Skip to main content

Vinorelbine (Monograph)

Brand name: Navelbine
Drug class: Antineoplastic Agents
- Vinca Alkaloids
- Antimitotic Agents
VA class: AN900
Chemical name: 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*, R*)]-2,3-dihydroxybutane dioate (1:2)
Molecular formula: C45H54N4O8•2C4H6O6

Warning

    Experience of Supervising Clinician

  • Use under supervision of a qualified clinician experienced in therapy with antineoplastic agents.b c

    Administration Warnings

  • For IV use only.b c

  • Fatal if given intrathecally.b c (See Intrathecal Administration under Cautions.)

  • Extremely important to properly place IV needle or catheter before vinorelbine is injected.b c

  • Local tissue necrosis and/or thrombophlebitis, if extravasation occurs.b c

    Granulocytopenia

  • Severe granulocytopenia may occur, possibly resulting in increased susceptibility to infection.b c

  • Granulocyte counts should be ≥1000/mm3 prior to administration of vinorelbine.b c

  • Adjust dosage according to complete blood counts with differentials obtained on day of treatment.b c

Introduction

Antineoplastic agent; semisynthetic vinca alkaloid.1 4 21 b c

Uses for Vinorelbine

Non-Small Cell Lung Cancer

Used alone or in combination with cisplatin as first-line therapy in ambulatory patients for the palliative treatment of unresectable, advanced non-small cell lung cancer (NSCLC).1 19 91 b c

Used alone or in combination with cisplatin in patients with Stage IV NSCLC.1 19 91 b c

Use in combination with cisplatin is preferred treatment of advanced NSCLC in patients with good performance status because of improved response and survival.1 12 19 99 112

Used in combination with cisplatin in patients with Stage III NSCLC.1 19 91 b c

Use in combination with cisplatin is being investigated for adjuvant treatment of completely resected NSCLC† [off-label].110 111

Breast Cancer

Use in combination with trastuzumab is being investigated for the treatment of HER2-overexpressing metastatic breast cancer† [off-label].19 104 105 106

Has been used as first-line or salvage therapy for metastatic breast cancer in combination with various other agents† [off-label], including anthracyclines (e.g., doxorubicin), fluoropyrimidines (e.g., fluorouracil, capecitabine), mitoxantrone, cisplatin, taxanes (e.g., docetaxel, paclitaxel), ifosfamide, or gemcitabine.122

Has been used as monotherapy in first-line or salvage (e.g., second-line or subsequent) treatment of metastatic breast cancer† [off-label].19 106

Cervical Cancer

Use in the treatment of metastatic or recurrent cervical cancer† [off-label] is being investigated.19 97 98

Use in combination with other antineoplastic agents (e.g., cisplatin) is being evaluated in patients with metastatic or recurrent cervical cancer†.98

Adult Soft Tissue Sarcomas

Has been used in the treatment of adult soft tissue sarcomas†.19

Esophageal Cancer

Has been used in the treatment of esophageal cancer†.19

Vinorelbine Dosage and Administration

General

Administration

IV Administration

For solution and drug compatibilty information, see Compatibility under Stability.

Administer IV only by individuals experienced in the administration of the drug.b c

Very irritating; do not administer IM, sub-Q, or intrathecally.1 b c Intrathecal administration of other vinca alkaloids has resulted in death.1 b c (See Boxed Warning.)

Management of patients mistakenly receiving intrathecal vinorelbine is a medical emergency.b c (See Intrathecal Administration under Cautions.)

Administer by IV injection, usually at weekly intervals.1 b c Inject the diluted injection concentrate into a free-flowing IV infusion or a large central vein.1 3 9 20

Has been administered as a continuous IV infusion†.44 72 73

Extravasation

Extremely important to ensure that needle or catheter is securely within vein to avoid extravasation.1 b c If extravasation occurs, discontinue injection immediately and administer remainder of dose through another vein.1 b c

Dilution

Dilute injection concentrate prior to injection in a syringe with 5% dextrose injection or 0.9% sodium chloride injection to a final vinorelbine concentration of 1.5–3 mg/mL or in an IV bag with 5% dextrose injection, 0.9% sodium chloride injection, 0.45% sodium chloride injection, 5% dextrose and 0.45% sodium chloride injection, Ringer’s injection, or lactated Ringer’s injection to a final vinorelbine concentration of 0.5–2 mg/mL.1 b c

Rate of Administration

Administer over 6–10 minutes into the side port closest to the IV bag of a free-flowing IV infusion or into a large central vein.1 3 9 Follow by flushing with at least 75–125 mL of 0.9% sodium chloride injection or 5% dextrose injection over a period of 10 minutes.1 3 9 73 b c

Dispensing Precautions

When dispensing, must label syringe holding the individual dose with the statement: “Warning: For IV use only. Fatal if given intrathecally.”1 b c

Dosage

Available as vinorelbine tartrate; dosage expressed in terms of vinorelbine.1 b c

Adults

Non-small Cell Lung Cancer
Monotherapy
IV

Initially, 30 mg/m2 once weekly until disease progression or dose-limiting toxicity occurs.1 b

Combination Therapy
IV

Vinorelbine 25 mg/m2 once weekly in combination with cisplatin 100 mg/m2 every 4 weeks.1 b

Alternatively, vinorelbine 30 mg/m2 once weekly in combination with cisplatin (120 mg/m2 on days 1 and 29 and then once every 6 weeks).1 b

Breast Cancer†
First-line or Salvage (second-line or subsequent) Monotherapy
IV

Initially, 20–30 mg/m2 (infused over 20–60 minutes) weekly.3 5 9 20 21 22 23 24 25 26 27 28 30 31 32 33 34 35

Alternatively, 30 mg/m2 weekly as a direct IV injection over 3–5 minutes30 or as a rapid IV dose.3 20 34 However, manufacturers recommend to infuse over 6–10 minutes to improve local tolerance.73 b c

Adjust doses (e.g., delay or reduce doses) throughout therapy to minimize potential toxicity.3 5 20 21 22 23 24 25 27 28 30 31 32 33 34 35 52

Dosage Modification for Toxicity
Hematologic Toxicity

Granulocyte counts should be ≥1000/mm3 prior to administration.b c

Perform CBC with differential before administration of each dose; consider withholding next dose in patients with granulocytopenia or infectious complications.b c

