Adapalene / benzoyl peroxide topical Side Effects
Commonly reported side effects of adapalene/benzoyl peroxide topical include: burning sensation of skin, stinging of the skin, desquamation, erythema, and xeroderma. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to adapalene / benzoyl peroxide topical: topical application gel/jelly
In addition to its needed effects, some unwanted effects may be caused by adapalene / benzoyl peroxide topical. In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking adapalene / benzoyl peroxide topical:More common:
- Dryness and peeling of the skin
- flushing or redness of the skin
- unusually warm skin
- Blistering, burning, crusting, or flaking of the skin
- burning, itching, redness, skin rash, swelling, or soreness at the application site
- scaling, severe redness, or swelling of the skin
- Skin pain
Some of the side effects that can occur with adapalene / benzoyl peroxide topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Incidence not known:
- Burning, dry, or itching eyes
- change in the color of the treated skin
- discharge or excessive tearing
- redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
- skin rash, encrusted, scaly, and oozing
- swelling of the face
For Healthcare Professionals
Applies to adapalene / benzoyl peroxide topical: topical gel
Dermatologic reactions during a clinical study included erythema, scaling, dryness and stinging/burning. These reactions occurred in 27% to 41% of study participants and were mostly mild to moderate, with only 1% to 3% experiencing severe reactions. Analysis of study data during a 12-week period showed that side effects such as erythema, scaling, dryness, and stinging/burning peaked during the first week of therapy and decreased thereafter.[Ref]
Dermatologic side effects have included dry skin (7%), contact dermatitis (3%), application site burning (2%), application site irritation (1%), and skin irritation (1%).[Ref]
General side effects reported postmarketing have included eyelid edema, sunburn, blister, pain of skin, pruritus, swelling face, conjunctivitis, skin discoloration, rash, eczema, and allergic contact dermatitis.
1. "Product Information. Epiduo (adapalene-benzoyl peroxide topical)." Galderma Laboratories Inc, Cranbury, NJ.
Not all side effects for adapalene / benzoyl peroxide topical may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
More about adapalene/benzoyl peroxide topical
- Adapalene and benzoyl peroxide gel
- Adapalene and benzoyl peroxide topical
- Adapalene and benzoyl peroxide Topical application (Advanced Reading)
Related treatment guides
Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.