Key Takeways

Biktarvy (bictegravir, emtricitabine and tenofovir alafenamide) is associated with multiple drug interactions as it contains three different medicines, increasing your risk. You should not take Biktarvy with dofetilide (Tikosyn), a drug used for heart rhythm disorders or rifampin (Rifadin), a medicine for tuberculosis (TB). These drugs are contraindicated with the use of Biktarvy (see Table 1).

Drug interactions may lead to increased side effects or lower the effectiveness of Biktarvy. In some cases, your doctor may need to adjust drug dosages.

Adverse drug interactions in general can occur due to certain drug-drug or drug-food combinations or due to some health conditions.

Biktarvy (bictegravir, emtricitabine and tenofovir alafenamide) is an oral, 3-drug combination tablet used to treat immunodeficiency virus type 1 (HIV-1). It's a complete regimen and its use with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.

Biktarvy can also cause problems if you have certain medical conditions. For example, liver disease such as hepatitis, kidney disease, and certain bone diseases like osteoporosis may be affected by Biktarvy.

Lower levels of Biktarvy in the blood have been observed in pregnancy, so your doctor will closely follow your viral loads., if needed.

It is important to have your doctor or pharmacist review your medications for possible drug interactions each time you start or even stop a medicine, over-the-counter (OTC) drug, vitamin, or herbal or dietary supplement.

What are drug interactions?

Anytime you take a medication and mix it with other medications, or certain foods, beverages, over-the-counter (OTC) medications, or herbal supplements you are at risk of a drug interaction.

Most drug interactions are not serious; however, a few are so it’s important to understand the possible outcome before you combine medications with other drugs, alcohol, certain foods or other substances.

The more medications you take, the greater the chance for your drug interacting with another medicine or substance. Drug-drug interactions can decrease how well your medications work, may increase minor or serious unexpected side effects, or even increase the blood level and toxicity of a certain drug.

Many drug interactions, including those with Biktarvy, occur if one drug affects another drug’s absorption through the stomach or intestine, distribution throughout the body, metabolism (break down) in the liver, or excretion through the kidneys.

Drug interactions can be complicated, especially if you take several medications, so always consult with your health care professional.

Drug Interactions with Biktarvy

Drug interactions with Biktarvy can lead to several outcomes, including:

• Loss of the intended therapeutic effect
• Increased risk of serious side effects from elevated blood levels of drugs
• Need to adjust the dose or dosing interval of Biktarvy or use alternative medications

Note: There are many other possible drug interactions with Biktarvy. Have your doctor or pharmacist screen for drug interactions each time you start - or even stop - a medication. Discuss these selected drug interactions with your health care providers.

Table 1: Selected Biktarvy Drug Interactions

Certain enzymes and transporters found in your body, often in your kidney, liver, or small intestine, can affect your drug therapy. Your pharmacist or doctor can check to see if you take any drugs that affect these compounds that may alter your response to Biktarvy or other medicines. These include:

• Organic cation transporter 2 (OCT2)
• Multidrug and toxin extrusion transporter 1 (MATE1)
• Cytochrome P450 3A (CYP3A)
• UDP-glucuronosyltransferase 1A1 (UGT1A1)
• P-glycoprotein (P-gp)
• Breast cancer resistance protein (BCRP)

Because emtricitabine and tenofovir, two components of Biktarvy, are primarily excreted by your kidneys, use of Biktarvy with drugs that affect kidney function may increase concentrations of emtricitabine, tenofovir, and other drugs that are metabolized or excreted through the kidney. This may increase the risk of side effects.

• Examples of drugs that may affect Biktarvy in this manner are: acyclovir, cidofovir, ganciclovir, valacyclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen or naproxen.

Because Biktarvy is a complete regimen, coadministration with other antiretroviral medications for the treatment of HIV-1 infection is not recommended. Possible drug interactions with other HIV medications are not known.

The manufacturer of Biktarvy notes that NO clinically significant drug interactions have been observed when Biktarvy is combined with:

• Ethinyl estradiol
• Ledipasvir/sofosbuvir
• Midazolam
• Norgestimate
• Sertraline
• Sofosbuvir
• Sofosbuvir/velpatasvir
• Sofosbuvir/velpatasvir/voxilaprevir

You can review these, and other potential Biktarvy drug interactions in the Drugs.com Drug Interaction Checker. Discuss any potential drug interaction with your healthcare provider before you start treatment.

Related questions

• Can Biktarvy be used for PrEP or PEP?
• What if I miss a dose of Biktarvy?
• Who are the actors in the Biktarvy commercials?

What health conditions are a concern if I take Biktarvy?

Drug interactions don’t always occur with just other drugs or foods. Your existing medical conditions can impact Biktavry, too.

For example, if you have ongoing liver, kidney or bone disease you may be at greater risk of worsening these conditions when you take Biktarvy. Tell your doctor if any of these conditions affect you.

