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Alectinib Side Effects

In Summary

Commonly reported side effects of alectinib include: cough, dyspnea, increased creatine phosphokinase, increased serum aspartate aminotransferase, musculoskeletal pain, and myalgia. Other side effects include: bradycardia, and increased serum bilirubin. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to alectinib: oral capsule

Along with its needed effects, alectinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alectinib:

More common
  • Chest pain or discomfort
  • cough
  • difficulty with moving
  • joint pain
  • lightheadedness, dizziness, or fainting
  • muscle aching or cramping
  • muscle pains or stiffness
  • shortness of breath
  • slow or irregular heartbeat
  • swollen joints
  • unusual tiredness
Less common
  • Abdominal pain or tenderness
  • clay colored stools
  • dark urine
  • decreased appetite
  • fever
  • headache
  • itching or skin rash
  • loss of appetite
  • nausea and vomiting
  • swelling of the feet or lower legs
  • yellow eyes or skin
Rare
  • Difficult breathing
  • fever

Some side effects of alectinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blurred vision
  • difficulty having a bowel movement (stool)
  • double vision
  • lack or loss of strength
  • rapid weight gain
  • rash with flat lesions or small raised lesions on the skin
  • seeing double
  • seeing floating dark spots or material before the eyes
  • swelling around the eyes
  • tingling of the hands or feet
  • unusual weight gain or loss
  • vision changes

For Healthcare Professionals

Applies to alectinib: oral capsule

Hematologic

Very common (10% or more): Anemia (56%), lymphopenia (22%)[Ref]

Hepatic

Very common (10% or more): Increased AST (51%), increased alkaline phosphatase (47%), hyperbilirubinemia (39%), increased ALT (34%)[Ref]

Musculoskeletal

Very common (10% or more): Increased CPK (43%), myalgia/musculoskeletal pain (29%), back pain (12%)[Ref]

Other

Very common (10% or more): Fatigue/asthenia (41%), edema (30%)[Ref]

The following types of edema were reported: peripheral, generalized, eyelid, and periorbital.[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (36%), hypocalcemia (32%), hypokalemia (29%), hypophosphatemia (21%), hyponatremia (20%), increased weight (11%)[Ref]

Gastrointestinal

Very common (10% or more): Constipation (34%), nausea (18%), diarrhea (16%), vomiting (12%)[Ref]

Renal

Very common (10% or more): Increased creatinine (28%)[Ref]

Dermatologic

Very common (10% or more): Rash (18%)
Common (1% to 10%): Photosensitivity[Ref]

Reported cases of rash included acneiform dermatitis, erythema, and different types of rash (macular, papular, maculopapular, generalized, and pruritic).[Ref]

Nervous system

Very common (10% or more): Headache (17%)[Ref]

Respiratory

Very common (10% or more): Cough (19%), dyspnea (16%)
Uncommon (0.1% to 1%): Interstitial lung disease[Ref]

Ocular

Reported cases of vision disorder included blurred vision, vitreous floaters, visual impairment, reduced visual acuity, asthenopia, and diplopia.[Ref]

Very common (10% or more): Vision disorder (10%)[Ref]

Cardiovascular

Common (1% to 10%): Bradycardia[Ref]

General

In 253 patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) who received this drug (600 mg orally twice a day) for a median duration of 9.3 months, serious (19%) and fatal (2.8%) adverse reactions occurred.[Ref]

References

1. "Product Information. Alecensa (alectinib)." Genentech, South San Francisco, CA.

Some side effects of alectinib may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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