Skip to main content

Belumosudil Side Effects

Medically reviewed by Last updated on Apr 14, 2024.

Applies to belumosudil: oral tablet.

Serious side effects of Belumosudil

Along with its needed effects, belumosudil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking belumosudil:

More common

Other side effects of Belumosudil

Some side effects of belumosudil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to belumosudil: oral tablet.


The most common adverse reactions occurring in 20% or more patients, including laboratory abnormalities, were infections, asthenia, nausea, diarrhea, dyspnea, cough, edema, hemorrhage, abdominal pain, musculoskeletal pain, headache, decreased phosphate, increased gamma-glutamyl transferase, decreased lymphocytes, and hypertension.[Ref]


Very common (10% or more): Hypertension (up to 21%)[Ref]


Very common (10% or more): Rash (up to 12%), pruritus/generalized pruritus (11%)[Ref]

Rash includes maculopapular rash, erythematous rash, generalized rash, and exfoliative dermatitis.[Ref]


Very common (10% or more): Nausea/vomiting (up to 42%), diarrhea (up to 35%), upper/lower abdominal pain (up to 22%), dysphasia (up to 16%)

Common (1% to 10%): Constipation[Ref]


Very common (10% or more): Hemorrhage (up to 23%), decreased neutrophil count (up to 83%), decreased platelets (up to 82%), decreased hemoglobin (up to 79%), decreased lymphocytes (up to 62%)[Ref]

Hemorrhage includes contusion, hematoma, epistaxis, increased tendency to bruise, conjunctival hemorrhage, hematochezia, mouth hemorrhage, catheter site hemorrhage, hematuria, hemothorax, and purpura.[Ref]


Very common (10% or more): Increased gamma-glutamyl transferase (up to 47%)

Common (1% to 10%): Increased AST, increased ALT[Ref]


Very common (10% or more): Decreased appetite (up to 17%)[Ref]


Very common (10% or more): Musculoskeletal pain (up to 22%), arthralgia (up to 15%)

Common (1% to 10%): Muscle spasm[Ref]

Musculoskeletal pain includes pain in extremity, back pain, flank pain, limb discomfort, musculoskeletal chest pain, and neck pain.[Ref]

Nervous system

Very common (10% or more): Headache/migraine (up to 21%)

Common (1% to 10%): Peripheral neuropathy, dizziness[Ref]


Very common (10% or more): Decreased calcium (up to 82%), increased potassium (up to 82%), increased alkaline phosphatase (up to 80%), decreased phosphate (up to 76%), asthenia/fatigue/malaise (up to 46%), edema (up to 27%), pyrexia (up to 18%), infection (unspecified pathogen) (up to 53%), viral infection (up to 19%), bacterial infection (up to 16%)[Ref]

Edema includes peripheral edema, generalized edema, face edema, and localized edema.

Infection with unspecified pathogens includes acute sinusitis, device-related infection, ear infection, folliculitis, gastroenteritis, gastrointestinal infection, hordeolum, infectious colitis, lung infection, skin infection, tooth infection, urinary tract infection, wound infection, upper respiratory tract infection, pneumonia, conjunctivitis, sinusitis, respiratory tract infection, bronchitis, sepsis, and septic shock.

Viral infection includes influenza, rhinovirus infection, gastroenteritis viral, viral upper respiratory tract infection, bronchitis viral, Epstein-Barr viremia, Epstein-Barr virus infection, parainfluenza virus infection, and Varicella zoster virus infection.

Bacterial infection includes cellulitis, Helicobacter infection, Staphylococcal bacteremia, catheter site cellulitis, Clostridium difficile colitis, Escherichia urinary tract infection, gastroenteritis Escherichia coli, Pseudomonas infection, and bacterial urinary tract infection.[Ref]


Very common (10% or more): Increased creatinine (up to 83%)[Ref]


Very common (10% or more): Dyspnea (up to 33%), cough/productive cough (up to 30%), nasal congestion (up to 12%)[Ref]

Dyspnea includes exertional dyspnea, apnea, orthopnea, and sleep apnea syndrome.[Ref]


1. (2021) "Product Information. Rezurock (belumosudil)." Kadmon Pharmaceuticals

2. (2024) "Product Information. Rezurock (belumosudil)." Sanofi

3. (2024) "Product Information. Rezurock (belumosudil)." Kadmon Pharmaceuticals, 11/2023

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.