Adjust dosage according to hematologic toxicity.b c

Table 1. Dosage Adjustments Based on Granulocyte Counts1bc

Granulocytes on Day of Treatment (cells/mm3)

Percentage of Starting Dose of Vinorelbine

≥1500

100%

1000 to 1499

50%

<1000

Do not administer. Repeat granulocyte count in 1 week. If 3 consecutive weekly doses are held because granulocyte count is <1,000/mm3, discontinue drug.
Table 2. Dosage Adjustments Based on Granulocyte Counts. If fever and/or sepsis is present while granulocytopenic or 2 consecutive weekly dosages held due to granulocytopenia, reduce subsequent dosages by the following:1b

Granulocytes on Day of Treatment (cells/mm3)

Percentage of Starting Dose of Vinorelbine

≥1500

75%

1000 to 1499

37.5%

<1000

Do not administer. Repeat granulocyte count in 1 week. If 3 consecutive weekly doses are held because granulocyte count is <1,000/mm3, discontinue drug.
Hepatic Toxicity

Adjust dosage according to hepatic toxicity.b c

Reduce dosage in patients who develop hyperbilirubinemia based on total bilirubin levels.1 b c

Adjust dosage to lower end of dosage range for patients with concurrent hepatic impairment and hematologic toxicity.1 b c

Table 3. Dose Modification Based on Total Bilirubin1bc

Total Bilirubin (mg/dL)

Percentage of Starting Dose of Vinorelbine

≤2

100%

2.1 to 3

50%

>3

25%
Neurologic Toxicity

If manifestations of moderate or severe (grade 2 or higher) neurotoxicity occur, discontinue therapy immediately.1 b c

Prescribing Limits

Adults

Non-small Cell Lung Cancer
IV

Stage III NSCLC: Maximum 4 cycles of chemotherapy.99

Stage IV NSCLC: Maximum 4 cycles if disease not responding to treatment; maximum 6 cycles of chemotherapy if disease responds to treatment.99

Special Populations

Hepatic Impairment

Adjust dosage to lower end of dosage range for patients with concurrent hepatic impairment and hematologic toxicity.1 b c

Reduce dosage in patients who develop hyperbilirubinemia.1 b c (See Hepatic Toxicity under Dosage and Administration.)

Renal Impairment

No dosage adjustments required in patients with renal impairment.1 b c

Detailed Vinorelbine dosage information

Cautions for Vinorelbine

Contraindications

Warnings/Precautions

Warnings

Intrathecal Administration

Fatal if administered intrathecally; management of patients mistakenly receiving intrathecal vinorelbine is a medical emergency.1 73

Prognosis to date for patients inadvertently receiving another vinca alkaloid generally has been poor despite immediate efforts to remove spinal fluid and flush with lactated Ringer’s injection and other solutions, with such efforts failing to prevent ascending paralysis and death in almost all cases.93 94

In one adult patient, progression of paralysis was stopped when treatment was initiated immediately after inadvertent intrathecal injection of vincristine.93

Treatment consisted of immediate removal of as much CSF as safely possible via lumbar access, followed by flushing of the subarachnoid space with lactated Ringer’s solution infused continuously at a rate of 150 mL/hour through a catheter in a cerebral lateral ventricle and removal of fluid through a lumbar access.93

As soon as available, fresh frozen plasma (25 mL) diluted in 1 L of lactated Ringer’s solution was infused through the cerebral ventricular catheter at a rate of 75 mL/hour with removal of fluid through the lumbar access.93 The rate of infusion was adjusted to maintain a CSF protein concentration of 150 mg/dL.93 Glutamic acid was administered in a dose of 10 g given IV over 24 hours, followed by 500 mg orally 3 times daily for 1 month or until stabilization of neurologic status.93 94 The role of glutamic acid in this treatment is uncertain.93

Hematologic Effects

Granulocytopenia usually is the dose-limiting factor in therapy.b c Nadir in granulocyte count generally occurs 7–10 days after administration and recovery usually occurs within another 7–14 days.1 5 21 23 26 b c

Perform CBC with differential before administration of each dose.b c

Do not administer if granulocyte counts <1000/mm3.b c

Carefully monitor patients with severe granulocytopenia for evidence of infection and/or fever.b c (See Hematologic Toxicity under Dosage and Administration.)

Respiratory Effects

Acute shortness of breath and severe bronchospasm have occurred rarely; most frequently when mitomycin was administered concomitantly.1 b c May require treatment with supplemental oxygen, bronchodilators, and/or corticosteroids, particularly with preexisting pulmonary dysfunction.b c

Fatal interstitial pulmonary changes and acute respiratory distress syndrome (ARDS) have been reported.1 b c Mean time to onset of symptoms was 1 week (range: 3–8 days).b c Evaluate promptly patients with preexisting pulmonary dysfunction or new onset of dyspnea, cough, hypoxia, or other symptoms.b c

GI Effects

GI effects (some fatal), including severe constipation (grade 3 or 4), paralytic ileus, intestinal obstruction, necrosis, and/or perforation reported.b c

Fetal/Neonatal Morbidity and Mortality

May cause fetal harm; teratogenicity and embryolethality demonstrated in animals.1 b c Avoid pregnancy during therapy.1 b c If used during pregnancy or patient becomes pregnant, apprise of potential fetal hazard.1 b c

Major Toxicities

Hepatic Toxicity

Adjust dosage according to hepatic toxicity.b c (See Hepatic Toxicity under Dosage and Administration.)

General Precautions

Administer only under constant supervision by clinicians experienced in therapy with chemotherapeutic agents.1 b c

Pattern of adverse effects appears to be similar in patients receiving monotherapy or combination therapy with vinorelbine.1 b c

Most drug-related adverse effects are reversible.b c If severe adverse effects occur, reduce dosage or discontinue therapy.b c Reinstitute therapy with caution; possible recurrence of toxicity.b c

Compromised Bone Marrow Reserve

Use with extreme caution in patients whose bone marrow reserve may have been compromised by prior chemotherapy or radiation therapy, or whose marrow function is recovering from previous cytotoxic therapy.b c

Nervous System Effects

Monitor patients with preexisting neuropathy, regardless of etiology, for new or worsening signs and symptoms, while receiving the drug.b c

Eye Contamination

Avoid contamination of the eye(s) with the drug; severe irritation may occur with accidental exposure.b c If contamination occurs, immediately wash eye(s) with water.b c

Hepatic Effects

Transient elevations of liver enzymes were reported without clinical symptoms.1 21 26 80 (See Hepatic Toxicity under Dosage and Administration.)

