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Generic Name: atropine and pralidoxime (AT roe peen and PRAL i DOX eem)
Brand Name: ATNAA, DuoDote

Medically reviewed by on Apr 9, 2018 – Written by Cerner Multum

What is DuoDote?

Atropine blocks the action of a certain chemical that may reach high levels in the body after a poisoning. Atropine also stimulates the heart and reduces the secretions of the nose, mouth, and lungs to improve breathing.

Pralidoxime reverses muscle weakness or paralysis caused by a poison or nerve agent.

DuoDote is a combination medicine used as an antidote to treat poisoning by a pesticide (insect spray) or a chemical that interferes with the central nervous system, such as nerve gas.

DuoDote is not effective as an antidote for all types of pesticide poisonings. You may need medications or additional treatments.

DuoDote may also be used for purposes not listed in this medication guide.

Important Information

In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received this medicine.

Before taking this medicine

If possible, before you receive DuoDote, tell your doctor if you have ever had:

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received DuoDote.

How is DuoDote given?

DuoDote is injected into a muscle in your upper thigh. A healthcare provider will give you this injection.

DuoDote is usually given as soon as possible after the onset of poisoning symptoms. If you still have symptoms after 10 to 15 minutes, you will receive 2 more injections.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely.

You may be watched for up to 72 hours to make sure the medicine has been effective and you no longer have any effects of the poison.

What happens if I miss a dose?

Since DuoDote is used when needed, it does not have a daily dosing schedule.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Overdose may occur if you receive DuoDote but you have not actually been exposed to the specific poisons this medication is designed to treat. Symptoms may include vision problems, feeling unsteady, loss of balance or coordination, trouble concentrating, fast heart rate, confusion, hallucinations (seeing or hearing things), decreased sweating, hot and dry skin, fainting, weak or shallow breathing, or breathing that stops.

What should I avoid after receiving DuoDote?

Avoid becoming overheated or dehydrated during exercise and in hot weather. Atropine can decrease sweating and you may be more prone to heat stroke for a short time after receiving this medication.

DuoDote side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.

Tell your caregivers right away if you have:

  • pounding heartbeats or fluttering in your chest;

  • chest pain spreading to your jaw or shoulder;

  • trouble swallowing;

  • painful or difficult urination;

  • little or no urination;

  • unusual changes in mood or behavior; or

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights.

Side effects may be more likely in older adults.

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect DuoDote?

Other drugs may affect DuoDote, including prescription and over-the-counter medicines, vitamins, and herbal products. If possible, before you receive DuoDote, tell your doctor about all your current medicines.

Further information

  • Your doctor can provide more information about DuoDote.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about DuoDote (atropine / pralidoxime)

Consumer resources

Other brands: ATNAA

Professional resources

Related treatment guides