Abrocitinib Side Effects
Medically reviewed by Drugs.com. Last updated on Nov 11, 2024.
Applies to abrocitinib: oral tablet.
Important warnings
This medicine can cause some serious health issues
Common side effects of abrocitinib
Some side effects of abrocitinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- stuffy nose
Less common side effects
- bladder pain
- blemishes on the skin
- difficult, burning, or painful urination
- frequent urge to urinate
- lower back or side pain
- pimple
Serious side effects of abrocitinib
Along with its needed effects, abrocitinib may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking abrocitinib:
Less common side effects
- black, tarry stools
- bleeding gums
- blood in the urine or stools
- burning or stinging of skin
- chills
- cough
- diarrhea
- fever
- general feeling of discomfort or illness
- headache
- joint pain
- loss of appetite
- muscle aches and pains
- nausea
- painful blisters on the trunk of the body
- painful cold sores or blisters on the lips, nose, eyes, or genitals
- pinpoint red spots on the skin
- runny nose
- shivering
- sore throat
- stomach pain
- sweating
- trouble sleeping
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting
Rare side effects
- blistering, burning, crusting, dryness, or flaking of the skin
- blurred vision
- dizziness
- itching, scaling, severe redness, soreness, or swelling of the skin
- nervousness
- pounding in the ears
- red rash with watery, yellow-colored, or pus filled blisters
- slow or fast heartbeat
- thick yellow to honey-colored crusts
Incidence not known
- chest pain or tightness
- persistent non-healing sore
- pink growth
- reddish patch or irritated area
- seeing flashes or sparks of light
- seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
- white, yellow or waxy scar-like area
- shiny bump
For healthcare professionals
Applies to abrocitinib: oral tablet.
General adverse events
The most common adverse reactions were headache, dizziness, fatigue, nausea, vomiting, oropharyngeal pain, upper abdominal pain, abdominal discomfort, nasopharyngitis, gastroenteritis, impetigo, influenza, hypertension, acne, contact dermatitis, herpes simplex infection, herpes zoster infection, increased blood creatine phosphokinase, urinary tract infection, and thrombocytopenia.[Ref]
Cardiovascular
- Common (1% to 10%): Hypertension
- Uncommon (0.1% to 1%): Pulmonary embolism, deep venous thrombosis, major adverse cardiovascular events[Ref]
Other
- Very common (10% or more): Overall infection (up to 26%)
- Common (1% to 10%): Fatigue, serious infection, herpes simplex, herpes zoster, influenza, creatinine phosphokinase elevations[Ref]
Herpes simplex also included oral herpes, ophthalmic herpes, herpes dermatitis, genital herpes.[Ref]
Oncologic
- Uncommon (0.1% to 1%): Malignancies[Ref]
Hematologic
- Common (1% to 10%): Lymphopenia
- Uncommon (0.1% to 1%): Thrombocytopenia[Ref]
Gastrointestinal
- Very common (10% or more): Nausea (up to 14.5%)
- Common (1% to 10%): Abdominal discomfort, abdominal pain upper, gastroenteritis, vomiting[Ref]
Dermatologic
- Common (1% to 10%): Acne, impetigo, contact dermatitis[Ref]
Genitourinary
- Common (1% to 10%): Urinary tract infections[Ref]
Ocular
- Uncommon (0.1% to 1%): Retinal detachment[Ref]
Metabolic
- Common (1% to 10%): Lipid elevations[Ref]
Respiratory
- Very common (10% or more): Nasopharyngitis (up to 13%)
- Common (1% to 10%): Oropharyngeal pain
- Uncommon (0.1% to 1%): Pneumonia[Ref]
Nervous system
- Common (1% to 10%): Headache, dizziness[Ref]
References
1. (2022) "Product Information. Cibinqo (abrocitinib)." Pfizer U.S. Pharmaceuticals Group
Frequently asked questions
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Further information
Abrocitinib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.