Specific Populations

Pregnancy

Category D.c (See Fetal/Neonatal Morbidity and Mortality under Cautions.)

Lactation

Not known whether vinorelbine is distributed into milk.1 b c Discontinue nursing or drug.1 b c

Pediatric Use

Safety and efficacy in children <18 years of age have not been established.1 20 b c

Limited number of pediatric patients with recurrent solid malignant tumors (e.g., rhabdomyosarcoma/undifferentiated sarcoma, neuroblastoma, CNS tumors) have received vinorelbine dosages similar to adults; no clinical efficacy reported.b c Toxicities were similar to adults.b c

Geriatric Use

No overall differences in safety and efficacy relative to younger adults.1 b c Although response in patients ≥65 years of age does not appear to differ from that in younger adults, possibility exists of greater sensitivity in some geriatric patients.1 b c

Hepatic Impairment

No evidence that vinorelbine-associated toxicity is increased in patients with elevated hepatic enzymes.b c

Administer with caution and reduce dosage in patients with severe hepatic impairment, since drug is metabolized by hepatic enzymes and clinical experience in severe hepatic impairment is limited.b c (See Hepatic Toxicity under Dosage and Administration.)

Renal Impairment

Dosage reduction in patients with renal impairment does not appear to be necessary.1 b c

Common Adverse Effects

Myelosuppression, anemia, injection site reactions (e.g., erythema, pain, chemical phlebitis, vein discoloration), fatigue, chest pain, constipation, nausea, vomiting, hypertension, malaise, paresthesia, peripheral neuropathy, loss of deep tendon reflexes, diarrhea, asthenia.1 b c

Drug Interactions

Drugs Affecting Hepatic Microsomal Enzymes

Metabolized by CYP isoenzymes, principally CYP3A.1 b c

Inhibitors of CYP3A: Potential pharmacokinetic interaction (inhibition of vinorelbine metabolism). 1 b Use concomitantly with caution.1 b c

Ototoxic Drugs

Since varying degrees of permanent or temporary hearing impairment associated with eighth cranial nerve damage have been reported in patients receiving vinca alkaloids, use concomitantly with other potentially ototoxic drugs with extreme caution.1 93 (See Specific Drugs under Interactions.)

Specific Drugs and Procedures

Drug

Interaction

Comments

Aprepitant

May inhibit or induce CYP3A4103

Use concomitantly with caution and careful monitoring103

Consider dosage reduction of vinorelbine 103

Cisplatin

Incidence of of granulocytopenia increased with combined use1 b c

Closely monitor CBC with differentials before, during and after therapy1 b c

Itraconazole

Possible increased plasma concentrations of vinorelbine102

Possible neurotoxicity; consider vinorelbine dosage reduction102

Use with caution, earlier onset and/or increased severity of adverse effects may occur1 b c

Ketoconazole

Possible increased plasma concentrations of vinorelbine102

Possible neurotoxicity; consider vinorelbine dosage reduction102

Use with caution, earlier onset and/or increased severity of adverse effects may occur1 b c

Mitomycin

Possible acute pulmonary reactions 1 b (See Respiratory Effects under Cautions)

Ototoxic drugs (e.g., platinum-containing antineoplastic agents)

Potential additive ototoxic effect1 93

Varying degrees of permanent or temporary hearing impairment associated with eighth cranial nerve damage use with extreme caution1 93

Paclitaxel

Possible increased risk of neuropathy1

Monitor for signs and symptoms of neuropathy1 b c

Radiation Therapy

Prior or concomitant radiation may result in radiosensitizing effectsb c

Voriconazole

Possible increased plasma concentrations of vinorelbine102

Possible neurotoxicity; consider vinorelbine dosage reduction102

Use with caution, earlier onset and/or increased severity of adverse effects may occur1 b c
Vinorelbine drug interactions (more detail)

Vinorelbine Pharmacokinetics

Absorption

Plasma Concentrations

Following IV administration, plasma concentrations decline in a triphasic manner with an initial rapid decrease.1 b c

Distribution

Extent

Distributed into peripheral compartments.1 b c

Crosses the placenta in animals; not known if crosses the placenta in humans.b c

Not known whether vinorelbine is distributed into human milk.1 b c

Plasma Binding

High degree (79.6–91.2% in cancer patients) of binding to human platelets and lymphocytes.1 b c

Elimination

Metabolism

Extensively metabolized, mainly in the liver by CYP3A isoenzymes to vinorelbine N-oxide and deacetylvinorelbine (main metabolite with antitumor activity similar to the parent drug).1 b c

Elimination Route

Excreted, mainly as unchanged drug, in urine (11–18%) and in feces (46%).1 b c

Half-life

Mean terminal elimination half-life: 27.7–43.6 hours.1 b c

Special Populations

Effect of renal and/or hepatic impairment on the elimination of vinorelbine not evaluated.1

Metabolism by CYP3A isoenzymes may be impaired in patients with hepatic impairment.b c

Limited data indicate that disposition of drug in geriatric patients is similar to that in younger adults.1 b c

Stability

Storage

Parenteral

Injection

2–8°C; do not freeze.1 b c ; protect from light.1 b c

Unopened vials stable at 25°C for up to 72 hours.1 b c

May store diluted solutions at normal room light (in polypropylene syringes or polyvinyl chloride bags) at 5–30°C up to 24 hours.b c

