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Ameluz Side Effects

Generic Name: aminolevulinic acid topical

Note: This page contains information about the side effects of aminolevulinic acid topical. Some of the dosage forms included on this document may not apply to the brand name Ameluz.

For the Consumer

Applies to aminolevulinic acid topical: topical gel/jelly, topical kit, topical solution, topical stick

In addition to its needed effects, some unwanted effects may be caused by aminolevulinic acid topical (the active ingredient contained in Ameluz). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking aminolevulinic acid topical:

More common:
  • Pain, burning, itching, redness, or swelling at the application site
Less common:
  • Bleeding during lesion preparation
Incidence not known:
  • difficulty seeing at night
  • double vision
  • increased sensitivity of the eyes to sunlight
  • red, sore eyes
  • seeing double
  • swelling of the eyelids

Minor Side Effects

Some of the side effects that can occur with aminolevulinic acid topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Burning, crawling, itching, numbness, prickling, “pins and needles,” stinging, or tingling feelings
  • darkening of the treated skin
  • lightening of the treated skin
  • scaling or crusting
  • skin sore
  • small red raised itchy bumps
  • swelling of the skin
Less common:
  • Blister
  • oozing
  • open sore on the skin
  • pain
  • pus filled blister or pimple
  • raw skin
  • scabbing
  • tenderness

For Healthcare Professionals

Applies to aminolevulinic acid topical: topical gel, topical solution


The most commonly reported side effects were scaling/crusting, hypo-/hyper-pigmentation, and itching.[Ref]


Very common (10% or more): Scaling/Crusting (up to 71%), hypo-/hyper-pigmentation (up to 36%), erosion (up to 14%), itching (up to 25%), pruritus
Common (1% to 10%): Wheal/flare, skin disorders NOS, ulceration, bleeding/hemorrhage, vesiculation, pustules, dysesthesia, scabbing, excoriation, oozing, skin tightness
Uncommon (0.1% to 1%): Pustular rash, dry skin, petechiae, hyperkeratosis[Ref]


Very Common (10% or more): Irritation, erythema, pain, edema, exfoliation, induration
Common (1% to 10%): Pain, tenderness, ulceration
Uncommon (0.1% to 1%): Discharge, discoloration, ulcer, chills, feeling hot, pyrexia, wound secretion

Nervous system

Common (1% to 10%): Headache, paraesthesia, hyperalgesia[Ref]


Uncommon (0.1% to 1%): Eyelid edema[Ref]


Uncommon (0.1% to 1%): Nervousness[Ref]


1. "Product Information. Levulan Kerastick (aminolevulinic acid)" Berlex, Richmond, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Ameluz may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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