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Paclitaxel Pregnancy and Breastfeeding Warnings

Paclitaxel is also known as: Onxol, Taxol

Paclitaxel Pregnancy Warnings

Animal studies have resulted in abortions, decreased corpora lutea, a decrease in implantations and live fetuses, and increased resorptions and embryo-fetal deaths.

Paclitaxel has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of low fertility and fetotoxicity in rats and evidence of maternal, embryo and fetotoxicity in rabbits. There are no controlled data in human pregnancy. If this drug is used during pregnancy, or if the patient becomes pregnant while receiving this drug, the patient should be apprised of the potential hazard to the fetus or potential risk for loss of the pregnancy. Women of childbearing potential should be advised to avoid becoming pregnant during therapy.

See references

Paclitaxel Breastfeeding Warnings

There are no data on the excretion of paclitaxel into human milk. Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants, mothers should discontinue nursing prior to administration of paclitaxel.

Animal studies have revealed that intravenous administration of carbon-14 labeled paclitaxel on days 9 to 10 postpartum, concentrations of radioactivity in milk were higher than in plasma and declined in parallel with the plasma concentrations.

See references

References for pregnancy information

  1. "Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb, Princeton, NJ.

References for breastfeeding information

  1. "Product Information. Abraxane (paclitaxel protein-bound)." American Pharmaceutical Partners, Schaumberg, IL.
  2. "Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb, Princeton, NJ.

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