Compatibility

Parenteral

Solution Compatibilityb c HID

Compatible

Dextrose 5% in water

Sodium chloride 0.9%
Drug Compatibility
Y-Site CompatibilityHID

Compatible

Amikacin sulfate

Aztreonam

Bleomycin sulfate

Bumetanide

Buprenorphine HCl

Butorphanol tartrate

Calcium gluconate

Carboplatin

Carmustine

Cefotaxime sodium

Ceftazidime

Ceftizoxime sodium

Chlorpromazine HCl

Cimetidine HCl

Cisplatin

Clindamycin phosphate

Cyclophosphamide

Cytarabine

Dacarbazine

Dactinomycin

Daunorubicin HCl

Dexamethasone sodium phosphate

Diphenhydramine HCl

Doxorubicin HCl

Doxorubicin HCl liposome injection

Doxycycline hyclate

Droperidol

Enalaprilat

Etoposide

Famotidine

Filgrastim

Floxuridine

Fluconazole

Fludarabine phosphate

Gallium nitrate

Gatifloxacin

Gemcitabine HCl

Gentamicin sulfate

Granisetron HCl

Haloperidol lactate

Hydrocortisone sodium phosphate

Hydrocortisone sodium succinate

Hydromorphone HCl

Hydroxyzine HCl

Idarubicin HCl

Ifosfamide

Imipenem–cilastatin sodium

Lorazepam

Mannitol

Melphalan HCl

Meperidine HCl

Mesna

Methotrexate sodium

Metoclopramide HCl

Metronidazole

Mitoxantrone HCl

Morphine sulfate

Nalbuphine HCl

Ondansetron HCl

Oxaliplatin

Potassium chloride

Prochlorperazine edisylate

Promethazine HCl

Rantidine HCl

Streptozocin

Teniposide

Ticarcillin disodium–clavulanate potassium

Tobramycin sulfate

Vancomycin HCl

Vinblastine sulfate

Vincristine sulfate

Zidovudine

Incompatible

Acyclovir sodium

Allopurinol sodium

Aminophylline

Amphotericin B

Amphotericin B cholesteryl sulfate complex

Ampicillin sodium

Cefazolin sodium

Cefotetan disodium

Ceftriaxone sodium

Cefuroxime sodium

Co-trimoxazole

Fluorouracil

Furosemide

Ganciclovir sodium

Lansoprazole

Methylprednisolone sodium succinate

Mitomycin

Sodium bicarbonate

Thiotepa

Variable

Heparin sodium

Actions

Advice to Patients

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Vinorelbine Tartrate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

For injection concentrate, for IV infusion only

10 mg (of vinorelbine)/mL (10 and 50 mg)

Navelbine

Pierre Fabre

Vinorelbine Tartrate for Injection

AHFS DI Essentials™. © Copyright 2025, Selected Revisions December 1, 2007. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration.

References

1. GlaxoSmithKline. Navelbine (vinorelbine tartrate) injection prescribing information. Research Triangle Park, NC; 2002 Nov.

2. Glaxo Wellcome Inc. Treatment IND protocol: Treatment IND for patients with unresectable stage III or IV NSLC and product information. Research Triangle Park, NC: 1994 Mar.

3. Glaxo Wellcome Inc. Navelbine injection product information. Research Triangle Park, NC: 1994 Mar.

4. Xiao-Jian Z, Rahmani R. Preclinical and clinical pharmacology of vinca alkaloids. Drugs. 1992; 44(Suppl 4):1-16. https://pubmed.ncbi.nlm.nih.gov/1283846

5. Cvitkovic E, Izzo J. The current and future place of vinorelbine in cancer therapy. Drugs. 1992; 44(Suppl 4):36-45. https://pubmed.ncbi.nlm.nih.gov/1283849

6. Fellous A. Biochemical effects of navelbine on tubulin and associated proteins. Semin Oncol. 1989;16(Suppl 4):9-14.

7. Binet S. In situ analysis of the action of navelbine on various types of microtubules using immunofluorescence. Semin Oncol. 1989; 16(Suppl 4):5-8. https://pubmed.ncbi.nlm.nih.gov/2652320

8. Binet S. Immunofluorescence study of the action of navelbine, vincristine and vinblastine on mitotic and axonal microtubules. Int J Cancer. 1990; 46:262-6. https://pubmed.ncbi.nlm.nih.gov/2200754

9. Goa KL, Faulds F. Vinorelbine a review of its pharmacological properties and clinical use in cancer chemotherapy. Drugs Aging. 1994; 5:200-34. https://pubmed.ncbi.nlm.nih.gov/7803948

10. Budman DR. New vinca alkaloids and related compounds. Semin Oncol. 1992; 19:639-45. https://pubmed.ncbi.nlm.nih.gov/1462165

11. Depierre A, Chastang C, Quoix E et al. Vinorelbine versus vinorelbine plus cisplatin in advanced non-small cell lung cancer: a randomized trial. Ann Oncol. 1994; 5:37-42. https://pubmed.ncbi.nlm.nih.gov/8172790

12. Le Chevalier T, Brisgand D, Douillard J et al. Randomized study of vinorelbine and cisplatin versus vindesine and cisplatin versus vinorelbine alone in advanced non-small-cell lung cancer: Results of a European multicenter trial including 612 patients. J Clin Oncol. 1994; 12:360-67. https://pubmed.ncbi.nlm.nih.gov/8113844

13. Burroughs Wellcome Company, Research Triangle Park, NC: Personal communication.

14. Horwitz SB. Mechanism of action of taxol. Trends Pharmacol Sci. 1992; 13:134-6. https://pubmed.ncbi.nlm.nih.gov/1350385

15. Rowinsky EK, Cazenave LA, Donehower RC. Taxol: a novel investigational antimicrotubule agent. Natl Cancer Inst. 1990; 82:1247-59.

16. Gregory RE, DeLisa AF. Paclitaxel: a new antineoplastic agent for refractory ovarian cancer. Clin Pharm. 1993; 12:401-15. https://pubmed.ncbi.nlm.nih.gov/7691462

17. Hepperle M, Georg G. Taxol analogs. Drugs Future. 1994; 19:573-84.

18. Balbiani L, Coppola F, Blajman C et al. Navelbine (NVB) vs NVB plus cisplatin (P) in non-small cell lung cancer (NSCLC). Proc Annu Meet Am Soc Clin Oncol. 1993; 12:A1185.