There are several disease interactions with Biktarvy which include:

• liver (hepatic) diseases, including hepatitis B virus (HBV)
• kidney (renal) impairment
• hemodialysis
• bone toxicity such as osteoporosis

Other serious side effects for Biktarvy, which might affect these conditions, include:

• immune system changes
• kidney problems, including kidney failure
• liver problems, which may rarely lead to death (rare)
• too much lactic acid in your blood known as lactic acidosis (rare)

Kidney / Liver disease

Biktarvy is not recommended in patients with severe renal (kidney) impairment (estimated CrCl 15 to <30 mL/min), end-stage renal disease (estimated CrCl <15 mL/min) without chronic hemodialysis, severe hepatic (liver) impairment (Child-Pugh Class C), or no antiretroviral treatment history and ESRD who are receiving chronic hemodialysis. Your doctor can determine if you have kidney or liver impairment with lab tests.

Tell your doctor immediately if any new or worsening side effects occur. Too much lactic acid is a serious but rare medical emergency that can lead to death.Tell your doctor right away if you get any of these symptoms, which may be a signal of lactic acidosis:

• weakness or being more tired than usual
• unexpected muscle pain
• shortness of breath, fast breathing
• stomach pain with nausea and vomiting
• cold or blue hands and feet
• feeling dizzy or lightheaded
• fast or abnormal heartbeat

Hepatitis B (HBV) infection and liver toxicity

Biktarvy may worsen hepatitis B (HBV) infection. If you have both HIV-1 and HBV and stop taking Biktarvy, your HBV may suddenly become worse. Do not stop taking Biktarvy without first talking to your health care provider, as they will need to monitor your health. Your healthcare provider will test you for HBV infection before or when you start treatment.

Tell your doctor right away if you get any of these symptoms, which may be a signal of liver toxicity:

• skin or the white part of your eyes turns yellow
• dark “tea-colored” urine
• light-colored stools
• loss of appetite for several days or longer, nausea
• pain in your stomach area

Immune Reconstitution Syndrome

Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking treatment for HIV. Your immune system may get stronger and begin to fight infections that have been hidden in your body
for a long time. Tell your healthcare provider right away if you start having any new symptoms after starting your
HIV-1 medicine.

Symptoms can vary but may include:

• Fever
• Swollen lymph nodes
• Fatigue
• Worsening of pre-existing infection symptoms, like cough, shortness of breath or chest pain
• Eye problems
• Headaches
• Skin lesions

How is Biktarvy used?

Biktarvy, from Gilead, is an oral, 3-drug combination tablet used to treat immunodeficiency virus type 1 (HIV-1). It contains the integrase strand transfer inhibitor (INSTI) bictegravir, along with the nucleoside analog reverse transcriptase inhibitors (NRTIs) emtricitabine (FTC) and tenofovir alafenamide (TAF).

Uses

Biktarvy is FDA-approved as a complete regimen for the treatment of HIV-1 infection in adults and children weighing at least 14 kg (31 lbs):

• who have no antiretroviral treatment history or,
• to replace the current antiretroviral regimen in certain patients whose HIV virus is suppressed (HIV-1 RNA less than 50 copies per mL), and are on a stable antiretroviral regimen with no known resistance to bictegravir or tenofovir.

Biktarvy is recommended as a preferred single treatment regimen for initial and maintenance therapy in HIV-1 infection in current HIV treatment guidelines.

How it's taken

Biktarvy is taken once a day by mouth with or without food. It is taken by itself (not with other HIV-1 medicines) to treat HIV-1 infection because it is a complete regimen in one pill. Do not miss any doses.

Common side effects

The most common side effects you might experience with Biktarvy include:

• diarrhea (occurring in 6% of patients or 6 out of every 100 patients)
• nausea (occurring in 6% of patients)
• headache (occurring in 5% of patients)

Bottom Line

Biktarvy contains three different medications used to treat HIV-1, so this can greatly increase your risk for a drug interaction (see Table 1 above).

Not all drug interactions are serious, but some may be, so it is important to have a review of drug interactions each time you start or stop a medication. There are hundreds of possible drug interactions with Biktarvy, and not all Biktarvy drug interactions are listed in this review.

Always have your doctor or pharmacist review for possible drug interactions each time you start or stop a medication. Discuss these selected drug interactions with your health care providers. Never stop a medication without talking to your doctor first.

References

• De Clercq E, Zhang Z, Huang J, et al. Biktarvy for the treatment of HIV infection: Progress and prospects. Biochem Pharmacol. 2023 Nov;217:115862. doi: 10.1016/j.bcp.2023.115862
• Deeks ED. Bictegravir/Emtricitabine/Tenofovir Alafenamide: A Review in HIV-1 Infection. Drugs. 2018 Nov;78(17):1817-1828. doi: 10.1007/s40265-018-1010-7. Erratum in: Drugs. 2019 Apr;79(6):687. doi: 10.1007/s40265-019-01101-4
• Biktarvy [package insert]. Foster City, CA. Gilead. 10/2024. Accessed July 19, 2025 at https://www.gilead.com/~/media/files/pdfs/medicines/hiv/biktarvy/biktarvy_pi.pdf
• Biktarvy. Important Facts. Gilead.com. 2/2024. Accessed Dec. July 19, 2025 at https://services.gileadhiv.com/content/pdf/BIKTARVY/Important_Facts.pdf

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Drug information

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• Side Effects of Biktarvy (detailed)
• Biktarvy user reviews (226)

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