Medically reviewed by Drugs.com. Last updated on Jan 22, 2021.
Applies to the following strengths: 250 mg; 500 mg
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Cardiomyopathy Prophylaxis
Dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g. 500 mg/m2 dexrazoxane to 50 mg/m2 doxorubicin)
-Administer via IV infusion over 15 minutes.
-DO NOT administer via IV push.
-Administer doxorubicin within 30 minutes of completion of dexrazoxane infusion; do not administer doxorubicin before dexrazoxane.
-Do not use with the initiation of doxorubicin therapy.
Use(s): Reducing incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin dose of 300 mg/m2 and who will continue to receive doxorubicin.
Usual Adult Dose for Extravasation
Day one: 1000 mg/m2 IV over 1 to 2 hours
Day two: 1000 mg/m2 IV over 1 to 2 hours
Day three: 500 mg/m2 IV over 1 to 2 hours
Day one: 2000 mg
Day two: 2000 mg
Day three: 1000 mg
-Product must be diluted with 50 mL of 0.167 M sodium lactate injection solution prior to administration.
-Initiate first infusion as soon as possible and within the first 6 hours of extravasation.
-Start day 2 and 3 treatments at the same hour as the first day (give or take 3 hours).
-Remove cooling features such as ice packs (if used) at least 15 minutes before administration to allow sufficient blood flow to extravasation area.
Use(s): Extravasation resulting from intravenous anthracycline chemotherapy
Renal Dose Adjustments
CrCl under 40 mL/min: Reduce dose by half
Liver Dose Adjustments
Extravasation: Not recommended in hepatic impairment.
-Perform routing liver function tests before each administration if patient has known liver function disorders.
Cardiomyopathy prophylaxis: Since doxorubicin dose reduction is recommended, reduce dose of dexrazoxane proportionally (maintaining the 10:1 ratio).
-Do not use with non-anthracycline chemotherapy regimens.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
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- Drug class: miscellaneous uncategorized agents
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