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Albiglutide Side Effects

In Summary

Commonly reported side effects of albiglutide include: injection site reaction, diarrhea, and nausea. Other side effects include: vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to albiglutide: subcutaneous powder for solution

In addition to its needed effects, some unwanted effects may be caused by albiglutide. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking albiglutide:

Rare
  • Bloating
  • chills or fever
  • darkened urine
  • fast heartbeat
  • loss of appetite
  • nausea, vomiting, or indigestion
  • pains in the stomach, side, or abdomen, possibly radiating to the back
Incidence not known:
  • Anxiety, irritability, or mood changes
  • blurred vision
  • cold sweats
  • confusion
  • difficulty with breathing or swallowing
  • dizziness
  • headache
  • increased hunger
  • shakiness
  • skin itching, rash, or redness
  • slurred speech
  • swelling of the face, throat, or tongue
  • unusual tiredness or weakness

Minor Side Effects

Some of the side effects that can occur with albiglutide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Body aches or pain
  • cough
  • diarrhea
  • ear congestion
  • loss of voice
  • muscle pain or stiffness
  • pain in the joints
  • pain or tenderness around the eyes and cheekbones
  • skin reactions, warmth, or redness at the injection site
  • sneezing
  • stuffy or runny nose

For Healthcare Professionals

Applies to albiglutide: subcutaneous powder for injection

Gastrointestinal

Very common (10% or more): Diarrhea (13.1%), nausea (11.1%),
Common (1% to 10%): Vomiting, gastroesophageal reflux disease, dyspepsia, constipation
Uncommon (0.1% to 1%): Appendicitis, acute pancreatitis[Ref]

Immunologic

Very common (10% or more): Positive test for anti-albiglutide antibodies[Ref]

Local

Very common (10% or more): Injection site reaction (10.5%)
Common (1% to 10%): Injection site hematoma, erythema, rash, and/or pruritus
Uncommon (0.1% to 1%): Injection site hypersensitivity and/or hemorrhage[Ref]

Metabolic

Very common (10% or more): Hypoglycemia (up to 17%)[Ref]

Musculoskeletal

Very common (10% or more): Back pain (6.7%), arthralgia (6.6%)[Ref]

Other

Very common (10% or more): Influenza (5.2%)[Ref]

Respiratory

Very common (10% or more): Upper respiratory tract infection (14.2%), cough (6.9%), sinusitis (6.2%)
Common (1% to 10%): Pneumonia[Ref]

Cardiovascular

Common (1% to 10%): Atrial fibrillation
Uncommon (0.1% to 1%): Atrial flutter[Ref]

Hepatic

Common (1% to 10%): Increased ALT, gamma glutamyltransferase[Ref]

Hypersensitivity

Frequency not reported: Pruritus, rash, dyspnea[Ref]

Oncologic

Frequency not reported: Risk of Thyroid C-cell Tumors[Ref]

Medullary thyroid cancer (MTC) was diagnosed in 1 patient receiving this drug and 1 patient receiving placebo across 8 phase 3 clinical trials. Both of these patients had markedly elevated serum calcitonin levels at baseline.[Ref]

Renal

Frequency not reported: Renal impairment[Ref]

References

1. "Product Information. Tanzeum (albiglutide)." GlaxoSmithKline, Research Triangle Park, NC.

Not all side effects for albiglutide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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