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AK-Tob Side Effects

Generic name: tobramycin ophthalmic

Medically reviewed by Last updated on Dec 26, 2020.

Note: This document contains side effect information about tobramycin ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name AK-Tob.

For the Consumer

Applies to tobramycin ophthalmic: ophthalmic ointment, ophthalmic solution

Side effects requiring immediate medical attention

Along with its needed effects, tobramycin ophthalmic (the active ingredient contained in AK-Tob) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tobramycin ophthalmic:

Less common

  • Itching, redness, swelling, or other sign of eye or eyelid irritation not present before use of this medicine

Symptoms of overdose

  • Increased watering of the eyes
  • itching, redness, or swelling of the eyes or eyelids
  • painful irritation of the clear front part of the eye

Side effects not requiring immediate medical attention

Some side effects of tobramycin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Burning or stinging of the eyes

Eye ointments usually cause your vision to blur for a few minutes after application.

For Healthcare Professionals

Applies to tobramycin ophthalmic: ophthalmic ointment, ophthalmic solution


The most frequently reported side effects included localized ocular toxicity and hypersensitivity reactions.[Ref]


Common (1% to 10%): Conjunctival erythema, eye itching, lacrimation, lid itching, lid swelling, ocular discomfort, ocular hyperemia, punctate keratitis

Uncommon (0.1% to 1%): Blurred vision, conjunctival disorder, dry eye, eye discharge, eye pain, eye pruritus, eyelid disorder, eyelid edema, eyelid erythema, keratitis, lacrimation increased, visual impairment

Frequency not reported: Burning of the eyes, eye allergy, eye irritation, eyelid pruritus, stinging of the eyes[Ref]


Common (1% to 10%): Hypersensitivity reactions

Frequency not reported: Anaphylactic reaction[Ref]


Uncommon (0.1% to 1%): Dermatitis, dry skin, leukoderma, madarosis, pruritus, urticaria

Frequency not reported: Erythema multiforme, rash, Stevens-Johnson syndrome[Ref]


Frequency not reported: Increased systemic toxicity[Ref]

The risk of systemic toxicity is higher in patients receiving systemic aminoglycosides concurrently; total serum concentration monitoring should be considered in this population.[Ref]


Localized ocular toxicity included conjunctival erythema, eye itching, lacrimation, lid itching, lid swelling, ocular hyperemia, and punctate keratitis.[Ref]

Common (1% to 10%): Localized ocular toxicity

Uncommon (0.1% to 1%): Corneal abrasion, foreign body sensation in eyes[Ref]

Nervous system

Uncommon (0.1% to 1%): Headache[Ref]

More about AK-Tob (tobramycin ophthalmic)

Consumer resources

Other brands
Tobrex, Tomycine, Tobrasol

Professional resources

Related treatment guides


1. "Product Information. Tobrex (tobramycin ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

2. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.