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Dexrazoxane

Generic Name: dexrazoxane (dex ray ZOX ane)
Brand Name: Totect, Zinecard

Medically reviewed on May 7, 2018

What is dexrazoxane?

Dexrazoxane is used to protect the heart and other tissues from harmful side effects caused by certain cancer medications.

The Totect brand of dexrazoxane is used in men or women to treat a condition called extravasation (es-TRA-va-ZAY-shun). Extravasation happens when an injected medicine escapes from the blood vessels and circulates into tissues in the body. Serious tissue damage can occur when extravasation happens during injection of certain cancer medications.

The Zinecard brand of dexrazoxane is used to help prevent chemotherapy-related heart problems in women who are receiving doxorubicin for metastatic breast cancer. Zinecard is given only after you have received enough doxorubicin infusions to amount to a certain total dose.

Dexrazoxane may also be used for purposes not listed in this medication guide.

Important Information

Dexrazoxane can harm an unborn baby or cause birth defects if the mother or father is using dexrazoxane. Tell your caregivers if you are pregnant, or if you are a man and your sex partner is able to get pregnant.

You should not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medication (such as daunorubicin, epirubicin, idarubicin, or mitoxantrone).

Tell your doctor at once if you have signs of infection such as fever, chills, sore throat, easy bruising or bleeding, skin sores, or warmth and redness of any surgical incision.

Before taking this medicine

You should not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medication such as:

Tell your doctor if you have ever had:

Dexrazoxane can harm an unborn baby or cause birth defects if the mother or the father is receiving this medicine. Women should use effective birth control to prevent pregnancy while receiving dexrazoxane and for at least 6 months after the last dose. Men should use birth control during treatment and for at least 3 months after the last dose. Tell your doctor right away if a pregnancy occurs during this time.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because dexrazoxane may harm the baby if a pregnancy does occur.

You should not breast-feed while you are using dexrazoxane. Women receiving Totect should continue to not breast-feed for at least 2 weeks after the last dose.

How is dexrazoxane given?

Dexrazoxane is given as an infusion into a vein. A healthcare provider will give you this injection.

Totect is usually started within 6 hours after extravasation, and continued once daily for 3 days.

Zinecard is usually started 30 minutes before you receive your doxorubicin infusion. Zinecard is not given with your first dose of doxorubicin, but only after you've received prior doxorubicin doses up to a certain total amount.

Dexrazoxane can add to bone marrow suppression caused by chemotherapy. You may get infections more easily, even serious or fatal infections. Your doctor will need to examine you on a regular basis.

What happens if I miss a dose?

Since dexrazoxane is given by a healthcare professional as part of your chemotherapy treatment, you are not likely to miss a dose.

Call your doctor for instructions if you miss your chemotherapy appointment.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid after receiving dexrazoxane?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Dexrazoxane side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fever, chills, tiredness, mouth sores, skin sores;

  • easy bruising, unusual bleeding;

  • sore throat, cough, trouble breathing; or

  • bruising, swelling, warmth, redness, oozing, or bleeding of any surgical incision.

Common side effects may include:

  • nausea, vomiting;

  • fever;

  • infection after a surgery; or

  • pain where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Dexrazoxane dosing information

Usual Adult Dose for Cardiomyopathy Prophylaxis:

Zinecard (R):

Dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g. 500 mg/m2 dexrazoxane to 50 mg/m2 doxorubicin)
-Administer via IV infusion over 15 minutes.
-DO NOT administer via IV push.
-Administer doxorubicin within 30 minutes of completion of dexrazoxane infusion; do not administer doxorubicin before dexrazoxane.

Comments:
-Do not use with the initiation of doxorubicin therapy.

Use(s): Reducing incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m2 and who will continue to receive doxorubicin.

Usual Adult Dose for Extravasation:

Totect (R):

Recommended doses:
Day one: 1000 mg/m2 IV over 1 to 2 hours
Day two: 1000 mg/m2 IV over 1 to 2 hours
Day three: 500 mg/m2 IV over 1 to 2 hours

Maximum doses:
Day one: 2000 mg
Day two: 2000 mg
Day three: 1000 mg

Comments:
-Product must be diluted with 50 mL of 0.167 M sodium lactate injection solution prior to administration.
-Initiate first infusion as soon as possible and within the first 6 hours of extravasation.
-Start day 2 and 3 treatments at the same hour as the first day (give or take 3 hours).
-Remove cooling features such as ice packs (if used) at least 15 minutes before administration to allow sufficient blood flow to extravasation area.

Use(s): Extravasation resulting from intravenous anthracycline chemotherapy

What other drugs will affect dexrazoxane?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect dexrazoxane, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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