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Calamine Plain (topical)

Generic name: calamine (topical) [ KAL-a-mine ]
Brand name: Calamine Plain topical
Drug class: Miscellaneous topical agents

Medically reviewed by on Aug 14, 2023. Written by Cerner Multum.

What is Calamine Plain?

Calamine Plain is an anti-itch medicine that works by causing a cooling sensation as it evaporates on your skin. Calamine Plain also dries oozing or weeping from minor skin irritation.

Calamine Plain topical (for the skin) is used to treat itching and skin irritation caused by chickenpox, insect bites or stings, measles, eczema, sunburn, poison ivy, and other minor skin conditions.

Calamine Plain topical may also be used for purposes not listed in this medication guide.

Calamine Plain side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Calamine Plain may cause serious side effects. Call your doctor at once if you have:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Calamine Plain topical if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to use Calamine Plain Plain if you have other medical conditions, especially any allergies.

It is not known whether Calamine Plain topical will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant.

It is not known whether calamine topical passes into breast milk or if it could harm a nursing baby. Do not use this medicine without a doctor's advice if you are breast-feeding a baby.

How should I use Calamine Plain?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Before you apply Calamine Plain topical, wash the skin with soap and water. Allow the skin to dry completely.

Shake the Calamine Plain lotion well just before each use.

Apply Calamine Plain topical directly to the skin and rub in gently, allowing it to dry on your skin. You may also use a cotton ball to smooth the medicine onto your skin.

Wash your hands with soap and water after applying the medicine.

Calamine Plain lotion may leave a thin film on the skin as it dries. You may cover the treated area with loose clothing, but Calamine Plain can stain fabrics it comes in contact with.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if your symptoms clear up and then come back.

Store at room temperature away from moisture and heat. Do not freeze or refrigerate.

What happens if I miss a dose?

Since Calamine Plain Plain is used when needed, you may not be on a dosing schedule. If you are on a schedule, apply the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of Calamine Plain is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using Calamine Plain?

Do not take by mouth. Calamine Plain topical is for use only on the skin. If Calamine Plain Plain gets in your eyes, nose, mouth, rectum, or vagina, rinse with water.

Avoid using other medications on the areas you treat with Calamine Plain unless your doctor tells you to.

What other drugs will affect Calamine Plain?

It is not likely that other drugs you take orally or inject will have an effect on topically applied Calamine Plain. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

More about Calamine Plain (calamine topical)

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.