19. Anon. Drugs of choice for cancer. Treat Guidel Med Lett. 2003; 1:41-52. https://pubmed.ncbi.nlm.nih.gov/15529105

20. Burroughs Wellcome, Research Triangle Park, NC: Personal communication.

21. Toso C, Lindley C. Vinorelbine: a novel vinca alkaloid. Am J Health-Syst Pharm. 1995; 52:1287-304. https://pubmed.ncbi.nlm.nih.gov/7656116

22. Marty M, Extra JM, Dieras S et al. A review of the antitumor activity of vinorelbine in breast cancer. Drugs. 1992; 44(Suppl 4):29-35.

23. Weber B, Vogel C, Jones S et al. Intravenous vinorelbine (NAVELBINE) as first- and second-line therapy in advanced breast cancer. J Clin Oncol. 1995; 13:2722-30. https://pubmed.ncbi.nlm.nih.gov/7595730

24. Fumoleau P, Delgado FM, Delozier T et al. Phase II trial of weekly intravenous vinorelbine in first-line advanced breast cancer chemotherapy. J Clin Oncol. 1993; 11:1245-52. https://pubmed.ncbi.nlm.nih.gov/8315421

25. Romero A, Rabinovich MG, Vallejo CT et al. Vinorelbine as first-line chemotherapy for metastatic breast carcinoma. J Clin Oncol. 1994; 12:336-41. https://pubmed.ncbi.nlm.nih.gov/8113840

26. Smith GA. Current status of vinorelbine for breast cancer. Oncology. 1995; 9:767-79. https://pubmed.ncbi.nlm.nih.gov/7577376

27. Bruno S, Lira-Puerto V, Texeira L et al. Phase II trial with vinorelbine (Navelbine, NVB) in the treatment of advanced breast cancer (ABC). Ann Oncol. 1992; 3(Suppl 1):A268.

28. Garcia-Conde J, Lluch A, Martin A et al. Phase II trial of weekly IV vinorelbine in first-line advanced breast cancer chemotherapy. Ann Oncol. 1994; 5:854-7. https://pubmed.ncbi.nlm.nih.gov/7848890

29. Henderson IC. Chemotherapy for metastatic disease. In: Harris JR, Hellman S, Henderson IC et al, eds. Breast diseases. J. B. Lippincott: Philadelphia; 1991:604-65.

30. Twelves CJ, Dobbs NA, Curnow A et al. A phase II, multicentre, UK study of vinorelbine in advanced breast cancer. Br J Cancer. 1994; 70:990-3. https://pubmed.ncbi.nlm.nih.gov/7947109 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2033534/

31. Gasparini G, Caffo O, Barni S et al. Vinorelbine is an active antiproliferative agent in pretreated advanced breast cancer patients: a phase II study. J Clin Oncol. 1994; 12:2094-101. https://pubmed.ncbi.nlm.nih.gov/7931479

32. Degardin M, Bonneterre J, Hecquet B et al. Vinorelbine (Navelbine) as a salvage treatment for advanced breast cancer. Ann Oncol. 1994; 5:423-6. https://pubmed.ncbi.nlm.nih.gov/8075049

33. Jones S, Winer E, Vogel C et al. A randomized comparison of vinorelbine and melphalan in anthracycline-refractory advanced breast cancer. J Clin Oncol. 1995; 13:2567-74. https://pubmed.ncbi.nlm.nih.gov/7595708

34. Tresca P, Fumoleau P, Roche M et al. Vinorelbine, a new active drug in breast carcinoma: results of an ARTAC phase II trial. Breast Cancer Res Treat. 1990; 16:A66.

35. Barni S, Ardizzoia A, Bernardo G et al. Vinorelbine as single agent in pretreated patients with advanced breast cancer. Tumori. 1994; 80:280-2. https://pubmed.ncbi.nlm.nih.gov/7974798

36. Coppola F, Balbiani L, Blajman C et al. Vinorelbine (VNB) containing regimens in three different schedules for the treatment of advanced breast cancer (ABC). Proc Annu Meet Am Soc Clin Oncol. 1994; 13:A144.

37. Hochster H, Vogel C, Blumenreich M et al. A multicenter phase II study of navelbine (NVB) and doxorubicin (DOX) as first line chemotherapy of metastatic breast cancer. Proc Annu Meet Am Soc Clin Oncol. 1994; 13:A203.

38. Spielmann M, Dorval T, Turpin F et al. Phase II trial of vinorelbine/doxorubicin as first-line therapy of advanced breast cancer. J Clin Oncol. 1994; 12:1764-70. https://pubmed.ncbi.nlm.nih.gov/8083698

39. Gindrey-Vie B, Genot J-Y, Switsers O et al. Combination chemotherapy with Navelbine, epirubicin, and mitomycin C: a pilot study in advanced breast cancer (ABC). Eur J Cancer. 1991; 27(Suppl 2):A336.

40. Dieras V, Pierga J-Y, Extra J- M et al. Results of a combination of navelbine (NVB) and fluoro-uracil (FU) in advanced breast cancer (ABC) with a group sequential design (GSD). Ann Oncol. 1992; 3(Suppl 5):A178.

41. Ferrero JM, Wendling JL, Hoch M et al. Mitoxantrone (MTZ)-vinorelbine (VNR) as first line chemotherapy (CT) in metastatic breast cancer (MBC): a pilot study. Proc Annu Meet Am Soc Clin Oncol. 1993; 12:A234.

42. Baljman C, Balbiani L, Block J et al. Navelbine (N) plus adriamycin (A) vs FAC in advanced breast cancer. Proc Annu Meet Am Soc Clin Oncol. 1993; 12:A170.

43. Chadjaa M, Izzo J, May-Levin F et al. Preliminary data on 4’epiadriamycine (EPI)-vinorelbine (VNB): a new active combination in advanced breast cancer (ABC). Proc Annu Meet Am Soc Clin Oncol. 1993; 12:A152.

44. Toussaint C, Izzo J, Merle S et al. Phase I/II trial of continuous infusion vinorelbine for advanced breast cancer. J Clin Oncol. 1994; 12:2102-12. https://pubmed.ncbi.nlm.nih.gov/7931480

45. Botto HG, Galmarini F, Galvez C et al. Mitoxantrone (M), Ifosfamide (I), Vinorelbine (V), (MIV) and GM-CSF in refractory metastatic breast cancer (RMBC). Proc Annu Meet Am Soc Clin Oncol. 1994; 13:A143.

