Will I lose weight with Entyvio?
Weight loss is not reported as a side effect of Entyvio, but digestive tract diseases such as Crohn’s disease or ulcerative colitis can frequently lead to diarrhea, stomach cramps and a loss of appetite, which may cause unintentional weight loss.
Entyvio can also cause liver problems in some people. Liver problems might lead to a loss of appetite, which in turn could lead to weight loss. Tell your doctor right away if you experience any of the following symptoms:
- tiredness
- loss of appetite
- nausea
- pain on the right side of your stomach
- dark or "tea"-colored urine
- yellowing of the skin and eyes (jaundice).
You can read more about Entyvio side effects here.
Does Entyvio cause weight gain?
Weight gain is not a side effect with Entyvio, but some corticosteroid medicines used with Enytvio, like prednisone or budesonide, might cause fluid retention or weight gain. Corticosteroids are sometimes used to treat inflammatory symptoms of ulcerative colitis or Crohn's disease.
Due to the side effects, corticosteroids are not usually given long term.
In addition, when gastrointestinal diseases such as Crohn’s disease or ulcerative colitis begin to heal, patients who have previously lost weight may gain some weight back as their symptoms improve.
Learn more: Can I drink alcohol while taking Entyvio?
This is not all the information you need to know about Entyvio (vedolizumab) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.
Related questions
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References
- Takeda Pharmaceuticals, Inc. Entyvio (vedolizumab) prescribing information. Deerfield, IL; 4/2024. Accessed July 19, 2025 at https://content.takeda.com/?contenttype=PI&product=ENTY&language=ENG&country=USA&documentnumber=1
Read next
Can I drink alcohol while taking Entyvio?
Although there is no indication that alcohol and Entyvio (vedolizumab) have unsafe interactions, you should ask your doctor before drinking alcohol while taking Entyvio. Continue reading
Can I take antibiotics while on Entyvio?
The use of Entyvio (generic name: vedolizumab) is not recommended in patients with an active, severe infection until the infection is controlled. Your doctor may consider withholding your Entyvio treatment if you develop a severe infection while on treatment with Entyvio. Your doctor will be able to best decide if you need to take an antibiotic or stop Entyvio treatment. Do not stop taking Entyvio without speaking to your doctor. Continue reading
Does Entyvio increase the risk of cancer?
Entyvio (vedolizumab) does not seem to increase your risk of developing cancer. Research suggests that the number of people who develop cancer while taking Entyvio is similar to the number of people expected to develop cancer if they were not taking the drug. Continue reading
See also:
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Drug information
- Entyvio Information for Consumers
- Entyvio prescribing info & package insert (for Health Professionals)
- Side Effects of Entyvio (detailed)
- Entyvio user reviews (167)
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