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Alectinib Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jul 21, 2022.

Summary

Commonly reported side effects of alectinib include: cough, dyspnea, increased creatine phosphokinase in blood specimen, increased serum aspartate aminotransferase, musculoskeletal pain, and myalgia. Other side effects include: bradycardia, and increased serum bilirubin. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to alectinib: oral capsules

Side effects include:

Fatigue, constipation, edema, myalgia, anemia.

For Healthcare Professionals

Applies to alectinib: oral capsule

Hematologic

Very common (10% or more): Anemia (62%), lymphopenia (14%), neutropenia (14%)

Postmarketing reports: Hemolytic anemia[Ref]

Hepatic

Very common (10% or more): Increased AST (51%), increased alkaline phosphatase (47%), hyperbilirubinemia (39%), increased ALT (34%)[Ref]

Musculoskeletal

Very common (10% or more): Increased CPK (43%), myalgia/musculoskeletal pain (29%), back pain (12%), back pain (12%)[Ref]

Other

Very common (10% or more): Fatigue/asthenia (26%), edema (e.g., peripheral edema, edema, eyelid edema, localized edema, face edema) (22%)[Ref]

Metabolic

Very common (10% or more): Hyperglycemia (36%), hypocalcemia (32%), hypokalemia (29%), hypophosphatemia (21%), hyponatremia (20%), increased weight (11%)[Ref]

Gastrointestinal

Very common (10% or more): Constipation (34%), nausea (18%), diarrhea (16%), vomiting (12%)[Ref]

Renal

Very common (10% or more): Increased creatinine (e.g., increased blood creatinine, creatinine renal clearance decreased, glomerular filtration rate decreased, acute kidney injury) (28%)[Ref]

Dermatologic

Very common (10% or more): Rash (e.g., acneiform dermatitis, erythema, and different types of rash [macular, papular, maculopapular, generalized, and pruritic]) (15%)

Common (1% to 10%): Photosensitivity[Ref]

Nervous system

Very common (10% or more): Headache (17%)

Common (1% to 10%): Dysgeusia/hypogeusia[Ref]

Respiratory

Very common (10% or more): Cough (19%), dyspnea (16%)

Uncommon (0.1% to 1%): Interstitial lung disease[Ref]

Ocular

Very common (10% or more): Vision disorder (e.g., blurred vision, vitreous floaters, visual impairment, reduced visual acuity, asthenopia, diplopia) (10%)[Ref]

Cardiovascular

Very common (10% or more): Bradycardia (11%)[Ref]

Frequently asked questions

References

1. "Product Information. Alecensa (alectinib)." Genentech (2015):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.