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Drysol (topical)

Generic Name: aluminum chloride hexahydrate (topical) (al LOO min um KLOR ide HEX a HYE drayt TOP ik al)
Brand Name: Drysol, Hypercare, Xerac AC

Medically reviewed by on Sep 11, 2019 – Written by Cerner Multum

What is Drysol?

Drysol is an antiperspirant that works by affecting the cells that produce sweat.

Drysol (for the skin) is used to treat excessive sweating, also called hyperhidrosis.

Drysol may also be used for purposes not listed in this medication guide.

Important Information

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Drysol if you are allergic to it.

To make sure Drysol is safe for you, tell your doctor if you are taking disulfiram (Antabuse).

FDA pregnancy category C. It is not known whether Drysol will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Drysol.

It is not known whether aluminum chloride hexahydrate passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I use Drysol?

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. For best results, apply the medicine only at bedtime when you are less likely to sweat. You will need to leave the medicine on your skin for 6 to 8 hours.

This medicine comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Wash and completely dry the skin before applying Drysol. You may need to use a hair dryer to thoroughly dry the skin.

Use the applicator provided with your medicine. If your medicine does not include an applicator, use a cotton ball to apply the medicine. Apply the medicine evenly and allow it to dry into a thin film. Use a hair dryer on a cool setting to dry the skin if needed.

After use on the underarms: Wear a tee-shirt to keep the medicine from rubbing off onto your bed linens.

After use on the hands or feet: Wrap your hands or feet in plastic wrap and cover them with cotton gloves or socks. Do not tape the plastic onto your skin. Leave the gloves or socks on while you sleep.

After use on the scalp: Wear a plastic shower cap to bed to keep the medicine from rubbing off onto your bed linens.

When you awake in the morning, remove the clothing or plastic covering from the treated skin areas. Wash or shampoo the skin thoroughly, and towel dry. Throw away the plastic wrap do not reuse it for additional applications. You may rinse out the plastic shower cap with water and allow it to dry completely before using again.

Keep using the medicine for another 2 or 3 nights until you notice reduced sweating. After that, you may need to use Drysol once or twice per week to control your condition.

Store at room temperature away from heat or open flame. Drysol contains alcohol and is flammable. This medicine will evaporate quickly when exposed to air. Keep the bottle tightly closed when you are not using the medicine.

What happens if I miss a dose?

Skip the missed dose and use the medicine the following night. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of Drysol is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using aluminum chloride hexahydrate?

Do not apply any other deodorants or antiperspirants while you are using Drysol.

Drysol contains alcohol, which can cause slight burning or stinging when you apply the medicine. Do not use on irritated or broken skin, or skin that has recently been shaved.

Avoid getting Drysol in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water.

Drysol can stain certain types of fabric or metals that it comes in contact with. Avoid getting the medicine on surfaces you do not want to stain.

Do not share this medicine with another person, even if they have the same symptoms you have.

Drysol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; dizziness; tight feeling in your chest, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe burning, redness, or swelling of treated skin.

Common side effects may include:

  • itching or mild burning of treated skin; or

  • tingling or prickly feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Drysol?

It is not likely that other drugs you take orally or inject will have an effect on topically applied Drysol. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Drysol (aluminum chloride hexahydrate topical)

Consumer resources

Other brands: Xerac AC, Hypercare

Professional resources

Related treatment guides