit
• changes in skin color, pain, tenderness, swelling of the foot or leg
• chest pain or tightness
• cough
• coughing up blood
• dark urine
• decreased urine output
• difficulty in breathing or swallowing
• difficulty swallowing
• dilated neck veins
• extreme tiredness or weakness
• fast, irregular, pounding, or racing heartbeat or pulse
• fever
• hives, itching, skin rash
• increased menstrual flow or vaginal bleeding
• irregular breathing
• itching, pain, redness, swelling, tenderness, or warmth on the skin
• light-colored stools
• nosebleeds
• pain in the groin or genitals
• pale skin
• paleness or cold feeling in the fingertips and toes
• paralysis
• pounding in the ears
• prolonged bleeding from cuts
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• red or dark brown urine
• severe or continuing stomach pain
• sharp back pain just below the ribs
• sneezing
• sore throat
• swelling of the face, fingers, feet, or lower legs
• tingling or pain in the fingers or toes when exposed to cold temperatures
• tremor
• unusual bleeding or bruising
• upper right abdominal or stomach pain
• yellow eyes and skin

Incidence not known

• blindness
• bloating
• clear or bloody discharge from nipple
• decreased vision
• delusions of persecution, mistrust, suspiciousness, and/or combativeness
• dimpling of the breast skin
• eye pain
• gaseous
• indigestion
• inverted nipple
• lump in the breast or under the arm
• pain or discomfort in the arms, jaw, back, or neck
• pains in the stomach, side, or abdomen, possibly radiating to the back
• persistent crusting or scaling of the nipple
• pinpoint red spots on the skin
• recurrent fever
• redness of swelling of the breast
• severe constipation
• severe cramping
• sore on the skin of the breast that does not heal
• sores, ulcers, or white spots on the lips or in the mouth
• stomach fullness
• swollen glands
• tearing
• weakness of the muscles in your face

Get emergency help immediately if any of the following symptoms of overdose occur while taking octreotide:

Symptoms of overdose

• anxiety
• blurred vision
• chills
• cold sweats
• coma
• confusion
• cool, pale skin
• depression
• dizziness
• fast heartbeat
• feeling of warmth
• headache
• increased hunger
• nausea
• nervousness
• nightmares
• redness of the face, neck, arms and occasionally, upper chest
• seizures
• shakiness
• slurred speech
• unusual tiredness or weakness

Other side effects of Bynfezia Pen

Some side effects of octreotide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• abnormal stool
• excess air or gas in the stomach or bowels
• full feeling
• pain, redness, stinging, swelling, tingling, or burning sensation at the injection site
• passing of gas

Less common

• backache
• feeling of warmth
• hair loss
• joint pain
• redness of the face, neck, arms and occasionally, upper chest

Rare

• absent, missed, or irregular menstrual periods
• change in vision
• difficulty in moving
• feeling of constant movement of self or surroundings
• hearing loss
• itching of the vagina or genital area
• joint swelling or redness
• loss of vision
• memory loss
• muscle pain
• numbness or tingling of the hands, feet, or face
• pain during sexual intercourse
• sensation of spinning
• stopping of menstrual bleeding
• swelling of the breasts or breast soreness in both females and males
• thick, white vaginal discharge with no odor or with a mild odor
• unexpected or excess milk flow from the breasts

Incidence not known

• decreased interest in sexual intercourse
• inability to have or keep an erection
• loss in sexual ability, desire, drive, or performance
• unexpected or excess milk flow from the breasts

For healthcare professionals

Applies to octreotide: injectable solution, intramuscular powder for injection extended release, oral delayed release capsule, subcutaneous solution.

General

The most common adverse events were gastrointestinal disorders, nervous system disorders, hepatobiliary disorders, and metabolism and nutritional disorders.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (57.9%), abdominal pain (43.9%), nausea (29.8%), flatulence (25.3%), constipation (18.8%), abdominal pain upper (10.5%), abdominal discomfort, loose stools
• Common (1% to 10%): Fat malabsorption, vomiting, dyspepsia, steatorrhea, discoloration of feces, tenesmus, abdominal distension
• Uncommon (0.1% to 1%): GI bleeding, hemorrhoids, appendicitis, gastric/peptic ulcer
• Frequency not reported: Pancreatitis, vomiting, abnormal stools, severe epigastric pain, abdominal tenderness and guarding
• Postmarketing reports: Intestinal obstruction^[Ref]

