Lynozyfic

Generic name: linvoseltamab [ LIN-voe-SEL-ta-mab ]
Drug class: Bispecific T-cell engagers (BiTE)

Medically reviewed by Drugs.com on Aug 5, 2025. Written by Cerner Multum.

What is linvoseltamab?

Linvoseltamab is used to treat adults with multiple myeloma who have received at least 4 treatment regimens and their cancer has returned or did not respond to a previous treatment.

Linvoseltamab is available only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.

Linvoseltamab may also be used for purposes not listed in this medication guide.

Linvoseltamab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Tell your medical caregivers if you have signs of cytokine release syndrome (CRS), a serious side effect: fever, chills, trouble breathing, confusion, severe vomiting or diarrhea, fast or irregular heartbeats, feeling light-headed or very tired.

Some side effects may occur during the injection. Tell your medical caregiver if you feel dizzy, nauseated, light-headed, itchy, sweaty, or have a headache, chest tightness, back pain, trouble breathing, or swelling in your face.

Lynozyfic may cause serious side effects. Call your doctor at once if you have:

• neurological problems--headache, jerking muscle movements, rigid muscles, feeling restless, numbness and tingling, confusion, problems speaking, muscle spasms, tremors, double vision, changes in handwriting, problems walking, muscle weakness in body or face, hearing loss, burning, throbbing, or stabbing pain;

• signs of infection or low white blood cell counts--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding, shortness of breath, chest pain, painful urination, mouth sores, skin sores, cough; or

• liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Lynozyfic may include:

• muscle or bone pain;

• cough with or without mucus;

• nausea, diarrhea;

• tiredness or weakness;

• headache;

• cold symptoms such as stuffy nose, sneezing, sore throat;

• fever, chills, chest pain, feeling short of breath; or

• abnormal blood tests (low white and red blood cell counts).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Related/similar drugs

Warnings

Call your doctor if you have symptoms of neurological problems such as headache, agitation, tiredness, confusion, hallucinations, problems with thinking or memory, unusual muscle problems or pain, numbness and tingling, seizures, walking difficulties, handwriting or speech changes.

Tell your medical caregivers if you have symptoms of a serious side effect, such as fever, chills, trouble breathing, vomiting, or severe tiredness.

Before taking this medicine

Tell your doctor if you have or have ever had:

• low white blood cell (WBC) counts;

• an active or recent infection; or

• abnormal liver function tests.

May harm an unborn baby. Do not use if you are pregnant. You may need a pregnancy test to make sure you are not pregnant. Use effective birth control while using linvoseltamab and for at least 3 months after your last dose. Tell your doctor if you become pregnant.

Do not breastfeed while using this medicine, and for at least 3 months after your last dose.

How is linvoseltamab given?

Follow all directions on your prescription label and read all medication guides or instruction sheets.

Read the Patient Wallet Card about serious side effects and learn what symptoms to watch for. Keep the card with you at all times.

Linvoseltamab is given as an infusion into a vein by a healthcare provider.

You will need to stay in the hospital for 24 hours after some doses of linvoseltamab. Talk with your doctor if you have any questions.

Your doctor will determine the right treatment schedule for you.

You may be given other medications to help prevent serious side effects or allergic reaction. Keep using these medicines for as long as your doctor has prescribed. Your doctor will monitor you for these side effects.

You will need frequent medical tests and your cancer treatments may be delayed or discontinued based on the results.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your linvoseltamab injection.

What happens if I overdose?

In a medical setting an overdose would be treated quickly.

What should I avoid while receiving linvoseltamab?

Avoid driving or hazardous activity for 48 hours after receiving certain doses of this medicine or until neurological symptoms go away. Your reactions could be impaired.

What other drugs will affect linvoseltamab?

Other drugs may affect linvoseltamab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Biological Products Related to Lynozyfic

Find detailed information on biosimilars for this medication.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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