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Dexrazoxane Side Effects

For the Consumer

Applies to dexrazoxane: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by dexrazoxane. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking dexrazoxane:

More common:
  • Bluish color
  • changes in skin color
  • chest pain
  • cold hands and feet
  • cough or hoarseness
  • difficult or labored breathing
  • fever or chills
  • lower back or side pain
  • pain, redness, or swelling in arm or leg
  • painful or difficult urination
  • pale skin
  • shortness of breath
  • sneezing
  • sore throat
  • swelling of hands, ankles, feet, or lower legs
  • tenderness
  • tightness in chest
  • troubled breathing
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
Less common:
  • Black, tarry stools
  • chest discomfort
  • fast, irregular, or pounding heartbeat
  • pain at place of injection
  • ulcers, sores, or white spots in mouth

Minor Side Effects

Some of the side effects that can occur with dexrazoxane may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea
  • difficulty having a bowel movement (stool)
  • discouragement
  • dizziness
  • feeling sad or empty
  • hair loss, thinning of hair
  • headache
  • irritability
  • lack or loss of appetite
  • loss of interest or pleasure
  • muscle pain, spasms, cramps, or stiffness
  • nausea
  • stomach pain
  • trouble concentrating
  • trouble sleeping
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to dexrazoxane: intravenous powder for injection


Gastrointestinal side effects including nausea (43%), vomiting (19%), diarrhea (11%), abdominal pain (6%), and constipation (6%) have been reported.


General side effects including pyrexia (21%), postoperative infection (16%), fatigue (13%), peripheral edema (10%), chest pain, chest discomfort, decreased drug effect, hyperpyrexia, and decreased therapeutic response have been reported.


Local side effects including injection site pain (16%) and injection site phlebitis (6%) have been reported.


Cardiovascular side effects including vascular disorders (15%) and cardiac disorders (5%) have been reported.


Dermatologic side effects including alopecia (14%) have been reported.


Musculoskeletal side effects including "musculoskeletal and connective tissue disorders" (13%) have been reported.

Nervous system

Nervous system side effects including dizziness (11%) and headache (6%) have been reported.


Respiratory side effects including dyspnea (8%), pneumonia (6%), and cough (5%) have been reported.


Psychiatric side effects including depression (8%), anorexia (5%), and insomnia (5%) have been reported.


Hematologic side effects including anemia (6%), decreased WBC, decreased neutrophils, and decreased platelets have been reported.


Hepatic side effects including increased bilirubin, increased AST, increased ALT, increased alkaline phosphatase, and increased LDH have been reported


Metabolic side effects including increased creatinine, decreased sodium, and increased total calcium have been reported.

Not all side effects for dexrazoxane may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.