46. Agostara B, Gebbia V, Testa A et al. Mitomycin C and vinorelbine as second line chemotherapy for metastatic breast cancer. Tumori. 1994; 80:33-6. https://pubmed.ncbi.nlm.nih.gov/8191595

47. Galvez CA, Botto HG, Botto I et al. Chemotherapy with mitoxantrone, ifosfamide, and navelbine (MIN) as third line chemotherapy in advanced breast cancer (Meeting abstract). Ann Oncol. 1992; 3(Suppl 5):84.

48. Scheithauer W, Kornek G, Haider K et al. Effective second line chemotherapy of advanced breast cancer with navelbine and mitomycin C. Breast Cancer Res Treat. 1993; 26:49-53. https://pubmed.ncbi.nlm.nih.gov/8400323

49. Abeloff M. Vinorelbine (Navelbine) in the treatment of breast cancer: a summary. Semin Oncol. 1995; 22(Suppl 5):1-4. https://pubmed.ncbi.nlm.nih.gov/7740330

50. Vogel CL. Combination chemotherapy with vinorelbine (Navelbine) and mitoxantrone for metastatic breast cancer: a review. Semin Oncol. 1995; 22(Suppl 5):61-5. https://pubmed.ncbi.nlm.nih.gov/7740335

51. Fumoleau P, Delozier T, Extra JM et al. Vinorelbine (Navelbine) in the treatment of breast cancer: the European experience. Semin Oncol. 1995; 22(Suppl 5):22-9. https://pubmed.ncbi.nlm.nih.gov/7740332

52. Hortobagyi GN. Future directions for vinorelbine (Navelbine). Semin Oncol. 1995; 22(Suppl 5):80-7. https://pubmed.ncbi.nlm.nih.gov/7740338

53. Hayes DF, Henderson IC, Shapiro CL. Treatment of metastatic breast cancer: present and future prospects. Semin Oncol. 1995; 22(Suppl 5):5-21. https://pubmed.ncbi.nlm.nih.gov/7537913

54. Winer EP, Chu L, Spicer DV et al. Oral vinorelbine (Navelbine) in the treatment of advanced breast cancer. Semin Oncol. 1995; 22(Suppl 5):72-9. https://pubmed.ncbi.nlm.nih.gov/7740337

55. Winer E, O’Rourke M, Vogel C et al. A US multicenter phase II trial of oral Navelbine in elderly women with advanced breast cancer. Breast Cancer Res Treat. 1993; 27:A 24.

56. Spicer D, McCaskill-Stevens W, Oken M et al. Oral Navelbine (Navelbine) in women with previously treated advanced breast cancer (ABC): a phase II trial. Proc Annu Meet Am Soc Clin Oncol. 1994; 13:A105.

57. Queiber W, Doss A, Wander HE et al. Phase II study of vinorelbine by oral route (in a hard gelatin capsule) for metastatic breast cancer. Onkologie. 1991; 14:35-9. https://pubmed.ncbi.nlm.nih.gov/1647510

58. Hochster HS. Combined doxorubicin/vinorelbine (Navelbine) therapy in the treatment of advanced breast cancer. Semin Oncol. 1995; 22(Suppl 5):55-60. https://pubmed.ncbi.nlm.nih.gov/7740334

59. Feuvret L, Antoine E, Vuillemin E et al. Mitoxantrone, 5-fluorouracil, and vinorelbine in highly refractory advanced breast cancer. Proc IV Int Congress Anticancer Chemother. 1993; A57. Abstract.

60. Kayitalire K, Spielmann M, Brain E et al. Salvage chemotherapy (CT) with combination of mitoxantrone (MTZ) and vinorelbine (VRB) in resistant to anthracyclines advanced breast cancer (ABC). Proc Annu Meet Am Soc Clin Oncol. 1993; 12:A161.

61. Livingston RB, Ellis GK, Williams MA. Weekly vinorelbine (Navelbine, NVB) + GCSF in taxol-refractory metastatic breast cancer. Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A138.

62. Chang AY, Garrow GC. Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast and lung cancer. Semin Oncol. 1995; 22(Suppl 5):66-71. https://pubmed.ncbi.nlm.nih.gov/7740336

63. Kardinal CG, Cole JT, Gralla RJ et al. Navelbine (vinorelbine) and mitomycin c: combination therapy in advanced breast cancer. Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A225.

64. Koriech OM, Mughal TI. Phase II study of vinorelbine and mitomycin-c in advanced breast cancer. Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A251.

65. Nistico C, Ranuzzi M, Pace A et al. Weekly vinorelbine in previously treated patients with advanced breast cancer: preliminary results. Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A181.

66. Terzoli F, Ranuzzi M, Pace A et al. Weekly epirubicin plus vinorelbine in advanced breast cancer: preliminary results. Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A180.

67. Leone B, Vallejo C, Romero A et al. Ifosphamide (IFX) and vinorelbine (VNB) as first-line chemotherapy (FLC) for metastatic breast cancer (MBC). Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A187.

68. Wendling JL, Nouyrigat P, Vallicioni D et al. Cisplatinium (CDDP) - mitoxantrone (MTZ) - vinorelbine (VNR) as first line chemotherapy (CT) for metastatic breast cancer (MBC): a pilot study. Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A266.

69. Mustacchi G, Milani S, Sandri P et al. Cisplatin (CP) - vinorelbine (VNB): a new active combination in metastatic breast cancer. Breast Cancer Treat Res. 1994; 32:A30.

70. Bertsch LA, Donaldson G. Quality of life analyses from vinorelbine (Navelbine) clinical trials with metastatic breast cancer. Semin Oncol. 1995; 22(Suppl 5): 45-54. https://pubmed.ncbi.nlm.nih.gov/7740333

71. Canobbio L, Boccardo F, Pastorino G et al. Phase-II study of navelbine in advanced breast cancer. Semin Oncol. 1989; 16(Suppl 4):33-6. https://pubmed.ncbi.nlm.nih.gov/2711204

72. Ray-Coquand I, Blay JY, Bachelot T et al. Continuous i.v. infusion of vinorelbine (VNB) and bolus cisplatinum (CDDP) (civic regimen) an efficient regimen in hormone resistant breast cancers (MBC), after failure of anthracycline and/or paclitaxel. Proc Annu Meet Am Soc Clin Oncol. 1995; 14:A248.

