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Glycopyrrolate topical (glycopyrronium cloth)

Generic name: glycopyrrolate topical (glycopyrronium cloth) [ GLYE-koe-PIR-oh-late-TOP-ik-al ]
Brand name: Qbrexza
Dosage form: topical pad (2.4%)
Drug class: Miscellaneous topical agents

Medically reviewed by on Nov 7, 2022. Written by Cerner Multum.

What is glycopyrrolate topical?

Glycopyrrolate topical (glycopyrronium cloth) is used on underarm skin to treat excessive sweating (hyperhidrosis) in adults and children who are at least 9 years old.

Glycopyrrolate topical may also be used for purposes not listed in this medication guide.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use glycopyrrolate topical if you have:

Tell your doctor if you have ever had:

  • bladder obstruction or other urination problems,

  • kidney disease; or

  • an enlarged prostate.

Tell your doctor if you are pregnant or breast-feeding.

How should I use glycopyrrolate topical?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Apply only to clean, dry underarm skin. Do not use on open wounds or broken skin.

Do not cover treated skin with a bandage or with plastic.

Use a single glycopyrrolate topical cloth on both underarms once every 24 hours. Then throw the cloth away.

Wash your hands after handling a glycopyrrolate topical cloth. Any medicine left on your hands could cause blurred vision if you later touch your eyes.

Store at room temperature away from moisture and heat.

Keep each cloth in the sealed pouch until it is time for you to apply the medicine.

Glycopyrrolate cloths are flammable. Do not use near high heat or open flame.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two cloths at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include dry mouth, constipation, urination problems, feeling warm or tingly, or fast heartbeats.

What should I avoid while using glycopyrrolate topical?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Glycopyrrolate topical decreases sweating, and you may be more prone to heat stroke.

glycopyrrolate topical may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Avoid getting this medicine in your eyes.

Glycopyrrolate topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

This medicine may cause serious side effects. Stop using this medicine and call your doctor at once if you have:

  • little or no sweating in hot conditions (such as during exercise or while exposed to high heat);

  • fever, hot or red skin;

  • trouble emptying your bladder (or you have a weak stream of urine);

  • painful or difficult urination;

  • increased urination;

  • rapid or shallow breathing;

  • weak and rapid pulse; or

  • a light-headed feeling, like you might pass out.

Common side effects of glycopyrrolate topical may include:

  • burning, stinging, or redness of your underarms;

  • urination problems;

  • blurred vision, dilated pupils (your eyes may be more sensitive to light);

  • headache;

  • dry nose, sore throat;

  • dry eyes; or

  • constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Glycopyrrolate topical dosing information

Usual Adult Dose for Hyperhidrosis:

Use one cloth to wipe the entire underarm once, use the same cloth to wipe the other entire underarm once
Maximum frequency: Once every 24 hours

Usual Pediatric Dose for Hyperhidrosis:

9 years and older:
Use one cloth to wipe the entire underarm once, use the same cloth to wipe the other entire underarm once
Maximum frequency: Once every 24 hours

What other drugs will affect glycopyrrolate topical?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect glycopyrrolate topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Frequently asked questions

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.