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DuoDote Side Effects

Generic name: atropine / pralidoxime

Note: This document contains side effect information about atropine / pralidoxime. Some of the dosage forms listed on this page may not apply to the brand name DuoDote.

For the Consumer

Applies to atropine/pralidoxime: intramuscular solution

Warning

In an emergency, you may not be able to tell caregivers about your health conditions. Make sure any doctor caring for you afterward knows you received this medicine.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some of the side effects of atropine and pralidoxime may be similar to the symptoms of poisoning. Your caregivers will watch you closely to determine whether your body is responding well to the medication, or if you are having any serious side effects.

Tell your caregivers right away if you have:

  • pounding heartbeats or fluttering in your chest;

  • chest pain spreading to your jaw or shoulder;

  • trouble swallowing;

  • painful or difficult urination;

  • little or no urination;

  • unusual changes in mood or behavior; or

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights.

Side effects may be more likely in older adults.

Common side effects may include:

  • trouble breathing;

  • dry mouth;

  • dry eyes, vision changes, increased sensitivity to light;

  • nausea, vomiting;

  • fast heartbeats, increased blood pressure;

  • behavior changes, feeling excited or confused;

  • decreased urination;

  • headache, dizziness, drowsiness;

  • muscle weakness;

  • dry skin, rash; or

  • abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to atropine / pralidoxime: intramuscular solution

General

In cases of organophosphate poisoning, toxic effects from the poisoning may be difficult to differentiate from adverse reactions to this product.[Ref]

Cardiovascular

Frequency not reported: Tachycardia, palpitations, flushing, increased systolic and diastolic blood pressure, circulatory collapse, arrhythmias, myocardial infarction[Ref]

Nervous system

Frequency not reported: Headache, dizziness, tremor, drowsiness, locomotor difficulties, medullary paralysis[Ref]

Dermatologic

Frequency not reported: Anhidrosis, maculopapular rash, petechial rash, scarletiniform rash[Ref]

Anhidrosis may produce heat intolerance and impair temperature regulation in hot environments.[Ref]

Gastrointestinal

Frequency not reported: Dryness of the mouth, constipation, abdominal distension, nausea, vomiting, dysphagia, paralytic ileus[Ref]

Ocular

Frequency not reported: Blurred vision, photophobia, diplopia, impaired accommodation, acute angle closure glaucoma[Ref]

Hypersensitivity

Hypersensitivity is usually seen as skin rashes, on occasion progressing to exfoliation.[Ref]

Frequency not reported: Hypersensitivity, anaphylactic reaction[Ref]

Genitourinary

Frequency not reported: Urinary hesitancy or retention, impotence[Ref]

Renal

Frequency not reported: Decreased renal function, transient elevations in creatinine phosphokinase[Ref]

Musculoskeletal

Frequency not reported: Muscular weakness[Ref]

Local

Frequency not reported: Muscle tightness and pain at the injection site[Ref]

Other

Frequency not reported: Fatigue[Ref]

Hepatic

Frequency not reported: Elevations in SGOT and/or SGPT[Ref]

SGOT and SGPT levels returned to normal in about 2 weeks.[Ref]

Respiratory

Frequency not reported: Hyperventilation[Ref]

More about DuoDote (atropine / pralidoxime)

Consumer resources

Other brands
ATNAA

Professional resources

Related treatment guides

References

1. "Product Information. ATNAA (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.

2. "Product Information. DuoDote (atropine-pralidoxime)." Meridian Medical Technologies Inc, Columbia, MD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.