Skip to main content

Actoplus Met XR

Generic name: metformin and pioglitazonemet-FOR-min-and-PYE-o-GLI-ta-zone ]
Brand names: Actoplus Met, Actoplus Met XR
Drug class: Antidiabetic combinations

Medically reviewed by Drugs.com on Jul 31, 2023. Written by Cerner Multum.

What is Actoplus Met XR?

Actoplus Met XR is a combination of two oral diabetes medicines that help control blood sugar levels.

Actoplus Met XR is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who do not use daily insulin injections. This medicine is not for treating type 1 diabetes.

Actoplus Met XR may also be used for purposes not listed in this medication guide.

Actoplus Met XR side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some people using Actoplus Met XR develop lactic acidosis, which can be fatal. Get emergency medical help if you have even mild symptoms such as:

Actoplus Met XR may cause serious side effects. Call your doctor at once if you have:

Common side effects of Actoplus Met XR may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Warnings

You should not use Actoplus Met XR if you have severe heart failure, severe kidney disease, active bladder cancer, metabolic acidosis, or ketoacidosis (call your doctor for treatment).

Actoplus Met XR can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain.

If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Actoplus Met XR.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

Before taking this medicine

You should not use this medicine if you are allergic to metformin or pioglitazone, or if you have:

If you need to have surgery or any type of x-ray or CT scan using a dye that is injected into your veins, you may need to temporarily stop taking Actoplus Met XR. Be sure your caregivers know ahead of time that you are using this medicine.

Tell your doctor if you have ever had:

This medication may increase your risk of developing bladder cancer. Talk with your doctor about your specific risk.

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, a severe infection, chronic alcoholism, or if you are 65 or older. Ask your doctor about your risk.

Actoplus Met XR may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.

Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy. Talk to your doctor about your risk.

Women may be more likely to have a broken bone while using Actoplus Met XR. Talk with your doctor about ways to keep your bones healthy.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Actoplus Met XR is not approved for use by anyone younger than 18 years old.

How should I take Actoplus Met XR?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take Actoplus Met XR with meals. Take the extended-release tablet once daily with your evening meal.

Swallow the tablet whole and do not crush, chew, or break it.

You may have low blood sugar (hypoglycemia) and feel very hungry, dizzy, irritable, confused, anxious, or shaky. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar (fruit juice, hard candy, crackers, raisins, or non-diet soda).

Your doctor may prescribe a glucagon injection kit in case you have severe hypoglycemia. Be sure your family or close friends know how to give you this injection in an emergency.

Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.

Actoplus Met XR is only part of a complete treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor's instructions very closely.

If you take extra vitamin B12 while you are taking Actoplus Met XR, take only the amount of vitamin B12 that your doctor has prescribed.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Ozempic, metformin, Trulicity, Lantus, Tresiba, Basaglar, Victoza

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of metformin can cause lactic acidosis, which can be fatal.

What should I avoid while taking Actoplus Met XR?

Avoid drinking alcohol. It can lower your blood sugar and may increase your risk of lactic acidosis.

What other drugs will affect Actoplus Met XR?

Many drugs can affect Actoplus Met XR, making Actoplus Met XR less effective or increasing your risk of lactic acidosis. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does ActoPlus Met XR interact with my other drugs?

Enter medications to view a detailed interaction report using our Drug Interaction Checker.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.