Skip to main content

DDAVP (injection)

Generic name: desmopressin (injection) [ DEZ-mo-press-in ]
Brand name: DDAVP
Drug class: Antidiuretic hormones

Medically reviewed by on Aug 16, 2023. Written by Cerner Multum.

What is DDAVP?

DDAVP is a man-made form of a hormone that occurs naturally in the pituitary gland. This hormone is important for many functions including blood flow, blood pressure, kidney function, and regulating how the body uses water.

DDAVP is used to treat bleeding episodes in people with hemophilia A or von Willebrand's disease Type I.

DDAVP is also used to treat central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma.

DDAVP may also be used for purposes not listed in this medication guide.

DDAVP side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

DDAVP may cause serious side effects. Call your doctor at once if you have:

Common side effects of DDAVP may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


You should not use this medication if you have severe kidney disease or if you have ever had hyponatremia (low sodium levels in your body).

You may not be able to use DDAVP if you have uncontrolled high blood pressure, severe heart failure, severe kidney disease, a condition called SIADH (syndrome of inappropriate antidiuretic hormone secretion), or any condition that causes excessive thirst, dehydration, or an electrolyte imbalance.

Call your doctor right away if you have signs of low sodium: headache, confusion, muscle cramps, severe weakness, vomiting, loss of coordination, and feeling restless or unsteady.

Limit your intake of water and other fluids while you are using DDAVP. Drinking too much water can cause your body to lose sodium, which may lead to a serious, life-threatening electrolyte imbalance.

Before taking this medicine

You should not use DDAVP if you are allergic to DDAVP, or if you have:

To make sure DDAVP is safe for you, tell your doctor if you have:

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether desmopressin passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

How is injectable DDAVP given?

Your doctor may perform blood tests to make sure you do not have conditions that would prevent you from safely using DDAVP.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

DDAVP is injected under the skin, or into a vein through an IV. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

DDAVP is also available as a nasal spray. If you were switched from this medicine nasal to this medicine, your dosage needs will change. The this medicine dose is much lower than the this medicine nasal dose. Follow your doctor's dosing instructions very carefully.

While using DDAVP, your blood pressure will need to be checked often and you may need frequent blood tests.

Limit your intake of water and other fluids while you are using DDAVP. Drinking too much water can cause your body to lose sodium, which may lead to a serious, life-threatening electrolyte imbalance.

Fluid restriction is especially important in children and older adults using DDAVP. Follow your doctor's instructions about the type and amount of liquids you should drink.

Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.

If you are treating hemophilia or von Willebrand's disease, get medical attention if your bleeding is not controlled during treatment with DDAVP.

Store this medicine in the refrigerator. Do not freeze.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, confusion, drowsiness, rapid weight gain, or urination problems.

What should I avoid while using DDAVP?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect DDAVP?

Tell your doctor about all your current medicines and any you start or stop using, especially:

This list is not complete. Other drugs may interact with desmopressin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Popular FAQ

Noctiva (desmopressin acetate) is a nasal spray used to treat waking in the night because you have to urinate (nocturia) that is caused by increased nighttime production of urine (nocturnal polyuria).

Noctiva is a vasopressin analog that helps the kidneys to reabsorb more water, causing urine production to reduce and helping to alleviate the need to pee. Continue reading

More FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.