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Alcaftadine ophthalmic Side Effects

Medically reviewed by Last updated on May 14, 2023.

Applies to alcaftadine ophthalmic: ophthalmic solution.

Serious side effects

Along with its needed effects, alcaftadine ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alcaftadine ophthalmic:

Incidence not known

  • Changes in vision
  • eye pain
  • increased eye redness
  • itching of the eye that worsens or lasts for more than 72 hours

For Healthcare Professionals

Applies to alcaftadine ophthalmic: ophthalmic solution.


The most commonly reported side effects included eye burning, irritation, and/or stinging following irritation.[Ref]


Frequency not reported: Eye burning/irritation/pruritus/redness/stinging upon instillation

Postmarketing reports: Blurred vision, eye discharge, eye swelling, eyelid edema, eyelid erythema, increased lacrimation[Ref]

Nervous system

Frequency not reported: Headache

Postmarketing reports: Somnolence[Ref]


Frequency not reported: Nasopharyngitis[Ref]


Postmarketing reports: Allergic dermatitis, face swelling[Ref]


Postmarketing reports: Hypersensitivity reactions[Ref]


1. "Product Information. Lastacaft (alcaftadine ophthalmic)." Vistakon, div of Johnson and Johnson Optical (2010):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.