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Teniposide

Generic name: teniposide (ten IP oh side)
Brand name: Vumon
Dosage forms: intravenous solution (10 mg/mL)
Drug class: Mitotic inhibitors

Medically reviewed by Drugs.com on Jun 23, 2021. Written by Cerner Multum.

What is teniposide?

Teniposide is used in combination chemotherapy to treat childhood acute lymphoblastic leukemia (a type of blood cancer).

Teniposide is given after other treatments did not work or stopped working.

Teniposide may also be used for purposes not listed in this medication guide.

Warnings

Teniposide can cause severe allergic reactions and may increase your risk of bleeding or infection. You may be given other medications to help prevent certain side effects or an allergic reaction.

Before taking this medicine

You should not be treated with teniposide if you are allergic to teniposide or to polyoxyl 35 castor oil.

Tell your doctor if you have ever had:

  • Down Syndrome;

  • bone marrow suppression; or

  • liver or kidney disease.

Using teniposide may increase your risk of developing other cancers. Ask your doctor about this risk.

May cause birth defects. Do not use if you are pregnant. Use birth control while using teniposide and tell your doctor if you become pregnant.

This medication can decrease sperm count and may affect fertility in men (your ability to have children).

Do not breastfeed.

How is teniposide given?

Teniposide is injected into a vein by a healthcare provider.

This medicine is injected slowly over 30 to 60 minutes.

You may be given other medications to help prevent serious side effects or an allergic reaction.

Tell your caregivers if you feel any burning or pain when teniposide is injected.

You will be watched closely for at least 60 minutes to make sure you do not have an allergic reaction.

If this medicine gets in your eyes, mouth, nose, or on your skin, immediately wash the skin with soap and water or rinse your eyes with water.

Teniposide can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your teniposide injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving teniposide?

Avoid activities that may increase your risk of bleeding or injury. Use extra care while shaving or brushing your teeth.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Teniposide side effects

Get emergency medical help if you have signs of an allergic reaction: hives, skin rash, warmth or tingling; fever, chills, feeling light-headed; wheezing, chest tightness, fast heartbeats, trouble breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during or shortly after the injection. Tell your care provider if you feel dizzy, nauseated, light-headed, feverish, chilled, itchy, anxious, or have chest tightness, trouble breathing, or warmth in your face.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • severe ongoing vomiting or diarrhea;

  • sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;

  • pain, burning, irritation, or skin changes where the injection was given;

  • low blood cell counts--fever, chills, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;

  • signs of too much acid in your blood--irregular heartbeats, feeling tired, loss of appetite, trouble thinking, feeling short of breath; or

  • symptoms of sepsis--confusion, severe drowsiness, fast heartbeats, rapid breathing, feeling very ill.

Common side effects may include:

  • nausea, vomiting, diarrhea;

  • mouth sores;

  • hair loss; or

  • infections, low blood cell counts.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Teniposide dosing information

Usual Adult Dose for Acute Lymphoblastic Leukemia:

Patients failing induction therapy with a cytarabine-containing regimen:
165 mg/m2 IV over at least 30 to 60 minutes and 300 mg/m2 cytarabine IV twice weekly for 8 to 9 doses

Patients refractory to vincristine/prednisone-containing regimens:
250 mg/m2 IV over at least 30 to 60 minutes and 1.5 mg/m2 vincristine IV weekly for 4 to 8 weeks with 40 mg/m2 prednisone orally for 28 days

Use: For induction therapy in patients with refractory childhood acute lymphoblastic leukemia (ALL) in combination with other approved anticancer agents

Usual Pediatric Dose for Acute Lymphoblastic Leukemia:

Patients failing induction therapy with a cytarabine-containing regimen:
14 days and older:
165 mg/m2 IV over at least 30 to 60 minutes and 300 mg/m2 cytarabine IV twice weekly for 8 to 9 doses

Patients refractory to vincristine/prednisone-containing regimens:
14 days and older:
250 mg/m2 IV over at least 30 to 60 minutes and 1.5 mg/m2 vincristine IV weekly for 4 to 8 weeks with 40 mg/m2 prednisone orally for 28 days

Use: For induction therapy in patients with refractory childhood acute lymphoblastic leukemia (ALL) in combination with other approved anticancer agents

What other drugs will affect teniposide?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect teniposide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Does Teniposide interact with my other drugs?

Enter other medications to view a detailed report.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.