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Aluminum Chloride (Topical) (Monograph)

Brand names: Certain Dri, Drysol, Hypercare, Xerac AC
Drug class: Astringents
VA class: DE450
Chemical name: Aluminum chloride, hexahydrate
Molecular formula: AlCl3•6H2O
CAS number: 7784-13-6, 7446-70-0

Medically reviewed by on Feb 20, 2024. Written by ASHP.



Uses for Aluminum Chloride (Topical)


Topical treatment of hyperhidrosis.

Hyperhidrosis (excessive sweating) may be primary (physiologic, idiopathic, essential; possibly hereditary) or secondary (associated with an underlying condition). Secondary hyperhidrosis is associated with neurologic, endocrinologic, metabolic, or other such disorders; febrile illness; malignancy; or drugs.

Hyperhidrosis is classified as focal or generalized. Focal hyperhidrosis most commonly affects the palms and soles (palmar-plantar hyperhidrosis) and underarms (axillary hyperhidrosis), and least commonly affects the face (craniofacial hyperhidrosis). Generalized hyperhidrosis involves the entire body and usually is associated with an underlying condition.

Generally considered first-line therapy for mild or moderate primary focal hyperhidrosis, including axillary and palmar-plantar hyperhidrosis. An adequate trial of topical aluminum chloride usually is recommended before other therapeutic options (e.g., botulinum toxin injections, iontophoresis, local excision, liposuction, sympathectomy) considered. In severe cases of axillary, palmar, or plantar hyperhidrosis, some clinicians state that aluminum chloride hexahydrate, botulinum toxin injections, or iontophoresis are considered first-line therapy.

One of several options for treatment of craniofacial hyperhidrosis.

Self-medication (Certain Dri, OTC use) for axillary hyperhidrosis only.

Aluminum Chloride (Topical) Dosage and Administration


Topical Administration

Preparations are for external use only.

Apply topically to the skin as a solution or as an antiperspirant stick.

Avoid contact with eyes. If contact occurs, wash affected eye(s) thoroughly with water.

Apply to dry, intact skin only; do not apply to any irritated, broken, or recently shaven areas. May use a hairdryer on warm setting to dry the skin.

Do not apply other deodorants or antiperspirants to treatment area.

For optimum effect, apply at bedtime when sweat glands are least active.

Apply solution using fingers, moistened cotton ball, or applicator (Dab-O-Matic) supplied by manufacturer. If using the Dab-O-Matic applicator, remove and discard protective cap prior to use. Push applicator into bottle and twist white cap to secure in place.

Consult individual manufacturer’s prescribing or patient information for complete instructions regarding proper drug application and removal.



Axillary, Palmar, Plantar, or Craniofacial Hyperhidrosis

Apply solution to completely dry affected area (e.g., underarms, palms, soles, scalp) once daily at bedtime.

To minimize irritation when using the solution, let alcohol evaporate (may use a hairdryer on cold setting when administered under arms); a thin film of drug should remain on skin.

To prevent drug from rubbing off, cover treated area with a T-shirt for axillary application; use a plastic shower cap for scalp application or plastic wrap and overlying gloves or socks for palmar or plantar application, respectively. Do not use adhesive tape. Some clinicians state that occlusion is not necessary and may increase risk of skin irritation. (See Dermatologic Effects under Cautions.)

After 6–8 hours (usually the following morning), remove garments and/or plastic wrap; to prevent irritation, wash treatment area(s) thoroughly with soap and water or shampoo. Some clinicians also suggest topical application of sodium bicarbonate. Dry with towel.

Repeat applications for ≥2 consecutive nights until desired effect (lack of sweating) achieved. Thereafter, may apply additional treatments once or twice weekly as needed.

Self-medication for Axillary Hyperhidrosis

Apply sparingly (i.e., a few strokes) to affected areas under each arm. Dry skin completely prior to application.

Allow solution to dry following application.

May repeat treatment until desired effect achieved. Thereafter, apply every other day or as needed.

Cautions for Aluminum Chloride (Topical)





Self-medication: Apply Certain Dri to underarms only. (For further information on warnings and precautions associated with administration of aluminum chloride hexahydrate (Drysol, Xerac AC, and Hypercare) and aluminum chloride [Certain Dri], see Topical Administration under Dosage and Administration.)


Aluminum chloride solutions are flammable; do not use near an open flame.

Sensitivity Reactions

Dermatologic Effects

Possible local irritation (e.g., burning, stinging, itching, tingling); usually resolves with temporary discontinuance of drug. Because risk of skin sensitivity increases with higher concentrations, some patients may benefit from an initial trial with reduced concentrations (10–12%) of aluminum chloride hexahydrate.

To minimize skin irritation, follow specific instructions provided by each manufacturer on proper drug application and removal. Ensure that skin is completely dry prior to and following drug application. (See Topical Administration under Dosage and Administration.)

If rash or skin reaction develops during therapy, discontinue use and consult a clinician. Topical sodium bicarbonate or a low-dose corticosteroid cream (e.g., 1% hydrocortisone) may be used to limit or treat irritation. Other measures include decreasing concentration or frequency of applications. If persistent skin irritation occurs, refer patient to a dermatologist.

General Precautions

Fabric or Metal Stains

May be harmful to certain fabrics (e.g., cotton) or metals. Allow skin to dry completely following application and thoroughly wash off any residual drug after 6–8 hours of treatment to avoid damage to clothing.

Specific Populations


The manufacturer of Drysol and Xerac AC states that there is no pregnancy category for these drugs; however, they recommend that the drug not be used in pregnant women.

Pediatric Use

Keep preparations out of reach of children.

Infants (especially preterm infants) and children may be at greater risk of aluminum exposure because of immature renal function.

Renal Impairment

Possible increased exposure to any systemically absorbed aluminum in patients with renal impairment; patients with renal impairment should consult a clinician before use. (See Bioavailability and Special Populations under Pharmacokinetics.)

Common Adverse Effects

Local skin irritation (burning, stinging, itching, tingling).

Aluminum Chloride (Topical) Pharmacokinetics



One manufacturer states that drug is not absorbed; however, some clinicians state that minimal systemic absorption may occur when applied topically.


Following topical application of aluminum chloride hexahydrate 20% solution to the palms, reduced sweating occurs within 48 hours.


Following topical application of aluminum chloride hexahydrate 20% to the palms, effects of reduced sweating diminish or disappear within 48 hours after discontinuance of therapy.


Elimination Route

Absorbed aluminum is eliminated principally by the kidneys.

Special Populations

Renal impairment: Possible decreased clearance and increased exposure to any absorbed aluminum.





15–30°C, in tightly closed container when not in use (to prevent evaporation).

Keep away from open flames.


Advice to Patients


Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Aluminum Chloride


Dosage Forms


Brand Names





Certain Dri

DSE Healthcare Solutions

Aluminum Chloride Hexahydrate


Dosage Forms


Brand Names





Xerac AC (with anhydrous ethyl alcohol 96%)

Person and Covey


Drysol (with anhydrous ethyl alcohol 93%)

Person and Covey



AHFS DI Essentials™. © Copyright 2024, Selected Revisions March 1, 2009. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

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