Cardiovascular

• Very common (10% or more): Bradycardia (25%), hypertension (12.6%), conduction abnormalities (10%)
• Common (1% to 10%): Arrhythmias, flushing
• Uncommon (0.1% to 1%): Chest pain, shortness of breath, thrombophlebitis, ischemia, congestive heart failure, palpitations, orthostatic blood pressure decrease, tachycardia^[Ref]

Hepatic

• Very common (10% or more): Gallstones (27%), sludge without stones (24%), cholelithiasis (38.2%), biliary duct dilatation (12%)
• Common (1% to 10%): Transaminase increased
• Uncommon (0.1% to 1%): Hepatitis, jaundice, increase in liver enzymes, gallbladder polyp
• Rare (less than 0.1%): Acute pancreatitis
• Frequency not reported: Acute cholecystitis, ascending cholangitis, biliary obstruction, cholestatic hepatitis, pancreatitis^[Ref]

Nervous system

• Very common (10% or more): Headache (30%), dizziness (20%)
• Uncommon (0.1% to 1%): Syncope, tremor, seizure, vertigo, Bell's palsy, pituitary apoplexy, amnesia, neuritis^[Ref]

Metabolic

• Very common (10% or more): Hyperglycemia (16%)
• Common (1% to 10%): Hypoglycemia, edema, anorexia
• Uncommon (0.1% to 1%): Weight loss, dehydration
• Frequency not reported: Depressed vitamin B12 levels, abnormal Schilling's test^[Ref]

Hematologic

• Very common (10% or more): Anemia (15.3%)
• Uncommon (0.1% to 1%): Iron deficiency
• Postmarketing reports: Thrombocytopenia^[Ref]

Endocrine

• Very common (10% or more): Biochemical hypothyroidism (12%)
• Common (1% to 10%): Goiter, thyroid dysfunction (e.g. decreased TSH, decreased Total T4, and decreased Free T4)
• Uncommon (0.1% to 1%): Galactorrhea, hypoadrenalism, diabetes insipidus^[Ref]

Local

• Very common (10% or more): Injection site pain (13.8%), injection site reactions
• Common (1% to 10%): Injection site hematoma^[Ref]

Dermatologic

• Very common (10% or more): Alopecia (13.2%)
• Common (1% to 10%): Pruritus, bruise, rash
• Uncommon (0.1% to 1%): Cellulitis, petechiae, urticaria, basal cell carcinoma^[Ref]

Musculoskeletal

• Common (1% to 10%): Joint pain, backache
• Uncommon (0.1% to 1%): Arthritis, joint effusion, muscle pain, Raynaud's phenomenon^[Ref]

Psychiatric

• Common (1% to 10%): Depression
• Uncommon (0.1% to 1%): Anxiety, paranoia, libido decrease^[Ref]

Other

• Very common (10% or more): Fatigue (31.8%), generalized pain (15%)
• Common (1% to 10%): Weakness
• Uncommon (0.1% to 1%): Hearing loss, otitis^[Ref]

Respiratory

• Very common (10% or more): Upper respiratory tract infection (18.2%), sinusitis (12%)
• Common (1% to 10%): Cold symptoms, flu symptoms, epistaxis
• Uncommon (0.1% to 1%): Pneumonia, pulmonary nodule, status asthmaticus^[Ref]

Renal

• Uncommon (0.1% to 1%): Increased creatinine kinase^[Ref]

Hypersensitivity

• Uncommon (0.1% to 1%): Allergic reaction
• Frequency not reported: Anaphylactic reaction^[Ref]

Immunologic

• Very common (10% or more): Antibodies to octreotide (the active ingredient contained in Bynfezia Pen) (25%)

Ocular

• Common (1% to 10%): Blurred vision, visual disturbance
• Uncommon (0.1% to 1%): Increased intraocular pressure^[Ref]

Genitourinary

• Common (1% to 10%): Urinary tract infection, pollakiuria
• Uncommon (0.1% to 1%): Gynecomastia, amenorrhea, polymenorrhea, oligomenorrhea, vaginitis, nephrolithiasis, hematuria^[Ref]

Further information

Bynfezia Pen side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer