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Medically reviewed by Last updated on Sep 16, 2020.


(loo li KON a zole)

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Cream, External:

Luzu: 1% (60 g) [contains benzyl alcohol, methylparaben, propylene glycol]

Generic: 1% (60 g)

Brand Names: U.S.

  • Luzu

Pharmacologic Category

  • Antifungal Agent, Topical


Azole antifungal that appears to inhibit ergosterol synthesis by inhibiting the enzyme lanosterol demethylase, resulting in decreased amounts of ergosterol and a corresponding accumulation of lanosterol.


Small amounts may be absorbed following topical application

Protein Binding

>99%; to plasma proteins

Use: Labeled Indications

Fungal infections: Topical treatment of interdigital tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum and Epidermophyton floccosum


There are no contraindications listed in the manufacturer's labeling.

Dosing: Adult

Fungal infections: Topical:

Tinea pedis: Apply to affected area and ~1 inch of immediate surrounding area(s) once daily for 2 weeks

Tinea cruris or tinea corporis: Apply to affected area and ~1 inch of immediate surrounding area(s) once daily for 1 week

Dosing: Geriatric

Refer to adult dosing.

Dosing: Pediatric

Fungal infections: Topical:

Tinea pedis or tinea cruris: Children ≥12 years and Adolescents: Refer to adult dosing

Tinea corporis: Children ≥2 years and Adolescents: Refer to adult dosing


For topical use only. Not for ophthalmic, oral, or intravaginal use. Apply to affected area and ~1 inch of immediate surrounding area(s). Wash hands following application.


Store at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).

Drug Interactions

CloBAZam: CYP2C19 Inhibitors (Weak) may increase serum concentrations of the active metabolite(s) of CloBAZam. CYP2C19 Inhibitors (Weak) may increase the serum concentration of CloBAZam. Monitor therapy

Fosphenytoin-Phenytoin: CYP2C19 Inhibitors (Weak) may increase the serum concentration of Fosphenytoin-Phenytoin. Monitor therapy

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

<1%, postmarketing, and/or case reports: Application site reaction, cellulitis, contact dermatitis



• Appropriate use: For topical use only; not for oral, ophthalmic, or intravaginal use.

Pregnancy Considerations

Adverse events were observed in some animal reproduction studies. Small amounts of luliconazole are absorbed systemically.

Patient Education

What is this drug used for?

• It is used to treat fungal infections of the skin.

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Severe skin irritation

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.