What is the difference between Polysporin and Neosporin?
Medically reviewed by Drugs.com. Last updated on April 8, 2025.
Neosporin contains neomycin which is not present in polysporin.
Polysporin is the brand name for a product containing bacitracin zinc and polymyxin B sulfate.
Neosporin is the brand name for a product containing bacitracin zinc, polymyxin B sulfate and neomycin sulfate.
They are both antibiotics used to treat infections and are available in several topical dosage forms ie eye drops, cream etc.
See: https://www.drugs.com/pro/neosporin.html
https://www.drugs.com/pro/polysporin.html
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