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Onxol

Generic Name: paclitaxel (PAK li TAK sel)
Brand Name: Onxol

Medically reviewed on August 6, 2018

The Onxol brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.

What is Onxol?

See also: Kisqali

Onxol is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Onxol is used to treat breast cancer, ovarian cancer, and lung cancer. It is also used to treat AIDS-related Kaposi's sarcoma.

Onxol may also be used for purposes not listed in this medication guide.

Important Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Onxol can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Before taking this medicine

You should not receive this medication if you are allergic to Onxol, or to other medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). This includes cyclosporine and teniposide.

To make sure Onxol is safe for you, tell your doctor if you have:

Do not receive Onxol if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether paclitaxel passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using paclitaxel.

How is Onxol given?

Onxol is injected into a vein through an IV. A healthcare provider will give you this injection. You may be given other medications to prevent an allergic reaction while you are receiving this medicine.

Onxol is usually given once every 3 weeks. Follow your doctor's dosing instructions very carefully.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving Onxol.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Onxol is injected.

Onxol can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Onxol.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Onxol?

Drinking alcohol can increase certain side effects of paclitaxel.

Onxol can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Do not receive a "live" vaccine while using Onxol. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Onxol side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  • pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;

  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

  • flushing (warmth, redness, or tingly feeling);

  • slow heart rate, feeling like you might pass out;

  • seizure (convulsions);

  • chest pain, dry cough, wheezing, feeling short of breath;

  • numbness, tingling, or burning pain in your hands or feet;

  • jaundice (yellowing of the skin or eyes); or

  • severe redness or swelling, severe irritation, a hard lump, or skin changes where the injection was given.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Onxol?

Many drugs can interact with Onxol. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with this medicine, especially:

This list is not complete and many other drugs can interact with Onxol. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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