Alphanate Side Effects
Generic Name: antihemophilic factor / von willebrand factor
Medically reviewed by Drugs.com. Last updated on Aug 29, 2020.
Note: This document contains side effect information about antihemophilic factor / von willebrand factor. Some of the dosage forms listed on this page may not apply to the brand name Alphanate.
For the Consumer
Applies to antihemophilic factor / von willebrand factor: intravenous powder for solution
Side effects requiring immediate medical attention
Along with its needed effects, antihemophilic factor / von willebrand factor may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking antihemophilic factor / von willebrand factor:
- Difficulty with breathing or swallowing
- fast heartbeat
- hives or welts, itching, rash
- reddening of the skin, especially around the ears
- swelling of the face, throat, or tongue
- unusual tiredness or weakness
Incidence not known
- Abdominal or stomach pain
- blurred vision
- pounding in the ears
- slow or fast heartbeat
- tightness in the chest
For Healthcare Professionals
Applies to antihemophilic factor / von willebrand factor: intravenous powder for injection
Common (1% to 10%): Allergy, infection, hypersensitivity
Uncommon (0.1% to 1%): Factor VIII inhibition
Very rare (less than 0.01%): Von Willebrand factor inhibition, anaphylactic shock
Very common (10% or more): Pain (up to 17.5%)
Common (1% to 10%): Fever, surgery, facial edema, chest pain, peripheral edema, rigors
Frequency not reported: Chills, pseudothrombocytopenia, postoperative pain
Postmarketing reports: Fatigue, malaise[Ref]
Very common (10% or more): Nausea (up to 23.8%), constipation (11.1%)
Common (1% to 10%): Gastrointestinal bleeding, abdominal pain, vomiting
Frequency not reported: Postoperative nausea[Ref]
Common (1% to 10%): Groin bleed, ear bleed, shoulder bleed, anemia/hemoglobin decreased, thromboembolic event
Frequency not reported: Hemorrhage, hematocrit decreased, postoperative hemorrhage, postoperative wound bleeding
Postmarketing reports: Hemolysis[Ref]
Common (1% to 10%): Cerebral hemorrhage/subdural hematoma, dizziness, headache, dysgeusia, somnolence
Frequency not reported: Headache, paresthesia, drowsiness[Ref]
Common (1% to 10%): Epistaxis, hemoptysis, pulmonary embolus, sore throat
Frequency not reported: Respiratory distress
Common (1% to 10%): ALT increased, liver function test abnormal[Ref]
Common (1% to 10%): Back pain, muscle and joint stiffness
Frequency not reported: Extremity pain
Postmarketing reports: Joint pain[Ref]
Common (1% to 10%): Thrombophlebitis
Common (1% to 10%): Infusion site erythema or rash or pain
Frequency not reported: Injection site bleeding
Postmarketing reports: Infusion site pain[Ref]
Frequency not reported: Blurred vision[Ref]
Frequency not reported: Pyelonephritis[Ref]
Postmarketing reports: Hypervolemia[Ref]
1. "Product Information. Alphanate (antihemophilic factor-von Willebrand factor)." Alpha Therapeutic Corporation, Los Angeles, CA.
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
4. "Product Information. Humate-P (antihemophilic factor-von Willebrand factor)." CSL Behring, King of Prussia, PA.
5. "Product Information. Wilate (antihemophilic factor-von Willebrand factor)." Octapharma USA, Centreville, VA.
More about Alphanate (antihemophilic factor / von willebrand factor)
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: miscellaneous coagulation modifiers
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.