Does Tykerb have a good response?
The combination of Tykerb plus capecitabine (T+C) has a better response than capecitabine alone. Trials that investigated the endpoint “Time to Progression” (TTP) – defined as the time to tumor progression or death from breast cancer from enrollment in the trial, reported a significant difference for those women assigned T+C compared with those assigned capecitabine alone. The number of TTP events was 82 to 121 for women assigned T+C compared to 102 to 126 for those assigned capecitabine alone. Response rates ranged from 23.7% to 31.8% in those given T + C compared to 13.9 to 17.4% given capecitabine alone.
This result was significant enough to stop further enrolment in the trial after 4 months, unblind the trial, and transfer those women receiving capecitabine alone to treatment with Tykerb plus capecitabine. These women were then followed for another 2 years and with the median overall survival reported as 75 weeks in the Tykerb plus capecitabine group compared with 65.9 weeks in those women who originally only received capecitabine. After 2 years, 76% had died in the Tykerb plus capecitabine group compared with 82% in the capecitabine group alone.
Tykerb is recommended to be used in combination with:
- capecitabine for advanced or metastatic HER2 positive breast cancer who have already received prior therapy including an anthracycline, a taxane, and trastuzumab, but whose cancer has still progressed,
- letrozole for postmenopausal women with HER2-positive metastatic breast cancer for whom hormonal therapy is indicated.
References
- Tykerb (lapatinib) Updated 03/2023 Novartis Pharmaceuticals Corporation https://www.drugs.com/pro/tykerb.html
Read next
How does Tykerb work?
Tykerb (lapatinib) is a dual tyrosine kinase inhibitor and works by blocking both Epidermal Growth Factor Receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2). This helps stop or slow the spread of breast cancer cells. Continue reading
How long can you take Tykerb?
You can take Tykerb for as long as it keeps on preventing your cancer from growing and you are still tolerating it and not having unacceptable side effects. Your doctor will help you make this decision based on what you tell them and what they are seeing clinically, taking into account laboratory tests and investigations. Continue reading
What is the strongest chemotherapy drug for breast cancer?
Doxorubicin is considered one of the strongest chemotherapy drugs for breast cancer ever invented. It can kill cancer cells at every point in their life cycle, and it's used to treat a wide variety of cancers, not just breast cancer. Doxorubicin is also known as “The Red Devil” because it is a clear bright red color. It can cause your urine or other body fluids to turn a reddish color for 1 to 2 days after a dose is given, which is normal and temporary. Continue reading
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