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Amytal Sodium Side Effects

Generic name: amobarbital

Medically reviewed by Last updated on Mar 14, 2024.

Note: This document contains side effect information about amobarbital. Some dosage forms listed on this page may not apply to the brand name Amytal Sodium.

Applies to amobarbital: injection solution reconstituted.

Serious side effects of Amytal Sodium

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Other side effects of Amytal Sodium

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to amobarbital: compounding powder, injectable powder for injection.


The most commonly reported side effect was somnolence.[Ref]

Nervous system

Common (1% to 10%): Somnolence

Frequency not reported: Ataxia, central nervous system (CNS) depression, dizziness, headache, hyperkinesia, syncope[Ref]


Frequency not reported: Abnormality in thinking, agitation, anxiety, confusion, hallucinations, insomnia, nervousness, nightmares, psychiatric disturbance[Ref]


Frequency not reported: Apnea, hypoventilation, postoperative atelectasis[Ref]


Frequency not reported: Constipation, nausea, vomiting[Ref]


Frequency not reported: Bradycardia, hypotension[Ref]


Frequency not reported: Angioedema, hypersensitivity reactions[Ref]


Frequency not reported: Exfoliative dermatitis, skin rashes[Ref]


Frequency not reported: Liver damage[Ref]


Frequency not reported: Megaloblastic anemia[Ref]


Frequency not reported: Injection site reactions[Ref]


Frequency not reported: Fever[Ref]


1. (2001) "Product Information. Amytal Sodium (amobarbital)." Lilly, Eli and Company

2. (2010) "Product Information. Amytal Sodium (amobarbital)." Marathon Pharmaceuticals

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.