73. Glaxo Wellcome, Research Triangle Park, NC: Personal communication.

74. Food and Drug Administration. Navelbine (vinorelbine tartrate) injection [August 29, 1997: Glaxo Wellcome]. MedWatch drug labeling changes. Rockville, MD; August 1997. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/default.htm

75. Sorio R, Robieux I, Galligioni E et al. Pharmacokinetics and tolerance of vinorelbine in elderly patients with metastatic breast cancer. Eur J Cancer. 1997; 33:301-3. https://pubmed.ncbi.nlm.nih.gov/9135505

76. Hoff PM, Valero V, Ibrahim N et al. Hand-foot syndrome following prolonged infusion of high doses of vinorelbine. Cancer. 1998; 82:965-9. https://pubmed.ncbi.nlm.nih.gov/9486588

77. Tester W, Forbes W, Leighton J. Vinorelbine-induced pancreatitis: a case report. J Natl Cancer Inst. 1997; 89:1631. https://pubmed.ncbi.nlm.nih.gov/9362167

78. Liebmann J, Friedman K. Adynamic ileus in a patient with non-small-cell lung cancer after treatment with vinorelbine. Am J Med. 1996; 101:658-9. https://pubmed.ncbi.nlm.nih.gov/9003116

79. Budman DR, Weiselberg L, O’Mara V. Severe neurotoxicity in vinorelbine-paclitaxel combinations. J Natl Cancer Inst. 1997; 89:87-8. https://pubmed.ncbi.nlm.nih.gov/8978412

80. Crawford J, O’Rourke M, Schiller JH et al. Randomized trial of vinorelbine compared with fluorouracil plus leucovorin in patients with stage IV non-small-cell lung cancer. J Clin Oncol. 1996; 14:2774-84. https://pubmed.ncbi.nlm.nih.gov/8874339

81. Bergeron A, Raffy O, Vannetzel JM. Myocardial ischemia and infarction associated with vinorelbine. J Clin Oncol. 1995; 13:531-2. https://pubmed.ncbi.nlm.nih.gov/7844615

82. Raderer M, Kornek G, Scheithauer W. Re: vinorelbine-induced pancreatitis: a case report. J Natl Cancer Inst. 1998; 90:329. https://pubmed.ncbi.nlm.nih.gov/9486821

83. Tassinari D, Sartori S, Gianni L et al. Is acute dyspnoea a rare side effect of vinorelbine? Ann Oncol\otf. 1997; 8:503-4. Letter.otf. 1997; 8:503-4. Letter.

84. Cuvier C, Espie M, Extra JM et al. Vinorelbine in pregnancy. Eur J Cancer. 1997; 33:169-70. https://pubmed.ncbi.nlm.nih.gov/9071922

85. Gridelli C, Perrone F, Gallo C et al. Vinorelbine is well tolerated and active in the treatment of elderly patients with advanced non-small cell lung cancer. A two-stage phase II study. Eur J Cancer. 1997; 33:392-7. https://pubmed.ncbi.nlm.nih.gov/9155522

86. Pace A, Bove L, Nistico C et al. Vinorelbine neurotoxicity: clinical and neurophysiological findings in 23 patients. J Neurol Neurosurg Psychiatry. 1996; 61:409-11. https://pubmed.ncbi.nlm.nih.gov/8890782 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC486585/

87. Vincent L, Lamrini R, Pommier P et al. Cardiac arrest and vinorelbine? Apropos of a case and review of the literature. Rev Pneumol Clin. 1997; 53:360-1. https://pubmed.ncbi.nlm.nih.gov/9616834

88. Estevez MD, Vieytes MR, Louzao MC et al. The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells. Inflamm Res. 1997; 46:119-24. https://pubmed.ncbi.nlm.nih.gov/9137989

89. Food and Drug Administration. Labeling and prescription drug advertising; content and format for labeling for human prescription drugs. 21 CFR Parts 201 and 202. Final Rule. [Docket No. 75N-0066] Fed Regist. 1979; 44:37434-67.

90. Department of Health and Human Services, Food and Drug Administration. Subpart B—Labeling requirements for prescription drugs and/or insulin. 21 CFR Ch. 1 (4-1-87 Ed.). 1987:18-24.

91. Non-small cell lung cancer. From: PDQ. Physician data query (database). Bethesda, MD: National Cancer Institute; 2004 Jun 22.

92. Wozniak AJ, Crowley JJ, Balcerzak SP et al. Randomized trial comparing cisplatin with cisplatin plus vinorelbine in the treatment of advanced non-small-cell lung cancer: a Southwest Oncology Group study. J Clin Oncol. 1998; 16:2459-65. https://pubmed.ncbi.nlm.nih.gov/9667264

93. Faulding. Vincristine sulfate injection prescribing information. Paramus, NJ; 2002 Sep.

94. Dyke RW. Treatment of inadvertent intrathecal injection of vincristine. N Engl J Med. 1989; 321:1270-1. https://pubmed.ncbi.nlm.nih.gov/2797094

95. Rittenberg CN, Gralla RJ, Rehmeyer TA. Assessing and managing venous irritation associated with vinorelbine tartrate. Oncol Nurs Forum. 1995; 22:707-10. https://pubmed.ncbi.nlm.nih.gov/7675673

96. Ginopoulos P, Mastronikolis NS, Karana A et al. Use of dexamethasone in the management of phlebitis caused by intravenous administration of vinorelbine. Med Sci Res. 1998; 26:397-8.

