Skip to main content

Dexrazoxane Side Effects

Medically reviewed by Last updated on Jun 2, 2023.

Applies to dexrazoxane: intravenous powder for solution.

Serious side effects of Dexrazoxane

Along with its needed effects, dexrazoxane may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dexrazoxane:

More common

Less common

Other side effects of Dexrazoxane

Some side effects of dexrazoxane may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

For Healthcare Professionals

Applies to dexrazoxane: intravenous powder for injection.


Adverse events reported are from clinical trials where patients were also receiving chemotherapy while on this drug, and reflect the combination of this drug, already administered chemotherapy, and the patients underlying condition.[Ref]


Very common (10% or more): Nausea (77%), vomiting (59%), stomatitis (34%), diarrhea (21%)

Common (1% to 10%): Abdominal pain, constipation, esophagitis, dysphagia[Ref]


Very common (10% or more): Decreased white blood count (73%), decreased neutrophils (61%) decreased hemoglobin (43%), decreased platelets (23%)

Common (1% to 10%): Anemia[Ref]


Very common (10% or more): Alopecia (up to 100%)

Common (1% to 10%): Streaking/erythema, urticaria[Ref]


Very common (10% or more): Injection site pain/discomfort (16%)

Common (1% to 10%): Injection site phlebitis, extravasation[Ref]

Nervous system

Very common (10% or more): Neurotoxicity (17%), dizziness (11%)

Common (1% to 10%): Headache[Ref]


Very common (10% or more): Increased AST (28%), increased ALT (22%)

Common (1% to 10%): Increased LDH, increased alkaline phosphatase[Ref]


Very common (10% or more): Anorexia (42%)

Common (1% to 10%): Increased calcium total, decreased sodium[Ref]


Very common (10% or more): Infection (23%), sepsis (17%), postoperative infection (16%)

Common (1% to 10%): Pneumonia[Ref]


Very common (10% or more): Fever (34%), fatigue (61%), pain on injection (13%), edema peripheral (10%)[Ref]


Very common (10% or more): Increased creatinine (14%)[Ref]


Common (1% to 10%): Cardiac disorders, phlebitis, hemorrhage[Ref]


Common (1% to 10%): Depression, insomnia[Ref]


Common (1% to 10%): Dyspnea, cough[Ref]


1. Product Information. Totect (dexrazoxane). Cumberland Pharmaceuticals Inc. 2008.

2. Product Information. Zinecard (dexrazoxane). Pfizer U.S. Pharmaceuticals Group. 2001;PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.