Sandostatin LAR Depot (injection)
Generic Name: octreotide (injection) (ok TREE oh tide)
Brand Name: SandoSTATIN, SandoSTATIN LAR Depot
Medically reviewed on January 8, 2018
What is Sandostatin LAR Depot?
Sandostatin LAR Depot is a man-made protein that is similar to a hormone in the body called somatostatin. This medicine lowers many substances in the body such as insulin and glucagon (involved in regulating blood sugar), growth hormone, and chemicals that affect digestion.
Sandostatin LAR Depot is used to treat acromegaly. This medicine is also used to reduce flushing episodes and watery diarrhea caused by cancerous tumors (carcinoid syndrome) or tumors called vasoactive intestinal peptide tumors (VIP adenomas).
Sandostatin LAR Depot may also be used for purposes not listed in this medication guide.
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
Before taking this medicine
You should not use Sandostatin LAR Depot if you are allergic to it.
To make sure you can safely use Sandostatin LAR Depot, tell your doctor if you have any of these other conditions:
heart disease, high blood pressure, or heart rhythm disorder;
liver disease; or
kidney disease (or if you are on dialysis).
Sandostatin LAR Depot is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Using Sandostatin LAR Depot can affect certain hormones that may make it easier for you to get pregnant, even if you were unable to get pregnant before. Talk to your doctor about using birth control to avoid unwanted pregnancy.
It is not known whether octreotide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I use Sandostatin LAR Depot?
Follow all directions on your prescription label. Do not use Sandostatin LAR Depot in larger or smaller amounts or for longer than recommended.
Sandostatin LAR Depot is injected under the skin, or into a vein through an IV. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine. Be sure to follow the instructions for the exact type of octreotide your doctor has prescribed for you.
Store Sandostatin LAR Depot in the original carton in the refrigerator. Protect from light.
Sandostatin LAR Depot should be at room temperature when you inject it. Take the medicine out of the refrigerator 30 to 60 minutes before preparing your dose. Do not heat the medicine. After mixing your dose, give the injection right away. Do not save it for later use.
Prepare your dose only when you are ready to give yourself an injection. Do not use Sandostatin LAR Depot if it has changed colors or has particles in it. Call your pharmacist for new medication.
Your care provider will show you the best places on your body to inject Sandostatin LAR Depot. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
While using Sandostatin LAR Depot, you may need frequent medical tests.
Each single-use ampul is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
If refrigeration is not available, you may store an unopened single-use ampul or multi-dose vial at room temperature for up to 14 days. Keep away from moisture and heat.
Throw away any medicine left in the multi-use vial after 14 days of use. Then start a new vial.
What happens if I miss a dose?
Call your doctor for instructions if you miss a dose of Sandostatin LAR Depot.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe upper stomach pain, diarrhea, weight loss, warmth or tingling, numbness or cold feeling, unexplained muscle pain, weakness, weak pulse, fainting, or slow breathing (breathing may stop).
What should I avoid while using Sandostatin LAR Depot?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Sandostatin LAR Depot side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe stomach pain or tenderness, severe constipation;
slow or uneven heartbeats;
high blood sugar--increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss;
underactive thyroid--extreme tired feeling, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cold temperatures, weight gain.
Common side effects may include:
headache, dizziness; or
pain when injecting the medicine.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Sandostatin LAR Depot?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Sandostatin LAR Depot, especially:
insulin or oral diabetes medicine;
a diuretic or "water pill"; or
medicine for heart disease or high blood pressure.
This list is not complete. Other drugs may interact with octreotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Copyright 1996-2018 Cerner Multum, Inc. Version: 5.01.
More about Sandostatin LAR Depot (octreotide)
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- Drug class: somatostatin and somatostatin analogs