97. Morris M, Brader KR, Levenback C et al. Phase II study of vinorelbine in advanced and recurrent squamous cell carcinoma of the cervix. J Clin Oncol. 1998; 16:1094-8. https://pubmed.ncbi.nlm.nih.gov/9508195

98. Pignata S, Silvestro G, Ferrari E et al. Phase II study of cisplatin and vinorelbine as first-line chemotherapy in patients with carcinoma of the uterine cervix. J Clin Oncol. 1999; 17:756-60. https://pubmed.ncbi.nlm.nih.gov/10071263

99. Pfister DG, Johnson DH, Azzoli CG et al. American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol. 2004; 22:330-53. https://pubmed.ncbi.nlm.nih.gov/14691125

100. Kelly K, Crowley J, Bunn PA Jr et al. Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non–small-cell lung cancer: a Southwest Oncology Group trial. J Clin Oncol. 2001; 19:3210-8. https://pubmed.ncbi.nlm.nih.gov/11432888

101. Food and Drug Administration. MedWatch—Safety-related drug labeling changes: Oncovin (vincristine) [August 26, 1999]. From FDA web site. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/default.htm

102. Food and Drug Administration. MedWatch—Safety-related drug labeling changes: Vfend (voriconazole) [Dec 2003]. From FDA web site. http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/021466lbl.pdf

103. Food and Drug Administration. MedWatch—Safety-related drug labeling changes: Emend (aprepitant) [May 2003]. From FDA web site. http://www.accessdata.fda.gov/drugsatfda_docs/label/2003/21549_Emend_lbl.pdf

104. Burstein HJ, Harris LN, Marcom PK et al. Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm. J Clin Oncol. 2003; 21:2889-95. https://pubmed.ncbi.nlm.nih.gov/12885806

105. Burstein HJ, Kuter I, Campos SM et al. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2001; 19:2722-30. https://pubmed.ncbi.nlm.nih.gov/11352965

106. Breast cancer. From: PDQ. Physician data query (database). Bethesda, MD: National Cancer Institute; 2004 May 19.

107. Livingston RB, Ellis GK, Gralow JR et al. Dose-intensive vinorelbine with concurrent granulocyte colony-stimulating factor support in paclitaxel-refractory metastatic breast cancer. J Clin Oncol. 1997; 15:1395-400. https://pubmed.ncbi.nlm.nih.gov/9193331

108. Zelek L, Barthier S, Riofrio M et al. Weekly vinorelbine is an effective palliative regimen after failure with anthracyclines and taxanes in metastatic breast carcinoma. Cancer. 2001; 92:2267-72. https://pubmed.ncbi.nlm.nih.gov/11745280

109. Freyer G, Delozier T, Lichinister M et al. Phase II study of oral vinorelbine in first-line advanced breast cancer chemotherapy. J Clin Oncol. 2003; 21:35-40. https://pubmed.ncbi.nlm.nih.gov/12506167

110. Arriagada R, Bergman B, Dunant A et al. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med. 2004; 350:351-60. https://pubmed.ncbi.nlm.nih.gov/14736927

111. Blum RH. Adjuvant chemotherapy for lung cancer—a new standard of care. N Engl J Med. 2004; 350:404-5. https://pubmed.ncbi.nlm.nih.gov/14736933

112. Le Chevalier T, Brisgand D, Soria JC et al. Long term analysis of survival in the European randomized trial comparing vinorelbine/cisplatin to vindesine/cisplatin and vinorelbine alone in advanced non-small cell lung cancer. Oncologist. 2001; 6 Suppl 1:8-11. https://pubmed.ncbi.nlm.nih.gov/11181998

113. Anon. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. The Elderly Lung Cancer Vinorelbine Italian Study Group. J Natl Cancer Inst. 1999; 91:66-72. https://pubmed.ncbi.nlm.nih.gov/9890172

114. Langer CJ, Manola J, Bernardo P et al. Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J Natl Cancer Inst. 2002; 94:173-81. https://pubmed.ncbi.nlm.nih.gov/11830607

115. Gridelli C, Perrone F, Gallo C et al. Chemotherapy for elderly patients with advanced non-small-cell lung cancer: the Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst. 2003; 95:362-72. https://pubmed.ncbi.nlm.nih.gov/12618501

116. Bunn PA Jr, Lilenbaum R. Chemotherapy for elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst. 2003; 95:341-3. https://pubmed.ncbi.nlm.nih.gov/12618492

117. Scagliotti GV, De Marinis F, Rinaldi M et al. Phase III randomized trial comparing three platinum-based doublets in advanced non-small-cell lung cancer. J Clin Oncol. 2002; 20:4285-91. https://pubmed.ncbi.nlm.nih.gov/12409326

118. Gridelli C, Ardizzoni A, Le Chevalier T et al. Treatment of advanced non-small-cell lung cancer patients with ECOG performance status 2: results of an European Experts Panel. Ann Oncol. 2004; 15:419-26. https://pubmed.ncbi.nlm.nih.gov/14998843

119. Olithselvan A, Gorard DA. Vinorelbine and ischaemic colitis. Clin Oncol (R Coll Radiol). 2003; 15:166-7. https://pubmed.ncbi.nlm.nih.gov/12801059

120. Kagohashi K, Funayama Y, Satoh H et al. Fatal hepatic failure due to gemcitabine and vinorelbine. Ann Oncol. 2003; 14:960. https://pubmed.ncbi.nlm.nih.gov/12796036

121. Bosque E. Possible drug interaction between itraconazole and vinorelbine tartrate leading to death after one dose of chemotherapy. Ann Intern Med. 2001; 134:427. https://pubmed.ncbi.nlm.nih.gov/11242511

122. Domenech GH, Vogel CL. A review of vinorelbine in the treatment of breast cancer. Clin Breast Cancer. 2001; 2:113-28. https://pubmed.ncbi.nlm.nih.gov/11899783

123. Ferrazzi E, Toso S, Zanotti M et al. Typhlitis (neutropenic enterocolitis) after a single dose of vinorelbine. Cancer Chemother Pharmacol. 2001; 47:277-9. https://pubmed.ncbi.nlm.nih.gov/11320673

a. AHFS Drug Information 2007. McEvoy GK, ed. Vinorelbine tartrate. Bethesda, MD: American Society of Health-System Pharmacists; 2007:1231-7.

b. Mayne Pharma Inc.Vinorelbine tartrate injection, solution prescribing information. Paramus, NJ; 2004 Aug.

c. Pierre-Fabre Pharmaceuticals. Navelbine(vinorelbine tartrate) injection prescribing information. Parsippany, NJ; 2005 Aug..

d. Glaxo Smith Kline, Philadelphia, PA: Personal communication.

e. Pierre Fabre Medicament, Parsippany, NJ: Personal communication.

HID. Trissel LA. Handbook on injectable drugs. 14th ed. Bethesda, MD: American Society of Health-System Pharmacists; 2006:1634-41.

Medical Disclaimer